Neural Cell News Volume 14.30 | Aug 12 2020

May 12, 2022

NCN 14.30 | Aug 12 2020

Neural Cell News by STEMCELL Technologies

Vol. 14.30 – 12 August, 2020

TOP STORY

Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture

Researchers used intersectional genetic strategy to ablate NPY⁺ noradrenergic neurons and/or adrenal chromaffin cells.
[Neuron]

Abstract Graphical Abstract

He knew neuronal cultures should be active. So he invented a new medium. Watch Cedric Bardy's webinar.

PUBLICATIONSRanked by the impact factor of the journal

EED-Mediated Histone Methylation Is Critical for CNS Myelination and Remyelination by Inhibiting WNT, BMP, and Senescence Pathways

Depletion of embryonic ectoderm development (EED), a core polycomb repressive complex 2 subunit, reduced differentiation of oligodendrocyte progenitors (OPCs), and caused an OPC-to-astrocyte fate switch in a region-specific manner.
[Science Advances]

Full Article

EGFR/FOXO3a/BIM Signaling Pathway Determines Chemosensitivity of BMP4-Differentiated Glioma Stem Cells to Temozolomide

Scientists examined whether epidermal growth factor receptor (EGFR) signaling affects bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]

Full Article

Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway

Investigators demonstrated that treatment with phorbol 12-myristate 13-acetate for six hours significantly increased acid-sensing ion channel 1a (ASIC1a) protein expression and ASIC currents in NS20Y cells, a neuronal cell line, and in primary cultured mouse cortical neurons.
[Molecular Neurobiology]

Abstract

Identification of Substances which Regulate Activity of Corticotropin-Releasing Factor-Producing Neurons in the Paraventricular Nucleus of the Hypothalamus

Researchers developed a screening method using calcium imaging to identify how physiological substances directly affect the activity of corticotropin-releasing factor-producing neurons in the paraventricular nucleus of the hypothalamus.
[Scientific Reports]

Full Article

Neurotrophic Factors and Target-Specific Retrograde Signaling Interactions Define the Specificity of Classical and Neuropeptide Cotransmitter Release at Identified Lymnaea Synapses

Scientists report that an identified Lymnaea neuron selectively released its classical small molecule and peptide neurotransmitters, acetylcholine and FMRFamide-derived neuropeptides, to differentially influence the activity of distinct postsynaptic targets that coordinated cardiorespiratory behaviour.
[Scientific Reports]

Full Article

Carnosine Suppresses Human Glioma Cells under Normoxic and Hypoxic Conditions Partly via Inhibiting Glutamine Metabolism

In this study, researchers investigated the effects of carnosine on human glioma U87 and U251 cell lines under normoxia and hypoxia.
[Acta Pharmacologica Sinica]

Abstract

α-Cyperone Inhibitory Effects on Tumor-Derived DNA Trigger Microglia by STING Pathway

Tumor-derived DNA isolated from Lewis cell lines was transfected into microglia, and analyzed for stimulator of interferon genes (STING) effects.
[Journal of Ethnopharmacology]

Abstract Graphical Abstract

Water-Extracted Ganoderma lucidum Induces Apoptosis and S-Phase Arrest via Cyclin-CDK2 Pathway in Glioblastoma Cells

The anti-tumor effect of a water extract of G. lucidum was investigated using brain tumor cells. Researchers used an analysis of cell viability, flow cytometry, the IncuCyte live-cell analysis system, and Western blotting to study its effects.
[Molecules]

Full Article

Antagonistic Effects of IL-17 and Astragaloside IV on Cortical Neurogenesis and Cognitive Behavior after Stroke in Adult Mice through Akt/GSK-3β Pathway

Researchers showed knocking out IL-17 contributed to regulating PI3K/Akt pathway, promoting neural stem cell proliferation, and neurogenesis after ischemic stroke.
[Cell Death Discovery]

Full Article

cc4a4e97-840c-4b83-8858-06f35d7acd9d_ON780CR-Celebration-of-science-Kristen

REVIEWS

Synergy between Amyloid-β and Tau in Alzheimer’s Disease

The authors highlight the latest evidence base pertaining to the complex Aβ–tau interaction and underscore its crucial importance to elucidating disease pathogenesis and the design of next-generation Alzheimer’s disease therapeutic trials.
[Nature Neuroscience]

Abstract

INDUSTRY AND POLICY NEWS

CurePSP Partners with Rainwater to Support Pioneering Neurodegeneration Research

CurePSP has awarded a $100,000 grant for a potentially breakthrough study that will employ 3D organoid models that have been shown to produce structures similar to those seen in the human brain to understand the effects of protein mutations that are associated with neurodegeneration.
[CurePSP]

Press Release

Neurogene Announces FDA Orphan Drug Designation for CLN7 Batten Disease Gene Therapy

FDA grants Orphan Drug Designation to Neurogene’s adeno-associated virus vector with engineered transgene encoding the human CLN7 gene.
[Neurogene, Inc.]

Press Release

FEATURED EVENT

Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture

EED-Mediated Histone Methylation Is Critical for CNS Myelination and Remyelination by Inhibiting WNT, BMP, and Senescence Pathways

EGFR/FOXO3a/BIM Signaling Pathway Determines Chemosensitivity of BMP4-Differentiated Glioma Stem Cells to Temozolomide

Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway

Identification of Substances which Regulate Activity of Corticotropin-Releasing Factor-Producing Neurons in the Paraventricular Nucleus of the Hypothalamus

Neurotrophic Factors and Target-Specific Retrograde Signaling Interactions Define the Specificity of Classical and Neuropeptide Cotransmitter Release at Identified Lymnaea Synapses

Carnosine Suppresses Human Glioma Cells under Normoxic and Hypoxic Conditions Partly via Inhibiting Glutamine Metabolism

α-Cyperone Inhibitory Effects on Tumor-Derived DNA Trigger Microglia by STING Pathway

Water-Extracted Ganoderma lucidum Induces Apoptosis and S-Phase Arrest via Cyclin-CDK2 Pathway in Glioblastoma Cells

Antagonistic Effects of IL-17 and Astragaloside IV on Cortical Neurogenesis and Cognitive Behavior after Stroke in Adult Mice through Akt/GSK-3β Pathway

Synergy between Amyloid-β and Tau in Alzheimer’s Disease

CurePSP Partners with Rainwater to Support Pioneering Neurodegeneration Research

Neurogene Announces FDA Orphan Drug Designation for CLN7 Batten Disease Gene Therapy

ISSCR: Advances in Stem Cell Research: From Single Cells to Organs

> See All Events

Research Fellow – Biophysical Cell Analysis and Sorting Instrumentation

Project Officer – Spinal Cord Injury and Neural Tissue Engineering

Postdoctoral Researcher – Neurobiology and Neurodegeneration Research

Postdoctoral Fellow – Biomaterial and Scaffold Design

Research Fellow – Neural Cell Therapy

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