 | | Vol. 14.26 – 15 July, 2020 |
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| Researchers identified corresponding transcriptional profiles in human glioblastoma and describe patient-derived xenografts with species-conserved subtype-discriminating functional properties.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found a conserved neural tri-lineage cancer hierarchy centered around glial progenitor-like cells. They also found that this progenitor population contains the majority of the cancer’s cycling cells, and, using RNA velocity, is often the originator of the other cell types.
[Nature Communications] |
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| Scientists found that advillin was overexpressed in all the glioblastomas they had tested including glioblastoma stem/initiating cells, but hardly detectable in non-neoplastic astrocytes, neural stem cells or normal brain.
[Nature Communications] |
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| Investigators showed that hyperpolarization-activated cyclic nucleotide-gated ion channels were dynamically expressed over the cell cycle in neural stem cells.
[Molecular Cancer Research] |
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| The authors examined the dose-dependent neurotoxicity of dextran-coated iron oxide nanoparticles on cultured primary neurons harvested from postnatal day 0-1 mouse brains.
[Scientific Reports] |
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| Primary human endothelial cells are exposed to controlled concentrations of polymer‐functionalized silica nanoparticles to induce lysosomal damage and achieve cytosolic delivery.
[Small] |
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| The authors characterized neural precursor cells and their daughters at different stages of neurogenesis in the spiralian annelid Capitella teleta.
[BMC Evolutionary Biology] |
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| Researchers demonstrated that the RNAs related to cell proliferation and astrocyte differentiation were upregulated in human mesenchymal stem cells when co-cultured with exosomes obtained from the culture medium of human glioma cells.
[PLoS One] |
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| Scientists evaluated the efficacy of a combination of temozolomide plus curcumin or nanomicellar-curcumin on the inhibition of glioblastoma growth in vitro, via effects on autophagy, apoptosis, and the Wnt signaling pathway.
[Journal of Molecular Neuroscience] |
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| The author describes how new CRISPR-based functional genomics approaches can uncover disease mechanisms and therapeutic targets in neurological diseases.
[Nature Reviews Neurology] |
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| Researchers review current knowledge of the organization and function of nodes of Ranvier in the CNS.
[Nature Reviews Neurology] |
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| Scientists discuss approaches for the rigorous designation of interneuron subgroups or subtypes in transplantation studies, and challenges to this field, including the protracted maturation of human interneurons.
[Stem Cells] |
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| Biogen and Eisai Co., Ltd. announced that Biogen has completed the submission of a biologics license application to the FDA for the approval of aducanumab, an investigational treatment for Alzheimer’s disease.
[Biogen, Inc.] |
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| US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.
[BBC] |
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| The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
[Nature News] |
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| August 17 – August 19
Virtual |
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| | Klinikum rechts der Isar of the Technische Universität München – Munich, Germany |
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| | BrightFocus Foundation – Clarksburg, Maryland, United States |
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| | Simon Fraser University – Burnaby, British Columbia, Canada |
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| | NIH National Institute of Mental Health – Bethesda, Maryland, United States |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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