 | | Vol. 15.04 – 3 February, 2021 |
| |
|
|
| Using recordings from single cells in the human dorsomedial prefrontal cortex, investigators identified neurons that reliably encoded information about others’ beliefs across richly varying scenarios and that distinguished self- from other-belief-related representations.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists demonstrated the opposing metabolic effects of low-level and high-level mitochondrial ribosomal stress in hypothalamic proopiomelanocortin (POMC) neurons.
[Cell Metabolism] |
|
|
|
| Researchers identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification.
[Nature Neuroscience] |
|
|
|
| Investigators presented a versatile optogenetic toolbox of artificial multi-headed myosin motors that could move bidirectionally within long cellular extensions and allowed for the selective transport of GFP-tagged cargo with light.
[Nature Cell Biology] |
|
|
|
| The authors report that protein arginine methyltransferase (PRMT) 6 activity was required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells, a subpopulation in glioblastoma critical for malignancy.
[Molecular Cell] |
|
|
|
| Layered double hydroxide achieved significant performance in accelerating neural stem cell migration, neural differentiation, L-Ca22+ channel activation, and inducible action potential generation.
[ACS Nano] |
|
|
|
| Scientists showed that elevation of CXCL1 or CXCL2 facilitated myeloid cell migration and simultaneously disrupted CD8+ T cell accumulation at tumor sites, causing accelerated tumor progression.
[Science Advances] |
|
|
|
| investigators developed a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson’s disease.
[Science Advances] |
|
|
|
| The authors showed that lysophosphatidic acid (LPA), a multifunctional bioactive phospholipid, acted as a physiological extracellular factor to initiate cilia disassembly and promote neurogenesis.
[Nature Communications] |
|
|
|
| Investigators describe a time-course single-cell-transcriptomic analysis of developing human stem cell-derived oligodendrocyte-lineage-cells.
[Nature Communications] |
|
|
|
| Researchers provided an insight into the developing adrenal gland and introduced the Schwann cell precursor gene signature as being of interest for further research in understanding neuroblastoma phenotype.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| By combining electrophysiological and phosphoproteomic approaches, scientists showed that TWEAK acutely dampened basal synaptic transmission and plasticity through neuronal Fn14 and impacted the phosphorylation state of pre-and postsynaptic proteins in adult mouse hippocampal slices.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
|
| The authors summarize a large body of work using global and conditional mouse mutants to characterize the in vivo roles of sodium channels. They provide an overview of the neurological disorders associated with mutations of the human genes and examples of the effects of patient mutations on channel function.
[Nature Reviews Neuroscience] |
|
|
|
| Investigators deconstruct the RNA transport apparatus, exploring each constituent’s role in RNA localization and illuminating their unique contributions to neurodegeneration.
[Nature Neuroscience] |
|
|
|
|
|
| Sio Gene Therapies, Inc. announced that the first patient with infantile Tay-Sachs disease has been dosed in a Phase I/II trial evaluating AXO-AAV-GM2, investigational gene therapy for the treatment of GM2 gangliosidosis, also known as Tay-Sachs or Sandhoff disease.
[Sio Gene Therapies, Inc.] |
|
|
|
|
| February 11, 2021
Virtual |
|
|
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | Max Delbrück Center for Molecular Medicine in the Helmholtz Association – Berlin, Germany |
|
|
|
| | Baylor College of Medicine -Houston, Texas, United States |
|
|
|
| | Karolinska Institutet – Solna, Sweden |
|
|
|
| | Karolinska Institutet – Solna, Sweden |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
