Neural Cell News Volume 15.02 | Jan 20 2021

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    2021-01-20 | NCN 15.02


    Neural Cell News by STEMCELL Technologies
    Vol. 15.02 – 20 January, 2021
    TOP STORY

    Pathway-Based Classification of Glioblastoma Uncovers a Mitochondrial Subtype with Therapeutic Vulnerabilities

    A computational approach for unbiased identification of core biological traits of single cells and bulk tumors uncovered four tumor cell states and glioblastoma subtypes distributed along neurodevelopmental and metabolic axes, classified as proliferative/progenitor, neuronal, mitochondrial, and glycolytic/plurimetabolic.
    [Nature Cancer]

    AbstractPress Release

    Survey Report: Where Is Pluripotent Stem Cell Research Now?
    PUBLICATIONSRanked by the impact factor of the journal

    O-GlcNAcylation Ameliorates the Pathological Manifestations of Alzheimer’s Disease by Inhibiting Necroptosis

    The links among altered O-linked β-N-acetylglucosaminylation (O-GlcNAcylation), β-amyloid accumulation, and necroptosis are unclear. The authors found that O-GlcNAcylation played a protective role in Alzheimer’s disease by inhibiting necroptosis.
    [Science Advances]

    Full Article

    CGG Repeat RNA G-Quadruplexes Interact with FMRpolyG to Cause Neuronal Dysfunction in Fragile X-related Tremor/Ataxia Syndrome

    Researchers showed that FMRpolyG interacted with pathogenic CGG repeat-derived RNA G-quadruplexes, propagated cell to cell, and induced neuronal dysfunction.
    [Science Advances]

    Full Article

    Transneuronal Delivery of Hyper-Interleukin-6 Enables Functional Recovery after Severe Spinal Cord Injury in Mice

    The authors report the significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This was achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6, a potent designer cytokine stimulating JAK/STAT3 signaling and axon regeneration.
    [Nature Communications]

    Full ArticlePress Release

    BNIP3L/NIX-Mediated Mitophagy Protects Against Glucocorticoid-Induced Synapse Defects

    Researchers investigated the role of glucocorticoids in mitophagy inhibition and subsequent synaptic defects in hippocampal neurons, SH-SY5Y cells, and ICR mice.
    [Nature Communications]

    Full Article

    A Subset of Spinal Dorsal Horn Interneurons Crucial for Gating Touch-Evoked Pain-Like Behavior

    Scientists identified a subset of inhibitory interneurons in the spinal dorsal horn (SDH) operated by adeno-associated viral vectors incorporating a neuropeptide Y promoter (AAV-NpyP+) and showed that specific ablation or silencing of AAV-NpyP+ SDH interneurons converted touch-sensing Aβ fiber-derived signals to morphine-resistant pain-like behavioral responses.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    PIAS1 Modulates Striatal Transcription, DNA Damage Repair, and SUMOylation with Relevance to Huntington’s Disease

    Investigators evaluated the mechanistic contributions of protein inhibitor of activated STAT-1 (PIAS1) in Huntington’s disease (HD) mice and HD patient-derived induced pluripotent stem cells and found a link between PIAS1 and DNA damage repair pathways.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Single-Cell Chromatin Accessibility Profiling of Glioblastoma Identifies an Invasive Cancer Stem Cell Population Associated with Lower Survival

    Researchers showed, using single-cell chromatin accessibility, that primary human glioblastomas (GBMs) harbored a heterogeneous self-renewing population whose diversity was captured in patient-derived GBMs stem cells.
    [eLife]

    Abstract

    Survival Control of Oligodendrocyte Progenitor Cells Requires the Transcription Factor 4 during Olfactory Bulb Development

    Investigators identified that the transcription factor 4-mediated cell death was essential for generating an appropriate number of oligodendrocyte progenitor cells and thereby oligodendrocytes in the olfactory bulb.
    [Cell Death & Disease]

    Full Article

    p53 Is Required for Nuclear but Not Mitochondrial DNA Damage-Induced Degeneration

    Researchers induced selective mitochondrial DNA damage in neuronal axons using microfluidic chambers that allowed for the spatial and fluidic isolation of neuronal cell bodies from the axons.
    [Cell Death & Disease]

    Full Article

    GDF15 Promotes Glioma Stem Cell-Like Phenotype via Regulation of ERK1/2–C-Fos–LIF Signaling

    The authors report that growth differentiation factor 15 (GDF15) promoted the glioma stem cell (GSC)-like phenotype in GSC-like cells through the activation of leukemia inhibitor factor (LIF)–STAT3 signaling.
    [Cell Death Discovery]

    Full Article

    CCAAT/Enhancer-Binding Protein Delta Mediates Glioma Stem-Like Cell Enrichment and ATP-Binding Cassette Transporter ABCA1 Activation for Temozolomide Resistance in Glioblastoma

    Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.
    [Cell Death Discovery]

    Full Article

    STEMCELL's Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells.
    REVIEWS

    Potential Roles of Stem Cell Marker Genes in Axon Regeneration

    Investigators review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity.
    [Experimental and Molecular Medicine]

    Press Release

    INDUSTRY AND POLICY NEWS

    Neurogene and University of Edinburgh Announce Research Collaboration to Advance Next Generation Gene Therapies

    Neurogene, Inc. and University of Edinburgh announced a collaboration to advance development of multiple platform approaches designed to enable next generation gene therapies. The collaboration provides comprehensive research capabilities to Neurogene, enabling the company and the university to expedite a multiple platform approach to improve upon existing gene therapy technologies.
    [Neurogene, Inc.]

    Press Release

    MediciNova Receives Notice of Allowance for New Patent Covering the Combination of MN-166 (Ibudilast) and Riluzole for the Treatment of Amyotrophic Lateral Sclerosis (ALS) in Japan

    MediciNova, Inc announced that it has received a Notice of Allowance from the Japan Patent Office for a pending patent application which covers the combination of ibudilast and riluzole for the treatment of ALS.
    [MediciNova, Inc]

    Press Release

    FEATURED EVENT

    Neuroimmune Models for Alzheimer’s Risk

    January 26, 2021
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    JOB OPPORTUNITIES

    Tenure-Track Assistant / Associate Professor – Neurobiology

    North Carolina State University – Raleigh, North Carolina, United States

    Research Fellow – Pathophysiology of Neurodegenerative Movement Disorders

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowships – Neurophysiology of Substance Use Disorder

    University of Kentucky – Lexington, Kentucky, United States

    Postdoctoral Fellow – Tumor Biology and Therapeutic Applications

    Harvard Medical School – Boston, Massachusetts, United States

    Image Analysis Specialist – Cancer and Chronic Diseases

    Novo Nordisk – Copenhagen, Denmark

    > See All Jobs

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