 | | Vol. 15.14 – 14 April, 2021 |
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| By serially transplanting glioblastoma multiforme stem cells (GSCs) into immunocompetent hosts, scientists uncovered an acquired capability of GSCs to escape immune clearance by establishing an enhanced immunosuppressive tumor microenvironment.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers pinpointed multiple factors that disrupted neural stem cell (NSC) behavior in the adult hippocampus. Clonal tracing showed that NSCs exhibited asynchronous depletion by identifying short-term NSCs and long-term NSCs.
[Cell Stem Cell] |
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| Investigators showed that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures.
[Science Advances] |
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| The authors utilized an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the production of amyloid-beta peptides in hiPSC-derived neural cultures.
[Molecular Psychiatry] |
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| Researchers identified the white matter as a differentiative niche for glioblastomas with oligodendrocyte lineage competency.
[Nature Communications] |
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| Investigators demonstrated that neuronal α-Synuclein (α-Syn) inclusions consisted of α-Syn fibrils intermixed with membranous organelles, and illuminated the mechanism of aggregate seeding and cellular interaction.
[Nature Communications] |
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| Glioblastoma-associated microglia/macrophages secreted interleukin 11 activated STAT3-MYC signaling in glioblastoma cells. This signaling induced stem cell states that conferred enhanced tumorigenicity and resistance to the standard-of-care chemotherapy, temozolomide.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and p53 genomic binding sites. These sex-biased gene expression patterns were also evident in human glioblastoma stem cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors investigated the hypothesis that neural stem cells release and traffic functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells.
[PLoS Biology] |
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| Investigators report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
[Cell Death & Disease] |
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| Researchers established a library of cancer cell lines that overexpressed mutant proteins using the U87MG and patient-derived cell models lacking functional PTEN.
[Cell Death & Disease] |
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| Scientists provide a brief overview of the role of astrocytes in regulating synaptic transmission and neuronal function and discuss how cocaine influences these astrocyte-mediated mechanisms to induce persistent synaptic and circuit alterations that promote cocaine seeking and relapse.
[Molecular Psychiatry] |
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| The authors present both sides of the story with a particular emphasis on the beneficial properties of innate immune cells and how they can be targeted to have neuroprotective properties.
[Molecular Psychiatry] |
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| Investigators summarize the current knowledge about the cellular and physiological functions of WDR45 and highlight how genetic variants in its encoding gene may contribute to the pathophysiology of the associated diseases.
[Autophagy] |
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| Otsuka Pharmaceutical Co., Ltd and H. Lundbeck A/S has announced the decision to continue the recruitment of patients in the Phase III clinical trial of brexpiprazole in the treatment of agitation in patients with dementia of the Alzheimer’s type.
[Otsuka Pharmaceutical Co., Ltd] |
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| MedRhythms has announced the initiation of a multi-site clinical trial, in collaboration with Boston University, of its pipeline asset MR-005 in Parkinson’s disease as well as the expansion of the company’s pipeline into aging with the development of its Aging Scientific Advisory Board.
[MedRhythms (Cision US Inc.)] |
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| Treovir, LLC has announced that G207, an oncolytic HSV immunotherapy, was well tolerated with evidence of clinical effectiveness in a Phase I study of 12 pediatric patients with recurrent high-grade glioma.
[Treovir, LLC (Cision US Inc.)] |
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| May 19 – May 21, 2021
Virtual |
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| | Francis Crick Institute – London, England. United Kingdom |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Duke-NUS Medical School – Singapore, Singapore |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | NIH National Institute on Aging – Baltimore, Maryland, United States |
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