Neural Cell News Volume 14.44 | Nov 25 2020

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    2020-11-25 | NCN 14.44


    Neural Cell News by STEMCELL Technologies
    Vol. 14.44 – 25 November, 2020
    TOP STORY

    Gga3 Deletion and a GGA3 Rare Variant Associated with Late Onset Alzheimer’s Disease Trigger BACE1 Accumulation in Axonal Swellings

    Researchers showed that BACE pharmacological inhibition ameliorates β-site APP-cleaving enzyme 1 (BACE1) axonal trafficking and diminishes axonal dystrophies in Gga3 null neurons in vitro and in vivo.
    [Science Translational Medicine]

    Full ArticleEditorial

    Download an e-book covering the evolution of organoids, from their development to updated applications and future outlooks.
    PUBLICATIONSRanked by the impact factor of the journal

    Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain

    Using viral tracing and whole-brain imaging, investigators reconstructed the three-dimensional architecture of the hypothalamo-neurohypophysial system and observed collaterals of magnocellular neuroendocrine cells within the brain.
    [Neuron]

    AbstractGraphical Abstract

    Transformative Network Modeling of Multi-Omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

    ATP6V1A was identified as a key regulator of a top-ranked neuronal subnetwork, and its role in disease-related processes was evaluated through CRISPR-based manipulation in human induced pluripotent stem cell-derived neurons and RNAi-based knockdown in Drosophila models.
    [Neuron]

    AbstractGraphical Abstract

    The Potassium Channel Subunit Kvβ1 Serves as a Major Control Point for Synaptic Facilitation

    Scientists overcame size barriers by combining high-resolution optical recordings of membrane potential, exocytosis, and Ca2+ in cultured hippocampal neurons.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Demyelination Regulates the Circadian Transcription Factor BMAL1 to Signal Adult Neural Stem Cells to Initiate Oligodendrogenesis

    Investigators showed that within demyelinating lesions, astrocyte circadian clocks produced the Wnt inhibitors SFRP1 and SFRP5. Unexpectedly, SFRP1 and SFRP5 signaled to the subventricular zone (SVZ) to reduce the circadian transcription factor BMAL1. This sequence of events caused adult neural stem cells in the SVZ to differentiate into oligodendrocyte lineage cells, which were then supplied to demyelinated lesions.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Raloxifene Prevents Stress Granule Dissolution, Impairs Translational Control and Promotes Cell Death during Hypoxia in Glioblastoma Cells

    A screen of 1120 FDA-approved drugs identified 129 candidates that delayed the dissolution of hypoxia-induced stress granules (SGs) following a return to normoxia. Amongst these candidates, the selective estrogen receptor modulator raloxifene delayed SG dissolution in a dose-dependent manner.
    [Cell Death & Disease]

    Full Article

    The HIF1α/HIF2α-miR210-3p Network Regulates Glioblastoma Cell Proliferation, Dedifferentiation and Chemoresistance through EGF under Hypoxic Conditions

    In a hypoxic microenvironment, the hypoxia-inducible factor 1α (HIF1α)/HIF2α-miR210-3p network promoted the malignant progression of glioblastoma through a positive feedback loop with epidermal growth factor (EGF).
    [Cell Death & Disease]

    Full Article

    Role of RPTPβ/ζ in Neuroinflammation and Microglia-Neuron Communication

    The authors tested if Receptor Protein Tyrosine Phosphatase (RPTP)/ζ was involved in the modulation of neuroinflammatory responses using specific inhibitors of RPTPβ/ζ.
    [Scientific Reports]

    Full Article

    Embryonic Periventricular Endothelial Cells Demonstrate a Unique Pro-Neurodevelopment and Anti-Inflammatory Gene Signature

    Researchers conducted comparative transcriptome analysis of mouse periventricular endothelial cells vs. adult brain endothelial cells in mono-culture or neural progenitor cells co-culture.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Bidirectional Learning in Upbound and Downbound Microzones of the Cerebellum

    The author review the current understanding of the changes in the activity of cerebellar Purkinje cells in different ‘microzones’ during various forms of learning. In addition, describes an emerging model that indicates that the activity of each microzone is bound to either increase or decrease during the initial stages of learning, depending on the directional and temporal demands of its downstream circuitry and the behavior involved.
    [Nature Reviews Neuroscience]

    Abstract

    Extracellular Vesicle-Mediated Bilateral Communication between Glioblastoma and Astrocytes

    Scientists focus on recent findings on extracellular vesicle-mediated bilateral crosstalk, between glioblastoma cells and astrocytes, highlighting the protumor and antitumor roles of astrocytes in glioblastoma development.
    [Trends in Neuroscience]

    Abstract

    INDUSTRY AND POLICY NEWS

    Alzprotect Strengthens Its Intellectual Property Portfolio for Its First-in-Class Clinical Stage Drug Ezeprogind

    Alzprotect annouced that the United States Patent and Trademark Office granted patent number US 10,772,884 concerning the therapeutic uses of its first-in-class clinical stage drug Ezeprogind in the treatment of tauopathies.
    [Alzprotect]

    Press Release

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Senior Scientific Researcher – In Vitro Human Brain Modeling

    Genentech, Inc. – South San Francisco, California, United States

    Research Associate – Single Cell Epigenetics, Brain

    Imperial College London – London, England, United Kingdom

    Scientific Director – Neuroscience

    Max Planck Florida Institute for Neuroscience – Jupiter, Florida, United States

    Postdoctoral Research Fellow – Alzheimer’s & Neurodegenerative Diseases

    The University of Texas Health Science Center at San Antonio – San Antonio, Texas, United States

    Postdoctoral Fellow – Alzheimer’s Disease

    The University of Texas Health Science Center at San Antonio – San Antonio, Texas, United States

    > See All Jobs

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