 | | Vol. 15.15 – 21 April, 2021 |
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| Investigators profiled the transcriptome of 43,261 cells derived from Rax+ hypothalamic neuroepithelium to map the developmental landscape of the mouse hypothalamus and trajectory of radial glial cells, intermediate progenitor cells, nascent neurons, and peptidergic neurons.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists revealed that the TAM system was an essential mediator of microglial recognition and engulfment of amyloid plaques and that TAM-driven microglial phagocytosis did not inhibit, but rather promoted dense-core plaque development.
[Nature Immunology] |
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| The authors showed that δ-secretase selectively cleaved UNC5C and escalated its proapoptotic activity, facilitating neurodegeneration in Alzheimer’s disease.
[Science Advances] |
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| Researchers report that neural progenitor cells and astrocytes differentiated from late-onset Alzheimer’s disease patient-derived induced pluripotent stem cells exhibited multiple inter-related bioenergetic alterations.
[Molecular Psychiatry] |
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| Using multiple genetic approaches, scientists showed that selective deletion of the PERK in mouse midbrain dopaminergic neurons resulted in multiple cognitive and motor phenotypes.
[Molecular Psychiatry] |
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| Based on the enzyme-mimicking properties, the constructed 2D vanadium carbide MXene nanoenzyme (MXenzyme) not only possessed high biocompatibility but also exhibited robust in vitro cytoprotection against oxidative stress.
[Nature Communications] |
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| Researchers showed that the type 1 integral membrane protein neuropilin-1 was expressed not on oligodendrocyte precursor cells but on amoeboid and activated microglia in white but not gray matter in an age- and activity-dependent manner.
[Nature Communications] |
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| The authors performed single-cell transcriptomics to define embryonic hypothalamic microglia heterogeneity and identified four microglial subsets, including a subpopulation adjacent to neural stem cells that were responsive to gestational cold stress.
[Developmental Cell] |
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| Investigators describe a mechanism by which depolarized neurons elevated the somatic ATP/ADP ratio in Drosophila glutamatergic neurons.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists investigated the role of forkhead box transcription factor 3a (FOXO3a) in regulating the sensitivity of glioma cells to temozolomide and its relationship with Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3)-mediated mitophagy.
[Acta Pharmacologica Sinica] |
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| Investigators explored the specific functions of M2 phenotype microglia-derived extracellular vesicles in ischemic brain injury progression.
[Laboratory Investigation] |
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| Both tumor suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Investigators performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
[Cell Death Discovery] |
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| The authors reiterate the merit of using the α-syn preformed fibril model as a tool to understand the physiological changes associated with Lewy bodies while highlighting the neuroprotective potential of harnessing endogenous brain-derived neurotrophic factor.
[npj Parkinson’s Disease] |
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| Scientists show how understanding differences in the stability of attractor network systems in different brain areas can help to provide a scientific basis for relating some mental disorders to the operation of the underlying brain systems.
[Translational Psychiatry] |
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| LEXEO Therapeutics announced that the FDA has granted Fast Track designation to LX1001, the company’s adeno-associated virus-mediated gene therapy program, for the potential treatment of apolipoprotein E4 associated Alzheimer’s disease.
[LEXEO Therapeutics] |
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| Retrotope announced that enrollment has been completed for its multicenter Phase II clinical trial evaluating RT001, the company’s lead development candidate, in patients with ALS or Lou Gehrig’s disease.
[Retrotope] |
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| May 25 – 27, 2021
Virtual |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Max Planck Institute – Nijmegen, Netherlands |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Boston Childrens Hospital – Boston, Massachusetts, Unted States |
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