Neural Cell News Volume 14.31 | 19 Aug 2020

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    NCN 14.31 | Aug 19 2020


    Neural Cell News by STEMCELL Technologies
    Vol. 14.31 – 19 August, 2020
    TOP STORY

    Mitochondrial Dynamics in Postmitotic Cells Regulate Neurogenesis

    Scientists revealed that shortly after cortical stem cells have divided, daughter cells destined to self-renew underwent mitochondrial fusion, whereas those that retained high levels of mitochondria fission became neurons.
    [Science]

    Abstract

    Her 'mini-brains' creation was unexpected. Her protocol was groundbreaking. Watch Madeline Lancaster's webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Importin α3 Regulates Chronic Pain Pathways in Peripheral Sensory Neurons

    Importin α3–bound c-Fos and importin α3–deficient neurons were impaired in c-Fos nuclear import. Knockdown or dominant-negative inhibition of c-Fos or c-Jun in sensory neurons reduced neuropathic pain.
    [Science]

    Abstract

    Integrated
    Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

    Integrated analysis in H3.3K27M cells, tumors, and in vivo imaging in patients showed enhanced glycolysis, glutaminolysis, and tricarboxylic acid cycle metabolism with high alpha-ketoglutarate production.
    [Cancer Cell]

    AbstractGraphical Abstract

    Transcriptional
    Reprograming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

    By profiling sensory ganglia at single-cell resolution, researchers found that all somatosensory neuronal subtypes underwent a similar transcriptional response to peripheral nerve injury that both promoted axonal regeneration and suppressed cell identity.
    [Neuron]

    Abstract

    Dscam1
    Establishes the Columnar Units through Lineage-Dependent Repulsion between Sister Neurons in the Fly Brain

    Researchers showed that neurons from the same lineage project to different columns under control of Down syndrome cell adhesion molecule in the fly brain.
    [Nature Communications]

    Full Article

    Ybx1 Fine-Tunes PRC2 Activities to Control Embryonic Brain Development

    Scientists found that Polycomb repressive complex 2 (PRC2) interacted with the nucleic acid–binding protein Ybx1. In neural progenitor cells, Ybx1 controlled self-renewal and neuronal differentiation.
    [Nature Communications]

    Full Article

    TRIM22
    Activates NF-κB Signaling in Glioblastoma by Accelerating the Degradation of IκBα

    Investigators screened a panel of tripartite motif (TRIM) family proteins and identified TRIM22 as a potential activator of NF-κB using an NF-κB driven luciferase reporter construct in glioblastoma cell lines.
    [Cell Death & Differentiation]

    Full Article

    Fractalkine-Dependent
    Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination

    Investigators showed a population of ameboid microglia migrating from the ventricular zone into the corpus callosum during early postnatal development, phagocytosing viable oligodendrocyte progenitor cells before onset of myelination.
    [Cell Reports]

    Full Article

    Flavagline
    Synthetic Derivative Induces Senescence in Glioblastoma Cancer Cells without Being Toxic to Healthy Astrocytes

    Investigators explored the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. They indicated that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions.
    [Scientific Reports]

    Full Article

    Tunneling
    Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment

    The authors showed that heterogeneous glioblastoma cells express TNTs upon oxidative stress and temozolomide/ionizing radiation treatment.
    [iScience]

    AbstractFull Article
    Graphical Abstract

    He knew neuronal cultures should be active. So he invented a new medium. Watch Cedric Bardy's webinar.
    REVIEWS

    Neuronal Regulation of Immunity: Why, How and Where?

    The authors evaluate the potential benefits to the immune system that arise by taking advantage of some of the brain’s unique features, such as its capacity to integrate and synchronize physiological functions, its predictive capacity and its speed of response.
    [Nature Reviews Immunology]

    Abstract

    The Role of Astrocytes in CNS Inflammation

    Scientists provide an overview of the role of astrocytes in CNS inflammation, highlighting recent discoveries on astrocyte subsets and the mechanisms that control them.
    [Trends in Immunology]

    Abstract

    Microglia
    and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

    The authors discuss how to bridge transcriptional states to specific functions so we can develop therapies to mediate negative effects of altered microglia–astrocyte interactions.
    [Trends in Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    FDA
    Approves Genentech’s Enspryng for Neuromyelitis Optica Spectrum Disorder

    The FDA approved Genentech’s EnspryngTM as the first and only subcutaneous treatment for adults living with anti-aquaporin-4 antibody positive neuromyelitis optica spectrum disorder.
    [Genentech]

    Press Release

    FEATURED EVENT

    From Stem Cells to Human Development

    September 8 – September 11
    Virtual


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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Brain Tumor Dormancy/Metastasis

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Research Fellow – Neural Cell Therapy

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Researcher – Neurobiology and Neurodegeneration Research

    Klinikum rechts der Isar of the Technische Universität München – Munich, Germany


    Postdoctoral Research Fellow – Molecular Neuroscience

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States


    Project Officer – Spinal Cord Injury and Neural Tissue Engineering

    Nanyang Technological University – Singapore, Singapore

    Research
    Fellow – Biophysical Cell Analysis and Sorting Instrumentation

    Nanyang Technological University – Singapore, Singapore

    > See All Jobs

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