Neural Cell News Volume 15.17 | May 05 2021

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    Neural Cell News by STEMCELL Technologies
    Vol. 15.17 – 5 May, 2021
    TOP STORY

    SynNotch-CAR
    T Cells Overcome Challenges of Specificity, Heterogeneity, and Persistence in Treating Glioblastoma

    Scientists developed synthetic notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma.
    [Science Translational Medicine]

    Full Article


    Stem Cell Conference Registration Award
    PUBLICATIONSRanked by the impact factor of the journal

    Optogenetic
    Pacing of Medial Septum Parvalbumin-Positive Cells Disrupts Temporal but Not Spatial Firing in Grid Cells

    Researchers showed that optogenetic activation of parvalbumin-positive cells in the medial septal area enabled selective pacing of local field potential oscillations in medial entorhinal cortex.
    [Science Advances]

    Full Article

    Co-occupancy
    Identifies Transcription Factor Co-operation for Axon Growth

    Scientists developed a bioinformatics pipeline, centered on transcription factors co-occupancy of regulatory DNA, and used it to predict factors that potentiate the effects of pro-regenerative Klf6 in vitro.
    [Nature Communications]

    Full Article

    EGFR
    Activates a TAZ-Driven Oncogenic Program in Glioblastoma

    In patient-derived glioblastoma neurospheres, EGF induced TAZ through EGFR-ERK and EGFR-STAT3 signaling, and the constitutively active EGFRvIII mutation caused EGF-independent hyperactivation of TAZ.
    [Cancer Research]

    Abstract

    Impaired
    Inhibitory GABAergic Synaptic Transmission and Transcription Studied in Single Neurons by Patch-Seq in Huntington’s Disease

    Investigators demonstrated that Patch-seq technology can be applied both to better understand molecular mechanisms underlying a complex neurological disease at the single-cell level and to provide a platform for screening for therapeutics for the disease.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Neuromodulator
    Release in Neurons Requires Two Functionally Redundant Calcium Sensors

    Researchers showed that in mouse hippocampal neurons, dense core vesicles fusion was strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    POU2F2
    Regulates Glycolytic Reprogramming and Glioblastoma Progression via PDPK1-Dependent Activation of PI3K/AKT/mTOR Pathway

    Researchers identified that the highly expressed POU Class Homeobox 2 (POU2F2) significantly correlated with poor prognosis of glioblastoma patients. POU2F2 promoted cell proliferation and regulated glycolytic reprogramming.
    [Cell Death & Disease]

    Full Article

    MicroRNA-138
    Suppresses Glioblastoma Proliferation through Downregulation of CD44

    Transient overexpression of miR-138 in glioblastoma cells inhibited cell proliferation, cell cycle, migration, and wound healing capability. The authors unveiled that miR-138 negatively regulated the expression of CD44 by directly binding to the 3′ UTR of CD44.
    [Scientific Reports]

    Full Article

    Novel
    Dopamine Receptor 3 Antagonists Inhibit the Growth of Primary and Temozolomide Resistant Glioblastoma Cells

    To improve treatment of glioblastoma, including those resistant to temozolomide , researchers explored the potential of targeting dopamine receptor signaling.
    [PLoS One]

    Full Article

    STEMCELL's Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells.
    REVIEWS

    Non-Neuronal
    Cells in Amyotrophic Lateral Sclerosis — From Pathogenesis to Biomarkers

    Scientists provide an overview of the diverse roles of non-neuronal cells in relation to the pathogenesis of ALS and the emerging potential of non-neuronal cell biomarkers to advance therapeutic development.
    [Nature Reviews Neurology]

    Abstract

    Little
    Cells of the Little Brain: Microglia in Cerebellar Development and Function

    The authors examine the roles microglia play in cerebellar function, development, and aging. The emerging findings on cerebellar microglia may also provide insights into disease processes involving cerebellar dysfunction.
    [Trends in Neurosciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    First US Ischemic Stroke Patients Treated with Rapid Medical’s Novel Clot Retriever

    The first patients in the United States have been treated with Rapid Medical’s FDA cleared TIGERTRIEVER™ revascularization device by Dr. Rishi Gutpa, Director of Neurocritcal Care at Wellstar Health System in Georgia. TIGERTRIEVER is the first adjustable stent retriever, enabling neuro interventionalists to better remove blood clots and restore blood flow to the brain following an ischemic event—a condition that devastates 800,000 Americans annually.
    [Rapic Medical, Inc. (Business Wire, Inc.)]

    Press Release
    FEATURED EVENT

    World Stem Cell Summit

    June 14 – 18, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Faculty Position-Developmental Neurobiology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States


    Oligonucleotide Biologist – Liver, Central Nervous System, and Eye

    Deep Genomics, Inc. – Toronto, Ontario, Canada

    Director – Cancer Research

    Cyprus Cancer Research Institute – Republic of Cyprus

    Postdoctoral Researcher – Modeling Gene Disruptions in Human Neurons

    Max Planck Institute – Nijmegen, Netherlands

    Assistant or Associate Professor – Neuro Immunoengineering

    University of British Columbia – Vancouver, British Columbia, Canada

    >
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