Neural Cell News Volume 15.01 | Jan 13 2021

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    2021-01-13 | NCN 15.01


    Neural Cell News by STEMCELL Technologies
    Vol. 15.01 – 13 January, 2021
    TOP STORY

    STING Controls Nociception via Type I Interferon Signaling in Sensory Neurons

    Investigators demonstrated that STING to be a critical regulator of nociception through type-I interferon signaling in peripheral nociceptive sensory neurons.
    [Nature]

    Abstract


    Her 'mini-brains' creation was unexpected. Her protocol was groundbreaking. Watch Madeline Lancaster's webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Molecular Characterization of Selectively Vulnerable Neurons in Alzheimer’s Disease

    To identify and characterize selectively vulnerable neuronal populations, the authors used single-nucleus RNA sequencing to profile the caudal entorhinal cortex and the superior frontal gyrus—brain regions where neurofibrillary inclusions and neuronal loss occurred early and late in Alzheimer’s disease (AD), respectively—from postmortem brains spanning the progression of AD-type tau neurofibrillary pathology.
    [Nature Neuroscience]

    AbstractPress Release

    Neuronal Delivery of Antibodies Has Therapeutic Effects in Animal Models of Botulism

    Researchers harnessed the structural and trafficking properties of an atoxic derivative of botulinum neurotoxin (BoNT) to transport a function-blocking single-domain antibody into the neuronal cytosol where it could inhibit BoNT serotype A molecular toxicity.
    [Science Translational Medicine]

    AbstractEditorial

    Differential Contribution of Transcriptomic Regulatory Layers in the Definition of Neuronal Identity

    Scientists generated profiles for the three regulatory layers from developmentally and regionally distinct subpopulations of neurons from the mouse hippocampus and broader nervous system.
    [Nature Communications]

    Full Article

    A Logical Network-Based Drug-Screening Platform for Alzheimer’s Disease Representing Pathological Features of Human Brain Organoids

    The authors report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of Alzheimer’s disease with human induced pluripotent stem cell-derived cerebral organoids, including CRISPR-Cas9-edited isogenic lines.
    [Nature Communications]

    Full Article

    Neuroinvasion of SARS-CoV-2 in Human and Mouse Brain

    Scientists used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. Using human brain organoids, they observed clear evidence of infection with accompanying metabolic changes in infected and neighboring neurons.
    [Journal of Experimental Medicine]

    Full Article
    Graphical AbstractEditorial

    Stem-Cell-Derived Human Microglia Transplanted into Mouse Brain To Study Human Disease

    Researchers detailed an accurate, step-by-step workflow that includes in vitro microglia differentiation from human pluripotent stem cells, transplantation into the mouse brain and quantitative analysis of engraftment.
    [Nature Protocols]

    Abstract

    ALK Ligand ALKAL2 Potentiates MYCN-Driven Neuroblastoma in the Absence of ALK Mutation

    Scientists tested whether anaplastic lymphoma kinase AL2 (ALKAL2) ligand could potentiate neuroblastoma progression in the absence of ALK mutation
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Multiple Signaling Pathways Are Essential for Synapse Formation Induced by Synaptic Adhesion Molecules

    To explore what signaling pathways may be involved, investigators employed heterologous synapse formation assays in which a synaptic adhesion molecule expressed in a nonneuronal cell induced pre- or postsynaptic specializations in cocultured neurons.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    A Three-Dimensional In Vitro Model of the Peripheral Nervous System

    Scientists present an in vitro model of the peripheral nervous system by establishing a coculture model of motor neurons and Schwann cells in a 3D environment in a microengineered extracellular matrix hydrogel scaffold.
    [NPG Asia Materials]

    Full Article

    Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

    Expression data from developmental and adult neurogenesis showed relative enrichment of Notch and γ-secretase expression in stem cells, whereas expression of APP and β-secretase was enriched in neurons.
    [Cell Reports]

    Full ArticleGraphical Abstract

    MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

    Researchers observed that monocarboxylate transporter 1 (MCT1) loss from oligodendrocyte lineage cells was dispensable for normal myelination and axonal energy homeostasis early in life.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Explore scientific events this January with the Science Events Calendar.
    REVIEWS

    Neurexins: Molecular Codes for Shaping Neuronal Synapses

    The authors propose a conceptual framework for how combinations of synaptic protein isoforms act as ‘senders’ and ‘readers’ to instruct synapse formation and the acquisition of cell type-specific and synapse-specific functional properties.
    [Nature Reviews Neuroscience]

    Abstract

    The Role of E3 Ubiquitin Ligases in the Development and Progression of Glioblastoma

    Scientists consider how knowledge of E3 ligase biology may be used for future therapeutic interventions in glioblastoma, including the use of blood-brain barrier permeable proteolysis targeting chimeras.
    [Cell Death & Differentiation]

    Full ArticleGraphical Abstract

    The Roles of Microglia in Viral Encephalitis: From Sensome to Therapeutic Targeting

    Investigators summarize the current knowledge on the role of microglia in viral encephalitis, propose questions to be answered in the future and suggest possible therapeutic targets.
    [Cellular & Molecular Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Cognito Therapeutics Receives FDA Breakthrough Device Designation for Next-Generation Digital Therapeutic in Alzheimer’s Disease

    Cognito Therapeutic. Inc. announced its lead product has received Breakthrough Device Designation from the FDA for the treatment of cognitive and functional symptoms associated with Alzheimer’s disease.
    [Cognito Therapeutic. Inc. (Business Wire, Inc.)]

    Press Release

    New Treatment for Central Nervous System Tumors Enters Phase I Clinical Trials

    OX2 Therapeutics, Inc. announced that they treated their first patient in a Phase I human trial of a new treatment developed to combat recurrent high-grade brain tumors.
    [OX2 Therapeutics, Inc. (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    Integrating Metabolism and Immunity

    January 25 – 28, 2021
    Virtual

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    JOB OPPORTUNITIES

    Staff Scientist – Medulloblastoma

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Research Fellow – Clinical and Movement Neurosciences

    University College London – London, England, United Kingdom

    Scientist / Assistant Professor – Neuroscience

    Hospital for Sick Children; University of Toronto – Toronto, Ontario, Canada

    Postdoctoral Associate – Brain Control of Metabolism

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Position – Pharmacogenomics for Glioma

    Luxembourg Institute of Healtht – Luxembourg, Luxembourg

    > See All Jobs

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