 | | Vol. 14.35 – 16 September, 2020 |
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| Investigators performed correlative X-ray holographic nano-tomography and electron microscopy to reconstruct hundreds of cortical pyramidal cells and showed that more superficial cells receive stronger synaptic inhibition on their apical dendrites.
[Nature Neuroscience] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In neonatal mice and cultured differentiating oligodendrocytes, sublethal intermittent hypoxic stress activated cyclophilin D–dependent mitochondrial proton leak and uncoupled mitochondrial respiration, leading to transient bioenergetic stress.
[Journal of Clinical Investigation] |
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| The authors investigated the role of canonical Wnt/β‐catenin signaling in dendritogenesis of adult‐born neurons.
[EMBO Journal] |
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| CircASAP1 expression was significantly up-regulated in recurrent glioblastoma (GBM) tissues and temozolomide-resistant cell lines. CircASAP1 overexpression enhanced GBM cell proliferation and temozolomide-resistance, which was reduced by circASAP1 knockdown.
[Neuro-Oncology] |
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| Investigators showed that centrioles were amplified via centriole rosette formation in both embryonic development and turnover of the olfactory epithelium in adult mice, and rosette-bearing cells often had free centrioles in addition.
[PLoS Biology] |
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| Researchers demonstrated across different metabolic stress conditions that modulate malonyl-CoA levels in cortical neurons that carnitine palmitoyltransferase 1C (CPT1C) regulated the trafficking of the major AMPA receptor subunit, GluA1, through the phosphatidyl-inositol-4-phosphate phosphatase SAC1.
[Journal of Cell Biology] |
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| Scientists found that the chemokines CXCL1 and CCL2 were induced in the brain following herpes simplex virus-1 infection. Ccr2-deficient mice had reduced monocyte recruitment, uncontrolled viral replication, and increased morbidity.
[Cell Reports] |
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| The authors modeled telomere shortening in human hippocampal progenitor cells in vitro using a serial passaging protocol that mimicked the end-replication problem.
[Neuropsychopharmacology] |
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| The authors sought to delineate CASK-mutation consequences and neuronal effects using induced pluripotent stem cell-derived neurons from two mutation carriers.
[Translational Psychiatry] |
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| While prior studies have shown that neuronal cultures possess self-organizing criticality properties, scientists demonstrated that in vitro brain-derived neuronal cultures exhibited a self-optimization phenomenon.
[Scientific Reports] |
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| Researchers investigated a novel hypoxia inducible factor2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glioblastoma.
[Scientific Reports] |
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| Cerebellar granule neurons were plated on poly-L-lysine overnight, and neurite length was determined after one hour treatment with L1 cell adhesion molecule (L1) alone or L1 and bilirubin.
[Pediatric Research] |
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| The authors describe how glial cells play a role in adult hippocampal neurogenesis in both health and disease, especially focusing on glia‐derived factors.
[European Journal of Neuroscience] |
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| BostonGene Corporation announced a scientific collaboration with Brigham and Women’s Hospital. In this collaboration, BostonGene provides the analysis of whole transcriptome sequencing data sets generated from tumor and blood samples from patients with recurrent glioblastoma treated with an oncolytic virus as part of a Phase I clinical trial
[BostonGene Corporation] |
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| CuraSen Therapeutics, Inc. announced that it has dosed its first subjects in a multi-part, Phase I clinical study with CST-2032, the company’s first proprietary compound intended for the treatment of neurodegenerative disease.
[CuraSen Therapeutics, Inc.] |
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| Brainstorm Cell Therapeutics Inc. announced that the Japanese Patent Office has granted Brainstorm’s Japanese Patent, number: 6,753,887, titled: ‘Methods of Generating Mesenchymal Stem Cells which Secrete Neurotrophic Factors’.
[Brainstorm Cell Therapeutics Inc.] |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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