Neural Cell News Volume 14.37 | Sep 30 2020

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    2020-09-30 | NCN 14.37


    Neural Cell News by STEMCELL Technologies
    Vol. 14.37 – 30 September, 2020
    TOP STORY

    Negative Feedback Control of Neuronal Activity by Microglia

    Scientists showed that microglia were also critical modulators of neuronal activity and associated behavioural responses in mice. Microglia responded to neuronal activation by suppressing neuronal activity, and ablation of microglia amplified and synchronized the activity of neurons, leading to seizures.
    [Nature]

    Abstract

    The complex genettics of schizophrenia are unclear. So she developed a new approach.
    PUBLICATIONSRanked by the impact factor of the journal

    Neuronal Defects in a Human Cellular Model of 22q11.2 Deletion Syndrome

    Using electrophysiology and live imaging, the authors identified defects in spontaneous neuronal activity and calcium signaling in both organoid- and 2D-derived cortical neurons.
    [Nature Medicine]

    AbstractFull Article
    Press Release

    CLR01 Protects Dopaminergic Neurons In Vitro and in Mouse Models of Parkinson’s Disease

    Investigators report that the molecular tweezer CLR01 decreased aggregation and toxicity in induced pluripotent stem cell-derived dopaminergic cultures treated with Parkinson’s disease brain protein extracts.
    [Nature Communications]

    Full Article

    Single-Nucleus Transcriptome Analysis Reveals Dysregulation of Angiogenic Endothelial Cells and Neuroprotective Glia in Alzheimer’s Disease

    Researchers showed that a subpopulation of angiogenic endothelial cells was induced in the brain in patients with Alzheimer’s disease. These angiogenic endothelial cells exhibited increased expression of angiogenic growth factors and their receptors and antigen-presentation machinery.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

    The authors identified an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of undifferentiated neural crest-derived progenitors through the repression of DLG2, a candidate tumor suppressor gene in neuroblastoma.
    [Cell Reports]

    Full ArticleGraphical Abstract

    LncRNA BCYRN1 Inhibits Glioma Tumorigenesis by Competitively Binding with miR-619-5p to Regulate CUEDC2 Expression and the PTEN/AKT/p21 Pathway

    Investigators uncovered a differentially expressed lncRNA called brain cytoplasmic RNA 1 (BCYRN1), and elucidated its function and molecular mechanism in the progression and development of glioma.
    [Oncogene]

    Full Article

    Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

    Scientists systematically investigated the expression profiles of 1,436 murine RNA-binding proteins in the developing mouse brain and identified quaking (Qk) as a marker of the putative glial precursor cells population.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Oxygen Glucose Deprivation/Re-Oxygenation-Induced Neuronal Cell Death Is Associated with Lnc-D63785 m6A Methylation and miR-422a Accumulation

    In SH-SY5Y cells and primary murine neurons, researchers report that oxygen glucose deprivation/re-oxygenation induced the accumulation of the microRNA miR-422a, leading to downregulation of miR-422a targets myocyte enhancer factor-2D and mitogen-activated protein kinase kinase 6.
    [Cell Death & Disease]

    Full Article

    Tristetraprolin Destabilizes NOX2 mRNA and Protects Dopaminergic Neurons from Oxidative Damage in Parkinson’s Disease

    To explore the role of tristetraprolin in Parkinson’s disease (PD), an in vitro 1‐methyl‐4‐phenylpyridinium cell model and an in vivo 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine of PD were used.
    [FASEB Journal]

    Full Article

    Regulation of Degenerative Spheroids after Injury

    Using neonatal mouse primary sympathetic neurons, scientists investigated the roles of players previously implicated in the progression of Wallerian degeneration in injury-induced spheroid formation.
    [Scientific Reports]

    Full Article

    Oxidative Switch Drives Mitophagy Defects in Dopaminergic Parkin Mutant Patient Neurons

    Researchers generated induced neuronal progenitor cells from PRKN mutant patient fibroblasts with a high dopaminergic neuron yield.
    [Scientific Reports]

    Full Article


    He knew neuronal cultures should be active. So he invented a new medium. Watch Cedric Bardy's webinar.
    REVIEWS

    Glial Cells in the Driver Seat of Leukodystrophy Pathogenesis

    The authors take a closer look at multiple leukodystrophies, classified based on the primary glial cell type that is affected.
    [Neurobiology of Disease]

    Full Article

    Dietary Docosahexaenoic Acid Inhibits Neurodegeneration and Prevents Stroke

    Investigators describe the effects of dietary docosahexaenoic acid on ischemic stroke‐associated neuronal damage and its role in stroke prevention.
    [Journal of Neuroscience Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    Neuronetics® Celebrates 500,000 Treatment Milestone for Greenbrook® TMS

    Neuronetics®, Inc. congratulated Greenbrook® TMS, Inc., a NeuroStar® Advanced Therapy provider with 125 treatment centers across the US, for delivering its 500,000th transcranial magnetic stimulation treatment.
    [Neuronetics, Inc.]

    Press Release

    Aclipse Therapeutics Awarded AUD 1 Million Grant from FightMND

    Aclipse Therapeutics Inc. was awarded an AUD 1 million drug development research grant from FightMND, the largest independent funder of amyotrophic lateral sclerosis research in Australia.
    [Aclipse Therapeutics Inc (BusinessWire, Inc)]

    Press Release

    FEATURED EVENT

    10 Million Reasons to Defeat Cancer 2020 – Abbott World Summit

    October 13 – October 14
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    JOB OPPORTUNITIES

    Research Scientist – Neurodegeneration

    UCB S.A. – Braine L’alleud, Belgium

    Researcher – Neurodegenerative Disease

    The University of Chicago – Chicago, Illinois, United States

    Postdoctoral Position – Neuroscience, Stem Cell Biology

    Albert Einstein College of Medicine – New York, New York, United States

    Research Fellow – Behavior Neuroscience

    Mayo Clinic Health System – Rochester, California, United States

    PhD Position – Cognitive Neuroscience

    Max Planck Institute for Human Cognitive and Brain Sciences – Leipzig, Germany

    > See All Jobs

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