Scientists showed that microglia were also critical modulators of neuronal activity and associated behavioural responses in mice. Microglia responded to neuronal activation by suppressing neuronal activity, and ablation of microglia amplified and synchronized the activity of neurons, leading to seizures. [Nature]
Using electrophysiology and live imaging, the authors identified defects in spontaneous neuronal activity and calcium signaling in both organoid- and 2D-derived cortical neurons. [Nature Medicine]
Investigators report that the molecular tweezer CLR01 decreased aggregation and toxicity in induced pluripotent stem cell-derived dopaminergic cultures treated with Parkinson’s disease brain protein extracts. [Nature Communications]
Researchers showed that a subpopulation of angiogenic endothelial cells was induced in the brain in patients with Alzheimer’s disease. These angiogenic endothelial cells exhibited increased expression of angiogenic growth factors and their receptors and antigen-presentation machinery. [Proceedings of the National Academy of Sciences of the United States of America]
The authors identified an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of undifferentiated neural crest-derived progenitors through the repression of DLG2, a candidate tumor suppressor gene in neuroblastoma. [Cell Reports]
Investigators uncovered a differentially expressed lncRNA called brain cytoplasmic RNA 1 (BCYRN1), and elucidated its function and molecular mechanism in the progression and development of glioma. [Oncogene]
Scientists systematically investigated the expression profiles of 1,436 murine RNA-binding proteins in the developing mouse brain and identified quaking (Qk) as a marker of the putative glial precursor cells population. [Stem Cell Reports]
In SH-SY5Y cells and primary murine neurons, researchers report that oxygen glucose deprivation/re-oxygenation induced the accumulation of the microRNA miR-422a, leading to downregulation of miR-422a targets myocyte enhancer factor-2D and mitogen-activated protein kinase kinase 6. [Cell Death & Disease]
To explore the role of tristetraprolin in Parkinson’s disease (PD), an in vitro 1‐methyl‐4‐phenylpyridinium cell model and an in vivo 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine of PD were used. [FASEB Journal]
Using neonatal mouse primary sympathetic neurons, scientists investigated the roles of players previously implicated in the progression of Wallerian degeneration in injury-induced spheroid formation. [Scientific Reports]
Researchers generated induced neuronal progenitor cells from PRKN mutant patient fibroblasts with a high dopaminergic neuron yield. [Scientific Reports]
The authors take a closer look at multiple leukodystrophies, classified based on the primary glial cell type that is affected. [Neurobiology of Disease]
Investigators describe the effects of dietary docosahexaenoic acid on ischemic stroke‐associated neuronal damage and its role in stroke prevention. [Journal of Neuroscience Research]
Neuronetics®, Inc. congratulated Greenbrook® TMS, Inc., a NeuroStar® Advanced Therapy provider with 125 treatment centers across the US, for delivering its 500,000th transcranial magnetic stimulation treatment. [Neuronetics, Inc.]
Aclipse Therapeutics Inc. was awarded an AUD 1 million drug development research grant from FightMND, the largest independent funder of amyotrophic lateral sclerosis research in Australia. [Aclipse Therapeutics Inc (BusinessWire, Inc)]