Neural Cell News Volume 14.32 | 26 Aug 2020

May 12, 2022

NCN 14.32 | 26 Aug 2020

Neural Cell News by STEMCELL Technologies

Vol. 14.32 – 26 August, 2020

TOP STORY

A Discrete Serotonergic Circuit Regulates Vulnerability to Social Stress

The authors identified a distinct, anatomically and functionally defined serotonergic subpopulation in the dorsal raphe that projects to the ventral tegmental area.
[Nature Communications]

Full Article

Request your free copy of the 'Building Three-Dimensional Human Brain Organoids' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Frataxin
Gene Editing Rescues Friedreich’s Ataxia Pathology in Dorsal Root Ganglia Organoid-Derived Sensory Neurons

Bulk and single-cell RNA sequencing showed that dorsal root ganglia (DRG) organoids present a transcriptional signature similar to native DRGs and displayed the main peripheral sensory neuronal and glial cell subtypes.
[Nature Communications]

Full Article

Inositol Monophosphatase 1 (IMPA1)
Mutation in Intellectual Disability Patients Impairs Neurogenesis but Not Gliogenesis

Scientists generated induced pluripotent stem cells from patients and neurotypical controls and differentiated these into hippocampal dentate gyrus-like neurons and astrocytes.
[Molecular Psychiatry]

Abstract

TGF-β1
Modulates Temozolomide Resistance in Glioblastoma via Altered microRNA Processing and Elevated MGMT

TGF-β1 treatment reduced cellular methylguanine DNA methyltransferase levels through suppressing the expression of miR-198. TGF-β1 upregulation did not affect K-homology splicing regulatory protein expression in glioma cells.
[Neuro-Oncology]

Abstract

MiR-450a-5p
Strengthens the Drug Sensitivity of Gefitinib in Glioma Chemotherapy via Regulating Autophagy by Targeting EGFR

MiR-450a-5p was observed to synergize with gefitinib to inhibit the proliferation, migration and invasion and induce the apoptosis and autophagy of glioma cells.
[Oncogene]

Full Article

E2F7−EZH2 Axis Regulates PTEN/AKT/mTOR Signaling and Glioblastoma Progression

Functional studies showed that E2F7 promoted cell proliferation, cell-cycle progression, cell metastasis and tumorigenicity abilities in vitro and in vivo.
[British Journal of Cancer]

Abstract

The
Different Role of YKL-40 in Glioblastoma Is a Function of MGMT Promoter Methylation Status

The authors performed in vitro and in vivo experiments, six human IDH1/2 wild-type glioblastoma stem-like cells were established and studied to determine a potential interaction of YKL-40 and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation.
[Cell Death & Disease]

Full Article

TRPV4
Activates the Cdc42/N-Wasp Pathway to Promote Glioblastoma Invasion by Altering Cellular Protrusions

Transient receptor potential vanilloid 4 (TRPV4) strongly colocalized and interacted with skeletal protein-F-actin at cellular protrusions, and TRPV4 regulated the formation of invadopodia and filopodia in glioblastoma cells.
[Scientific Reports]

Full Article

Fenpropathrin
Induces Degeneration of Dopaminergic Neurons via Disruption of the Mitochondrial Quality Control System

Fenpropathrin increased the generation of reactive oxygen species, disrupted both mitochondrial function and dynamic networks, impaired synaptic communication, and promoted mitophagy in vitro.
[Cell Death Discovery]

Full Article

STEMCELL's Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells.

REVIEWS

Steps towards Standardized Quantification of Adult Neurogenesis

The authors review the importance of stereology, and propose why and how it should be applied to the study of adult neurogenesis.
[Nature Communications]

Full Article

INDUSTRY AND POLICY NEWS

Cyclerion
Announces Translational Research Award from the Alzheimer’s Association Part the Cloud-Gates Partnership Grant Program

Cyclerion Therapeutics, Inc. announced that it has been awarded a grant from the Alzheimer’s Association’s Part the Cloud-Gates Partnership Grant Program. This award will support their upcoming Phase II trial of IW-6463 in Alzheimer’s Disease with vascular pathology.
[Cyclerion Therapeutics, Inc. ]

Press Release

FEATURED EVENT

A Discrete Serotonergic Circuit Regulates Vulnerability to Social Stress

Frataxin
Gene Editing Rescues Friedreich’s Ataxia Pathology in Dorsal Root Ganglia Organoid-Derived Sensory Neurons

Inositol Monophosphatase 1 (IMPA1)
Mutation in Intellectual Disability Patients Impairs Neurogenesis but Not Gliogenesis

TGF-β1
Modulates Temozolomide Resistance in Glioblastoma via Altered microRNA Processing and Elevated MGMT

MiR-450a-5p
Strengthens the Drug Sensitivity of Gefitinib in Glioma Chemotherapy via Regulating Autophagy by Targeting EGFR

E2F7−EZH2 Axis Regulates PTEN/AKT/mTOR Signaling and Glioblastoma Progression

The
Different Role of YKL-40 in Glioblastoma Is a Function of MGMT Promoter Methylation Status

TRPV4
Activates the Cdc42/N-Wasp Pathway to Promote Glioblastoma Invasion by Altering Cellular Protrusions

Fenpropathrin
Induces Degeneration of Dopaminergic Neurons via Disruption of the Mitochondrial Quality Control System

Steps towards Standardized Quantification of Adult Neurogenesis

Cyclerion
Announces Translational Research Award from the Alzheimer’s Association Part the Cloud-Gates Partnership Grant Program

CAR-T Beyond Oncology Digital Event

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Postdoctoral Researcher – Neurobiology and Neurodegeneration Research

Project Officer – Spinal Cord Injury and Neural Tissue Engineering

Postdoctoral Research Fellow – Molecular Neuroscience

Postdoctoral Research Fellow – Brain Tumor Dormancy/Metastasis

Research Fellow – Neural Cell Therapy

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