| Vol. 15.03 – 27 January, 2021 |
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| Scientists showed that in aging mice myeloid cell bioenergetics was suppressed in response to increased signaling by the lipid messenger prostaglandin E2, a major modulator of inflammation. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report a lysosomal K+ channel complex that was activated by growth factors and gated by protein kinase B that they termed lysoKGF. [Nature] |
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| Researchers developed a platform to interrogate the chromatin accessibility landscape and transcriptional program within neurons during degeneration. [Cell] |
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| Investigators used functional and structural in vivo imaging in a mouse model of cortical multiple sclerosis to demonstrate that bouts of cortical inflammation disrupted cortical circuit activity coincident with a widespread, but transient, loss of dendritic spines. [Nature Neuroscience] |
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| The authors demonstrated that astrocytic ApoE vectors a variety of miRNAs, and these miRNAs specifically silence genes involved in neuronal cholesterol biosynthesis, ultimately accounting for the accumulation of the pathway-initiating substrate acetyl-CoA. [Neuron] |
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| Researchers found that murine GD2 CAR-T cells, specific for the tumor-associated antigen GD2, induced fatal neurotoxicity in a costimulatory domain-dependent manner. [Nature Communications] |
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| Scientists identified resistance mechanisms to CDK6 inhibition in hedgehog-associated medulloblastoma by performing orthogonal CRISPR and CRISPR interference screens in medulloblastoma cells treated with a CDK4/6 inhibitor. [Journal of Clinical Investigation] |
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| The authors showed that the differentiation and viability of retinal progenitor cells were severely perturbed in prpf31 knockout zebrafish when compared with other tissues at an early embryonic stage. [Nucleic Acids Research] |
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| Investigators adopted a radiogenomic analysis to screen for functionally relevant genes that orchestrated the process of glioma cell infiltration through myelin and promoted glioblastoma aggressiveness. [Brain] |
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| Scientists developed a new method for isolation and culture of optic nerve-derived oligodendrocyte lineage cells and used it to study oligodendrocyte progenitor cell differentiation. [Autophagy] |
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| Investigators demonstrated that pimozide and loperamide triggered an ATG5- and ATG7 (autophagy related 5 and 7)-dependent type of cell death that was significantly reduced with cathepsin inhibitors and the lipid reactive oxygen species scavenger α-tocopherol in MZ-54 glioblastoma cells. [Autophagy] |
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| Researchers showed that rescuing >20% kisspeptin/NKB/dynorphin A (KNDy) neurons by transfecting Kiss1 inside arcuate Tac3 neurons recovered folliculogenesis and luteinizing hormone (LH) pulses in female global Kiss1 knockout (KO) rats and that >90% conditional arcuate Kiss1 KO in newly generated Kiss1-floxed rats completely suppressed LH pulses. [Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors discuss the essential roles of microglia and innate immune signaling in the assembly and maintenance of a properly functioning nervous system. [Nature Reviews Immunology] |
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| Scientists explore the use of human-induced pluripotent stem cells (iPSCs) to study prion-like protein propagation in neurodegenerative diseases, discuss the advantages and limitations of this model, and present emerging technologies that, combined with the use of iPSC-based models, will provide powerful model systems to propel fundamental research forward. [Molecular Psychiatry] |
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| Alector, Inc. announced that the first participant has been dosed in INVOKE-2, a Phase II clinical study evaluating the efficacy and safety of AL002 in slowing disease progression in individuals with early Alzheimer’s disease. [Alector, Inc. (Globe Newswire, Inc.)] |
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| BioArctic AB announced that the European Patent Office has issued a decision to grant European patent EP 2 448 968 B1 for novel antibodies that could be developed into a treatment for Alzheimer’s disease. [BioArctic AB] |
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| February 3 – 5, 2021 Virtual |
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| University of Ottawa – Ottawa, Ontario, Canada |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Center of Advanced European Studies and Research – Bonn, Germany |
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| Center of Advanced European Studies and Research – Bonn, Germany |
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| IDG/McGovern Institute for Brain Research; Peking University – Beijing, China |
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