 | | Vol.14.42 – 4 November, 2020 |
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| Scientists showed that BrainPhys™ Imaging improves the quality of a wide range of fluorescence imaging applications with live neurons in vitro while supporting optimal neuronal viability and function.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed cerebral organoid models using induced pluripotent stem cells (iPSCs) with APOE ε3/ε3 or ε4/ε4 genotype from individuals with either normal cognition or Alzheimer’s disease dementia.
[Nature Communications] |
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| Scientists identified a regional regulator Filia, which was predominantly expressed in mouse hippocampal neural stem/progenitor cells after birth and regulates DNA double-strand breaks formation and repair.
[Science Advances] |
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| The authors explored the autophagy-inducing mechanisms that underlay the autophagic cell death-triggering compound loperamide in glioblastoma cells.
[Journal of Autophagy] |
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| Investigators identified a profound dysregulation in the expression of relevant spliceosome components and splicing factors in cohorts of human high-grade astrocytomas, mostly glioblastomas, compared to healthy brain control samples, being SRSF3, RBM22, PTBP1 and RBM3 able to perfectly discriminate between tumors and control samples, and between proneural-like or mesenchymal-like tumors versus control samples from different mouse models with gliomas.
[Brain] |
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| Researchers showed that the Special AT‐rich Binding Protein‐2 (SATB2), one of the crucial nuclear matrix‐associated proteins, recruited histone acetyltransferase CBP to promote the FOXM1‐mediated cell proliferation and tumor growth of glioblastoma.
[EMBO Molecular Medicine] |
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| Investigators used optogenetic activation of β-catenin signaling to probe the dynamic responses of differentiating adult neural stem cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists evaluated the ability of anti-Sindbis virus (SINV) E2 antibody to suppress SINV replication in differentiated AP-7 olfactory sensory neuronal cells previously shown to respond to anti-E2 antibody with suppression of virus replication and improved survival.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers showed that olfactory ensheathing cells and Schwann cells recognized phosphatidylserine in necrotic bodies, followed by engulfment and trafficking to endosomes and lysosomes. They also showed that both glia could phagocytose and process myelin debris.
[Scientific Reports] |
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| The authors used CRISPR/Cas9 to induce knockout of PHF6 in SK-N-BE cells which were then differentiated to neuron-like cells in order to model nervous system related consequences of PHF6 loss.
[Scientific Reports] |
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| Investigators describe the efforts to recapitulate brain development in neural organoids and focus on their applicability for disease modeling, evolutionary studies and neural network research.
[Nature Neuroscience] |
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| The authors summarize recent findings that shed light on how oligodendrocyte lineage cells might participate in the pathogenesis of depression, and discuss new approaches for targeting these cells as a novel strategy to treat depression.
[Molecular Psychiatry] |
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| Niches are specialized tissue microenvironments which control stem cells functioning. Investigators review recent progress in our understanding of sensory nerves biology in the stem cell niche.
[Stem Cells Translational Medicine] |
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| Neuraly, Inc. received clearance of an investigational new drug application to initiate a Phase IIb trial of NLY01 in patients with Alzheimer’s disease. NLY01 was also being evaluated in patients with Parkinson’s disease in a Phase II trial initiated in February 2020.
[Neuraly, Inc.(Business Wire Inc)] |
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| InnoCare Pharma announced the Investigational New Drug clearance of its Bruton’s tyrosine kinase inhibitor orelabrutinib by the US FDA for starting Phase II clinical investigations in MS in the United States.
[InnoCare Pharma] |
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| January 25 – January 28, 2021
Virtual |
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| | University of Sussex – Sussex, England, United Kingdom |
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| | Yale School of Medicine – West Haven, Connecticut, United States |
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| | Harvard Medical School and Brigham & Women’s Hospital – Boston, Massachusetts, United States |
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| | Flanders Institute for Biotechnology – Leuven, Belgium |
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| | The University of Tennessee Health Science Cente – Memphis, Tennessee, United States |
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