 | | Vol. 15.07 – 24 February, 2021 |
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| By engineering human fetal neural stem cell cultures from distinct brain regions, investigators demonstrated that cell-intrinsic regional identity provided differential responsiveness to each mutant that mirrored the origins of pediatric high-grade gliomas.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed a human embryonic stem cell (hESC)-based model of H3.3G34R-mutant glioma that recapitulated the key features of the tumors with cell-type specificity to forebrain interneuronal progenitors but not hindbrain precursors.
[Cell Stem Cell] |
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| Researchers report that oxidized phosphatidylcholines (OxPCs) found in multiple sclerosis lesions were potent drivers of neurodegeneration. Cultured neurons and oligodendrocytes were killed by OxPCs, and this was ameliorated by microglia.
[Nature Neuroscience] |
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| Using single-cell RNA sequencing from white and gray matter separately, investigators identified white matter-associated microglia, which share parts of the disease-associated microglia gene signature and were characterized by activation of genes implicated in phagocytic activity and lipid metabolism.
[Neuron] |
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| Scientists performed snRNAseq on 482,472 nuclei from non-demented control brains and Alzheimer’s disease (AD) brains containing only amyloid-β plaques or both amyloid-β plaques and tau pathology. Within the microglia population, distinct expression profiles were identified of which two were AD pathology-associated.
[Acta Neuropathologica] |
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| To study the roles of DNAJC6 in Parkinson’s disease (PD) pathogenesis, the authors used human embryonic stem cells with CRISPR-Cas9-mediated gene editing. They showed that DNAJC6 mutations caused key PD pathologic features in human midbrain-like organoid.
[Science Advances] |
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| Researchers showed that the growth arrest-specific 7 (GAS7) gene, located at chromosome band 17p13.1, is preferentially deleted in high-risk MYCN-driven neuroblastoma.
[Cancer Research] |
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| The authors analyzed the role of the photoperiodic neuronal response and its relationship with clock genes, focusing on pars intercerebralis neurons.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Cleavage of the long 3′ untranslated region (3′ UTR) of Inositol Monophosphatase 1 (IMPA1) mediated by a protein complex containing the endonuclease argonaute 2 generated a translatable isoform that was necessary for maintaining the integrity of sympathetic neuron axons.
[Cell Reports] |
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| Scientists analyzed synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific sets of GABAergic neurons in S1.
[Cell Reports] |
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| Researchers showed that GBP5 was highly expressed in glioblastoma cell lines and in clinical samples, especially in the mesenchymal subtype.
[Cell Death & Disease] |
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| Investigators review recent findings addressing the reciprocal relationship in which neurons alter oligodendroglial form and oligodendrocytes conversely modulate neuronal function.
[Neuron] |
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| Florica Therapeutics, Inc. has been awarded a National Science Foundation Small Business Innovation Research grant for $255,678 to work on the Hypothalamus Stem Cell Exosomes for Treatment of COVID-19 project.
[Florica Therapeutics, Inc. (Businesswire, Inc)] |
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| The American Institute for Medical and Biological Engineering has elected to its College of Fellows Evan Snyder, professor and founding director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys Medical Discovery Institute.
[Sanford Burnham Prebys Medical Discovery Institute] |
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| March 29 – 30, 2021
Virtual |
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| | State University of New York College at Buffalo – Buffalo, New York, United States |
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| | Verge Genomics – South San Francisco, California, United States |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | Cleveland Clinic – Cleveland, Ohio, United States |
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