Neural Cell News Volume 14.36 | Sep 23 2020

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    2020-09-23 | NCN 14.36


    Neural Cell News by STEMCELL Technologies
    Vol. 14.36 – 23 September, 2020
    TOP STORY

    Epineural Optogenetic Activation of Nociceptors Initiates and Amplifies Inflammation

    Researchers report a neurotechnology for selective epineural optogenetic neuromodulation of nociceptors and demonstrated that nociceptor activation drove both protective pain behavior and inflammation.
    [Nature Biotechnology]

    AbstractPress Release

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    PUBLICATIONSRanked by the impact factor of the journal

    Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

    The authors developed light-sensitive human retinal organoids with multiple nuclear and synaptic layers and functional synapses.
    [Cell]

    Full ArticleGraphical Abstract

    Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

    Scientists investigated the susceptibility of human iPSC-derived monolayer brain cells and region-specific brain organoids to SARS-CoV-2 infection.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs

    Investigators revealed insights into the activity of microRNAs miR-9/9 and miR-124 as reprogramming agents that orchestrated direct conversion of human fibroblasts into motor neurons by first eradicating fibroblast identity and promoting uniform transition to a neuronal state in sequence.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

    Scientists transplanted hESC-derived midbrain dopamine or cortical glutamate neurons into the substantia nigra or striatum of a mouse Parkinson’s disease model and found extensive graft integration with host circuitry
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System

    The authors showed that glia could be reprogrammed to promote morphological and functional regeneration after central nervous system injury in Drosophila via increased glycolysis.
    [Cell Metabolism]

    AbstractPress ReleaseGraphical Abstract

    Specific Hypothalamic Neurons Required for Sensing Conspecific Male Cues Relevant to Inter-male Aggression

    Scientists identified specific hypothalamic neurons required for sensing conspecific male cues relevant to inter-male aggression.
    [Neuron]

    Abstract

    SPT6-Driven Error-Free DNA Repair Safeguards Genomic Stability of Glioblastoma Cancer Stem-Like Cells

    Researchers presented the results of a high-content siRNA microscopy screen, revealing the transcriptional elongation factor SPT6 to be critical for the genomic stability and self-renewal of glioblastoma cancer-stem like cells.
    [Nature Communications]

    Full Article

    Artificial Cells Drive Neural Differentiation

    Scientists suggested that artificial cells were a versatile chassis for the in situ synthesis and on-demand release of chemical signals that elicited desired phenotypic changes of eukaryotic cells, including neuronal differentiation.
    [Science Advances]

    Full ArticlePress Release

    Retromer Regulates the Lysosomal Clearance of MAPT/Tau

    Researchers demonstrated that the autophagy-lysosome axis was the primary mode for the clearance of aggregated species of MAPT using both chemical and genetic approaches in cell models of amyloid MAPT aggregation.
    [Autophagy]

    Abstract

    An Optimized Quantitative Proteomics Method Establishes the Cell Type-Resolved Mouse Brain Secretome

    High‐performance secretome protein enrichment with click sugars method was used to identify the secretory response of brain slices upon LPS‐induced neuroinflammation and to establish the cell type‐resolved mouse brain secretome resource using primary astrocytes, microglia, neurons, and oligodendrocytes.
    [EMBO Journal]

    Full Article

    He knew neuronal cultures should be active. So he invented a new medium. Watch Cedric Bardy's webinar.
    REVIEWS

    Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease

    The authors discuss the current studies using human pluripotent stem cells focused on Alzheimer’s disease (AD), providing convincing evidences that this system is an excellent opportunity to advance in the comprehension of AD pathology, which will be translated to the development of the still missing effective therapies.
    [International Journal of Molecular Sciences]

    Full Article

    INDUSTRY AND POLICY NEWS

    Seelos Therapeutics Announces Sponsored Research Agreement with Duke University for Gene Therapy Studies of SLS-004 in Parkinson’s Disease

    Seelos Therapeutics, Inc. announced the signing of a Sponsored Research Agreement with Duke University to use the MPTP-induced Parkinson’s Disease (PD) mouse model to establish in vivo proof-of-concept study to demonstrate that administration of LV-dCas9-DNMT3A virus can prevent and/or delay PD and test the efficacy and safety of SLS-004.
    [Seelos Therapeutics Inc.]

    Press Release

    Zhittya Genesis Medicine Announces a Potential Major Medical Breakthrough for the Treatment of Parkinson’s Disease

    Zhittya Genesis Medicine, Inc announced that it will initiate clinical trials to test a medical hypothesis that has been advanced over the last five years that Parkinson’s disease may be caused by vascular disruption in the areas of the brain which house the “dopamine-producing neurons”, those neurons which become dysfunctional in patients suffering from this disorder.
    [Zhittya Genesis Medicine, Inc. (GlobeNewswire, Inc)]

    Press Release

    ProMIS Neurosciences to Develop Multivalent Vaccine for Alzheimer’s Disease

    ProMIS Neurosciences, Inc. announced initiation of a program to construct and test a multivalent peptide vaccine for Alzheimer’s disease. The critical first steps in vaccine development was carried out by VIDO-InterVac, a global leader in vaccine research and development.
    [ProMIS Neurosciences, Inc.]

    Press Release

    FEATURED EVENT

    Neurodegenerative Diseases: Biology & Therapeutics

    December 2 – December 4
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    JOB OPPORTUNITIES

    Postdoctoral – Clinical Neuroimmunology

    University Hospital Basel – Basel, Switzerland

    Postdoctoral Training Fellow – Neuroscience

    The Francis Crick Institute – London, United Kingdom

    Senior/Laboratory Research Scientist – Neuroscience

    The Francis Crick Institute – London, United Kingdom

    Postdoctoral Position – Neurodegeneration

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Research Fellow Position – Biophysical Cell Analysis in Neural Stem Cells

    Nanyang Technological University – Singapore, Singapore

    > See All Jobs

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