| Vol. 14.28 – 29 July, 2020 |
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| The authors used a combination of imaging, single cell, and surgical approaches to identify a CD69+ CD4 T cell population in both the mouse and human brain, distinct from circulating CD4 T cells. [Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators determined allelic expression in cortical cell types and established a quantitative platform to interrogate imprinting in single cells. [Neuron] |
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| Scientists describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction between the striatum and globus pallidus. [Neuron] |
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| The authors describe a robust genetic program that intrinsically attenuated apoptosis competence in neurons. [Neuron] |
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| Scientists found that zeta inhibitory peptide induced redistribution of the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreased AMPAR-mediated currents in the nucleus accumbens. [Nature Communications] |
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| Researchers report directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format. [Nature Communications] |
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| The authors suggested that Sp1 was required for p53-mediated transactivation of neuronal pro-apoptotic molecules and that mithramycin might have attenuated neuronal cell death in conditions predominantly involving DNA-damage-induced p53-dependent intrinsic apoptosis. [Cell Death & Disease] |
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| Researchers identified the key gene signatures and pathways associated with TTFields in four glioblastoma cell lines varying in TP53 mutation status using gene profiling and functional annotation. [Scientific Reports] |
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| Investigators showed a novel role of endothelin B receptors in neuronal progenitor cells and mitochondrial fate determination in cerebral ischemia, and in improving neurological deficit after stroke. [Scientific Reports] |
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| Scientists discuss the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics. [Nature Reviews Drug Discovery] |
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| The authors discuss recent advances on nonconventional ubiquitin chains in neural development, function, plasticity, and related pathologies. [Molecular Psychiatry] |
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| Axial Biotherapeutics announced it has received a research grant of $440,000 from The Michael J. Fox Foundation for Parkinson’s Research through its Therapeutic Pipeline Program. The award will enable development of a novel in vitro model system of the enteric nervous system derived from alpha-synuclein overexpressing mice to support the discovery of a small molecule for the treatment of Parkinson’s disease. [Axial Biotherapeutics] |
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| UCB announced an agreement to enter into a world-wide, exclusive license agreement with Roche and Genentech, a member of the Roche Group, for the global development and commercialization of UCB0107 in Alzheimer’s Disease. [UCB (PR Newswire Inc.)] |
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| The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years. [ScienceInsider] |
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| October 20 – October 21 Virtual |
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| Nanyang Technological University – Singapore, Singapore |
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| Nanyang Technological University – Singapore, Singapore |
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| Nanyang Technological University – Singapore, Singapore |
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| BrightFocus Foundation – Clarksburg, Maryland, United States |
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| Klinikum rechts der Isar of the Technische Universität München – Munich, Germany |
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