 | | Vol. 15.00 – 6 January, 2021 |
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| Using high-throughput flow cytometry screening, single-cell RNA sequencing, and CRISPR–Cas9-based cell-specific in vivo genetic perturbations in mice, the authors identified a subset of astrocytes that expressed the lysosomal protein LAMP12 and the death receptor ligand TRAIL.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established two highly penetrant human neural stem cell-derived malignant glioma models, which resembled the histopathology and transcriptional heterogeneity of human glioblastoma.
[Cell Research] |
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| Investigators showed that triplication of homologous chromosome 21 genes aggravated neuroinflammation in combined murine Down syndrome-Alzheimer’s disease models.
[Science Advances] |
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| The authors report a nanoparticle platform for blood-brain barrier (BBB) pathophysiology–independent delivery of small interfering RNA (siRNA) in traumatic brain injury.
[Science Advances] |
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| Investigators showed that integrin αV/β1 receptor bound recombinant human Tau, mediating the entry of Tau fibrils in astrocytes.
[Nature Communications] |
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| Scientists used single-cell RNA-seq in morphologically identified parvalbumin interneurons and studied their transcriptomic states in the morphological, physiological, and developmental domains.
[Nature Communications] |
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| Investigators report that TDP-43 aggregation in neuronal cells of mouse and human origin caused sensitivity to oxidative stress.
[Nature Structural & Molecular Biology] |
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| By repeatedly differentiating and applying single-cell RNA (scRNA-seq) to motor neurons from healthy, familial ALS, sporadic ALS, and genome-edited iPSC lines across multiple patients, batches, and platforms, scientists accounted for genetic and experimental variability toward identifying unified and reproducible ALS signatures.
[Cell Systems] |
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| Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
[Cell Reports] |
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| The authors described a detrimental role of ApoE4 in regulating fatty acid (FA) metabolism across neurons and astrocytes in tandem with their distinctive mitochondrial phenotypes. ApoE4 disrupted neuronal function by decreasing FA sequestering in lipid droplets.
[Cell Reports] |
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| Scientists investigated the potential interaction between zinc finger E-box binding homeobox 2 (ZEB2) and microRNA-637 (miR-637) and its downstream signaling pathway in glioma. The results revealed that ZEB2 could directly bind to the E-box elements in the miR-637 promoter and promoted cell proliferation, migration, and invasion via miR-637 downregulation.
[Molecular Therapy-Nucleic Acids] |
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| Researchers evaluated Parkinson’s disease patient plasma for evidence of inflammasome activity. Multiple circulating inflammasome proteins were detected almost exclusively in extracellular vesicles indicative of ongoing inflammasome activation and pyroptosis.
[npj Parkinson’s Disease] |
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| Investigators developed a ‘two-cell’ model of glucose metabolism, which can explain the effects of electroconvulsive therapy and the beneficial and side effects of olanzapine treatment.
[Molecular Psychiatry] |
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| Passage Bio, Inc. announced that the FDA has cleared an investigational new drug (IND) application for the company’s lead product candidate, PBGM01, an adeno-associated virus-delivery gene therapy that is being studied for the treatment of infantile GM1 gangliosidosis.
[Passage Bio, Inc.] |
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| BioXcel Therapeutics, Inc. announced that BXCL501, the company’s proprietary, orally dissolving thin film formulation of dexmedetomidine, met the primary and secondary endpoints of the TRANQUILITY trial at the 60 mcg dose level.
[BioXcel Therapeutics, Inc.] |
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| | German Center for Neurodegenerative Diseases – Bonn, Germany |
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| | University of Luxembourg – Belval, Luxembourg |
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| | University of Luxembourg – Belval, Luxembourg |
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| | University of Virginia – Charlottesville, Virginia, United State |
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| | UT Southwestern Medical Center – Dallas, Texas, United States |
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