Neural Cell News Volume 14.28 | July 29 2020

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    2020-07-22 | NCN 14.28


    Neural Cell News by STEMCELL Technologies
    Vol. 14.28 – 29 July, 2020
    TOP STORY

    Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

    The authors used a combination of imaging, single cell, and surgical approaches to identify a CD69+ CD4 T cell population in both the mouse and human brain, distinct from circulating CD4 T cells.
    [Cell]

    Full ArticleGraphical Abstract

    Click to learn more about the STEMdiff Cerebral Organoid Kit from STEMCELL Technologies
    PUBLICATIONSRanked by the impact factor of the journal

    Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex

    Investigators determined allelic expression in cortical cell types and established a quantitative platform to interrogate imprinting in single cells.
    [Neuron]

    Full ArticleGraphical Abstract

    Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

    Scientists describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction between the striatum and globus pallidus.
    [Neuron]

    AbstractGraphical Abstract

    Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon

    The authors describe a robust genetic program that intrinsically attenuated apoptosis competence in neurons.
    [Neuron]

    AbstractGraphical Abstract

    Zeta Inhibitory Peptide Attenuates Learning and Memory by Inducing NO-Mediated Downregulation of AMPA Receptor

    Scientists found that zeta inhibitory peptide induced redistribution of the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreased AMPAR-mediated currents in the nucleus accumbens.
    [Nature Communications]

    Full Article

    Developmental GABA Polarity Switch and Neuronal Plasticity in Bioengineered Neuronal Organoids

    Researchers report directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
    [Nature Communications]

    Full Article

    Mithramycin Selectively Attenuates DNA-Damage-Induced Neuronal Cell Death

    The authors suggested that Sp1 was required for p53-mediated transactivation of neuronal pro-apoptotic molecules and that mithramycin might have attenuated neuronal cell death in conditions predominantly involving DNA-damage-induced p53-dependent intrinsic apoptosis.
    [Cell Death & Disease]

    Full Article

    Gene Expression Profiling of Glioblastoma Cell Lines Depending on TP53 Status after Tumor-Treating Fields (TTFields) Treatment

    Researchers identified the key gene signatures and pathways associated with TTFields in four glioblastoma cell lines varying in TP53 mutation status using gene profiling and functional annotation.
    [Scientific Reports]

    Full Article

    Sovateltide (IRL-1620) Activates Neuronal Differentiation and Prevents Mitochondrial Dysfunction in Adult Mammalian Brains Following Stroke

    Investigators showed a novel role of endothelin B receptors in neuronal progenitor cells and mitochondrial fate determination in cerebral ischemia, and in improving neurological deficit after stroke.
    [Scientific Reports]

    Full Article


    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    REVIEWS

    Brain Energy Rescue: An Emerging Therapeutic Concept for Neurodegenerative Disorders of Ageing

    Scientists discuss the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics.
    [Nature Reviews Drug Discovery]

    Abstract

    Remodeling without Destruction: Non-Proteolytic Ubiquitin Chains in Neural Function and Brain Disorders

    The authors discuss recent advances on nonconventional ubiquitin chains in neural development, function, plasticity, and related pathologies.
    [Molecular Psychiatry]

    Abstract

    INDUSTRY AND POLICY NEWS

    Axial Biotherapeutics Announces a Research Grant Award from The Michael J. Fox Foundation for the Development of an Enteric Nervous System Model to Assess Novel Parkinson’s Disease Therapeutics

    Axial Biotherapeutics announced it has received a research grant of $440,000 from The Michael J. Fox Foundation for Parkinson’s Research through its Therapeutic Pipeline Program. The award will enable development of a novel in vitro model system of the enteric nervous system derived from alpha-synuclein overexpressing mice to support the discovery of a small molecule for the treatment of Parkinson’s disease.
    [Axial Biotherapeutics]

    Press Release

    UCB Enters into Collaboration with Roche to Develop Antibody Treatment for People Living with Alzheimer’s Disease

    UCB announced an agreement to enter into a world-wide, exclusive license agreement with Roche and Genentech, a member of the Roche Group, for the global development and commercialization of UCB0107 in Alzheimer’s Disease.
    [UCB (PR Newswire Inc.)]

    Press Release

    French Science Bill Promises Boost to Public R&D

    The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
    [ScienceInsider]

    Editorial

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    Nanyang Technological University – Singapore, Singapore

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    Klinikum rechts der Isar of the Technische Universität München – Munich, Germany

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