 | | Vol. 15.08 – 3 March, 2021 |
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| Researchers showed that the nuclear lamina protein lamin B1 was downregulated with age in mouse hippocampal neural stem cells, whereas protein levels of SUN-domain containing protein 1, previously implicated in Hutchinson-Gilford progeria syndrome, increased.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Analyses revealed that both pan-Sorting nexin-19 (SNX19) and pan-Arsenic methyltransferase (AS3MT) were more highly expressed in neurons than non-neurons in layers II/III and VI of the dorsolateral prefrontal cortex.
[Molecular Psychiatry] |
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| Loss of NPC1 triggered enhanced phagocytic uptake and impaired myelin turnover in microglia that precede neuronal death.
[Nature Communications] |
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| The authors report that exon junction complexes accumulated at basal bodies of mouse neural stem cells or retinal pigment epithelial cells and declined when these cells differentiated or resumed growth.
[Nature Communications] |
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| Researchers developed a cellular model of Bardet-Biedl Syndrome using induced pluripotent stem cell (iPSCs)-derived hypothalamic arcuate-like neurons.
[Journal of Clinical Investigation] |
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| Using CRISPR/Cas9‐based gene disruption of the epigenetic co‐repressor protein Trim28, scientists found a dynamic H3K9me3‐dependent regulation of endogenous retroviruses in proliferating neural progenitor cells, but not in adult neurons.
[EMBO Journal] |
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| Researchers investigated the molecular mechanisms underlying the antitumor effect of cannabidiol in preclinical models of human glioma.
[Autophagy] |
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| Investigators showed that loss of neuronal autophagy facilitated presynaptic neurotransmission by controlling the axonal endoplasmic reticulum and, thereby, axonal and synaptic calcium homeostasis.
[Autophagy] |
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| To determine whether temporal gene expression in neural progenitors correlates with neuron type specification, the authors performed a single-cell RNA sequencing analysis of the developing mouse neocortex.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Suppression of 40 genes using viral-driven short hairpin RNAs promoted retinal ganglion cell axon regeneration after optic nerve crush, and most were validated by separate CRISPR-Cas9 editing experiments.
[Cell Reports] |
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| Synaptotagmin-like 3-knockout caused an abnormal distribution of deep-layer neurons in brain organoids and reduced presynaptic neurotransmitter release in human embryonic stem cell-derived neurons.
[Cell Reports] |
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| Effects of drug combinations on cell viability, proliferation, apoptosis, and colony forming were assessed in a panel of neuroblastoma cell lines.
[Oncogene] |
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| Scientists describe how the immune system relays information to the nervous system and how cytokine signaling occurs in neurons.
[Nature Reviews Immunology] |
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| The authors review current knowledge of how levels of neurogenesis are regulated, discuss findings regarding survival and maturation of adult-born cells and describe how newborn neurons affect brain function.
[Nature Reviews Neuroscience] |
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| Investigators explore reactive microglial dysregulation of neural circuit structure and function following cancer therapy.
[Trends in Neurosciences] |
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| Orbus Therapeutics, Inc. announced a positive outcome of the pre-planned interim analysis for futility in its Phase III STELLAR clinical study of eflornithine in patients with recurrent anaplastic astrocytoma.
[Orbus Therapeutics, Inc.] |
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| BioXcel Therapeutics, Inc. announced an update to its BXCL501 dementia program, including clinical updates and the scheduling of its end of Phase II meeting with the FDA.
[BioXcel Therapeutics, Inc.] |
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| April 11 – 13, 2021
San Diego, California, United States |
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| | University of Maryland – College Park, Maryland, United States |
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| | Medical University of Vienna – Vienna, Austria |
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| | CyberCoders – San Diego, California, United States |
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| | State University of New York College at Buffalo – Buffalo, New York, United States |
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| | Verge Genomics – South San Francisco, California, United States |
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