| Vol. 14.31 – 19 August, 2020 |
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| Scientists revealed that shortly after cortical stem cells have divided, daughter cells destined to self-renew underwent mitochondrial fusion, whereas those that retained high levels of mitochondria fission became neurons. [Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Importin α3–bound c-Fos and importin α3–deficient neurons were impaired in c-Fos nuclear import. Knockdown or dominant-negative inhibition of c-Fos or c-Jun in sensory neurons reduced neuropathic pain. [Science] |
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| Integrated analysis in H3.3K27M cells, tumors, and in vivo imaging in patients showed enhanced glycolysis, glutaminolysis, and tricarboxylic acid cycle metabolism with high alpha-ketoglutarate production. [Cancer Cell] |
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| By profiling sensory ganglia at single-cell resolution, researchers found that all somatosensory neuronal subtypes underwent a similar transcriptional response to peripheral nerve injury that both promoted axonal regeneration and suppressed cell identity. [Neuron] |
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| Researchers showed that neurons from the same lineage project to different columns under control of Down syndrome cell adhesion molecule in the fly brain. [Nature Communications] |
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| Scientists found that Polycomb repressive complex 2 (PRC2) interacted with the nucleic acid–binding protein Ybx1. In neural progenitor cells, Ybx1 controlled self-renewal and neuronal differentiation. [Nature Communications] |
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| Investigators screened a panel of tripartite motif (TRIM) family proteins and identified TRIM22 as a potential activator of NF-κB using an NF-κB driven luciferase reporter construct in glioblastoma cell lines. [Cell Death & Differentiation] |
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| Investigators showed a population of ameboid microglia migrating from the ventricular zone into the corpus callosum during early postnatal development, phagocytosing viable oligodendrocyte progenitor cells before onset of myelination. [Cell Reports] |
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| Investigators explored the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. They indicated that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions. [Scientific Reports] |
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| The authors showed that heterogeneous glioblastoma cells express TNTs upon oxidative stress and temozolomide/ionizing radiation treatment. [iScience] |
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| The authors evaluate the potential benefits to the immune system that arise by taking advantage of some of the brain’s unique features, such as its capacity to integrate and synchronize physiological functions, its predictive capacity and its speed of response. [Nature Reviews Immunology] |
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| Scientists provide an overview of the role of astrocytes in CNS inflammation, highlighting recent discoveries on astrocyte subsets and the mechanisms that control them. [Trends in Immunology] |
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| The authors discuss how to bridge transcriptional states to specific functions so we can develop therapies to mediate negative effects of altered microglia–astrocyte interactions. [Trends in Immunology] |
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| The FDA approved Genentech’s EnspryngTM as the first and only subcutaneous treatment for adults living with anti-aquaporin-4 antibody positive neuromyelitis optica spectrum disorder. [Genentech] |
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| September 8 – September 11 Virtual |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| Nanyang Technological University – Singapore, Singapore |
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| Klinikum rechts der Isar of the Technische Universität München – Munich, Germany |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| Nanyang Technological University – Singapore, Singapore |
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| Nanyang Technological University – Singapore, Singapore |
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