Neural Cell News Volume 14.29 | Aug 05 2020

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    2020-08-05 | NCN 14.29


    Neural Cell News by STEMCELL Technologies
    Vol. 14.29 – 5 August, 2020
    TOP STORY

    A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

    Scientists showed that Notch signaling-deficient astrocytes could generate new neurons after injury. Using single-cell RNA sequencing, they found that, when Notch signaling was blocked, astrocytes transitioned to a neural stem cell-like state.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract


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    PUBLICATIONSRanked by the impact factor of the journal

    Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury

    The authors performed calcium imaging of neural stem/progenitor cell grafts in spinal cord injury sites in vivo and in adult spinal cord slices.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Purine Metabolism Regulates DNA Repair and Therapy Resistance in Glioblastoma

    By correlating intracellular metabolite levels with radiation resistance across dozens of genomically-distinct models of glioblastoma, researchers find that purine metabolites, especially guanylates, strongly correlate with radiation resistance.
    [Nature Communications]

    Full Article

    Modeling SHH-Driven Medulloblastoma with Patient iPS Cell-Derived Neural Stem Cells

    Investigators found that Gorlin neuroepithelial stem (NES) cells formed tumors in mouse cerebellum mimicking human medulloblastoma. Retransplantation of tumor-isolated NES cells resulted in accelerated tumor formation, cells with reduced growth factor dependency, enhanced neurosphere formation in vitro, and increased sensitivity to Vismodegib.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Activation of a Neural Stem Cell Transcriptional Program in Parenchymal Astrocytes

    Researchers used single-cell RNA sequencing to characterize neurogenesis by Notch-depleted striatal astrocytes in vivo.
    [eLife]

    Abstract

    ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma

    Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation.
    [Oncogene]

    Abstract

    Inhibition of miR-1193 Leads to Synthetic Lethality in Glioblastoma Multiforme Cells Deficient of DNA-PKcs

    By implementing a highly efficient high-throughput screening platform using an in-house-constructed genome-wide human microRNA inhibitor library, scientists demonstrated that miR-1193 inhibition sensitized glioblastoma multiforme tumor cells with DNA-PKcs deficiency.
    [Cell Death & Disease]

    Full Article

    Fabrication of Homotypic Neural Ribbons as a Multiplex Platform Optimized for Spinal Cord Delivery

    Neural ribbons offer multifunctionality in vitro including co-encapsulation of the injury site ESM modifier chondroitinase ABC, tested in glial scar models, and ability of cervically-patterned spinal cord neural stem cells to differentiate within neural ribbons and project axons for integration with 3D external matrices.
    [Scientific Reports]

    Full Article

    Pharmacologically Inhibiting Phosphoglycerate Kinase 1 for Glioma with NG52

    Researchers developed a high-throughput screening and discovered that NG52, previously known as a yeast cell cycle-regulating kinase inhibitor, could inhibit the kinase activity of phosphoglycerate kinase 1.
    [Acta Pharmacologica Sinica]

    Abstract

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    REVIEWS

    Diversity and Function of Corticopetal and Corticofugal GABAergic Projection Neurons

    Research conducted over the past 10 years has revealed that cortical GABAergic projection neurons were highly diverse in terms of molecular marker expression, synaptic targeting, activity pattern during distinct behavioral states and precise temporal recruitment relative to ongoing neuronal network oscillations.
    [Nature Reviews Neuroscience]

    Abstract

    Taming Human Brain Organoids One Cell at a Time

    The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
    [Seminars in Cell & Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    MODAG Successfully Completes Phase I Study of their Lead Candidate Anle138b and Receives Additional USD 1.4 Million from Michael J. Fox Foundation

    MODAG announced the successful completion of its first clinical trial of anle138b in healthy volunteers. Based on the positive Phase I study results, MODAG was also able to obtain additional funding of USD 1.4 million from The Michael J. Fox Foundation for Parkinson’s research.
    [MODAG]

    Press Release

    Quadriga BioSciences Initiates Clinical Trial of Innovative, Targeted Treatment for Brain Cancers

    Quadriga BioSciences announced that the first patient has been dosed in a Phase I study of QBS10072S in patients with advanced malignancies.
    [Quadriga BioSciences]

    Press Release

    FEATURED EVENT

    53rd Annual Meeting Society for Leukocyte Biology

    September 30 – October 3
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Biophysical Cell Analysis and Sorting Instrumentation

    Nanyang Technological University – Singapore, Singapore

    Director of Scientific Programs – Neuroscience

    BrightFocus Foundation – Clarksburg, Maryland, United States

    Project Officer – Spinal Cord Injury and Neural Tissue Engineering

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Researcher – Neurobiology and Neurodegeneration Research

    Klinikum rechts der Isar of the Technische Universität München – Munich, Germany

    Research Fellow – Neural Cell Therapy

    Nanyang Technological University – Singapore, Singapore

    > See All Jobs

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