Neural Cell News Volume 15.18 | May 12 2021

May 12, 2022

Subject

Neural Cell News by STEMCELL Technologies

Vol. 15.18 – 12 May, 2021

TOP STORY

Neuronal
ApoE Upregulates MHC-I Expression to Drive Selective Neurodegeneration in Alzheimer’s Disease

Scientists sought potential drivers of the selective vulnerability using single-nucleus RNA sequencing and discovered that ApoE expression level was a substantial driver of neuronal variability.
[Nature Neuroscience]

Abstract

Explore scientific events this May with the Science Events Calendar.

PUBLICATIONSRanked by the impact factor of the journal

Integrating
Barcoded Neuroanatomy with Spatial Transcriptional Profiling Enables Identification of Gene Correlates of Projections

Researchers determined the expression of cadherins and cell-type markers in 29,933 cells and the projections of 3,164 cells in both the mouse motor cortex and auditory cortex.
[Nature Neuroscience]

Abstract

Cadherin-13
Is a Critical Regulator of GABAergic Modulation in Human Stem-Cell-Derived Neuronal Networks

Scientists identified functional network parameters that were most reliably affected by GABAergic modulation as such, and through alterations of excitation/inhibition balance by reduced expression of Cadherin – 13 in GABAergic neurons.
[Molecular Psychiatry]

Full Article

Loss
of Function Mutations in GEMIN5 Cause a Neurodevelopmental Disorder

Investigators have identified 30 affected individuals from 22 unrelated families presenting with developmental delay, hypotonia, and cerebellar ataxia harboring biallelic variants in the GEMIN5 gene.
[Nature Communications]

Full Article

RHOA
Signaling Defects Result in Impaired Axon Guidance in iPSC-Derived Neurons from Patients with Tuberous Sclerosis Complex

Scientists generated human induced pluripotent stem cell lines from a patient with Tuberous Sclerosis Complex and genetically engineered counterparts and isogenic controls. By differentiating hiPSCs, they showed that control neurons responded to canonical guidance cues as predicted.
[Nature Communications]

Full Article

A
Neural Basis for Brain Leptin Action on Reducing Type 1 Diabetic Hyperglycemia

Researchers showed that leptin receptor (LepR)-expressing neurons in arcuate (LepRArc) were selectively activated in type 1 diabetes.
[Nature Communications]

Full Article

The
Anesthetic Sevoflurane Induces Tau Trafficking from Neurons to Microglia

Scientists assessed mice and neurons treated with anesthetics sevoflurane and desflurane, and applied nanobeam-sensor technology, an ultrasensitive method, to measure tau/p-tau amounts.
[Nature Communications]

Full Article

Concurrent
Targeting of MAP3K3 and BRD4 by miR-3140-3p Overcomes Acquired Resistance to BET Inhibitors in Neuroblastoma Cells

Investigators demonstrated that miR-3140-3p suppressed tumor cell growth in MYCN-amplified neuroblastoma by downregulating MYCN and MYC through BRD4 suppression.
[Molecular Therapy-Nucleic Acids]

Abstract Graphical Abstract

Differential
Acute Impact of Therapeutically Effective and Overdose Concentrations of Lithium on Human Neuronal Single Cell and Network Function

Scientists described that human induced pluripotent stem cells-cortical neurons exposed to lithium showed an increased neuronal activity under all tested concentrations.
[Translational Psychiatry]

Full Article

Explore neural organoid technologies with this free wallchart from STEMCELL and Nature Neuroscience

REVIEWS

Glutamate
and Microglia Activation as a Driver of Dendritic Apoptosis: A Core Pathophysiological Mechanism to Understand Schizophrenia

The apoptotic loss of dendritic spines would be aggravated by microglia activation through a recently described signaling system from complement abnormalities and proteins of the MHC, thus implicating the immune system in schizophrenia.
[Translational Psychiatry]

Full Article

INDUSTRY AND POLICY NEWS

NOXXON Announces Data Safety Monitoring Board Validates NOX-A12 Highest Dose in Phase I/II Brain Cancer Trial

NOXXON Pharma, Inc. announced that an independent Data Safety Monitoring Board has confirmed that the highest dose of NOX-A12 in combination with radiotherapy in the ongoing Phase I/II study in patients with brain cancer is safe and that the trial should continue as planned.
[NOXXON Pharma, Inc.]

Press Release

FEATURED EVENT

Neuronal
ApoE Upregulates MHC-I Expression to Drive Selective Neurodegeneration in Alzheimer’s Disease

Integrating
Barcoded Neuroanatomy with Spatial Transcriptional Profiling Enables Identification of Gene Correlates of Projections

Cadherin-13
Is a Critical Regulator of GABAergic Modulation in Human Stem-Cell-Derived Neuronal Networks

Loss
of Function Mutations in GEMIN5 Cause a Neurodevelopmental Disorder

RHOA
Signaling Defects Result in Impaired Axon Guidance in iPSC-Derived Neurons from Patients with Tuberous Sclerosis Complex

A
Neural Basis for Brain Leptin Action on Reducing Type 1 Diabetic Hyperglycemia

The
Anesthetic Sevoflurane Induces Tau Trafficking from Neurons to Microglia

Concurrent
Targeting of MAP3K3 and BRD4 by miR-3140-3p Overcomes Acquired Resistance to BET Inhibitors in Neuroblastoma Cells

Differential
Acute Impact of Therapeutically Effective and Overdose Concentrations of Lithium on Human Neuronal Single Cell and Network Function

Glutamate
and Microglia Activation as a Driver of Dendritic Apoptosis: A Core Pathophysiological Mechanism to Understand Schizophrenia

NOXXON Announces Data Safety Monitoring Board Validates NOX-A12 Highest Dose in Phase I/II Brain Cancer Trial

Technologies
for Neuroengineering

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Postdoctoral Fellow – Neurosciences

Faculty Position – Developmental Neurobiology

Oligonucleotide Biologist – Liver, Central Nervous System, and Eye

Director – Cancer Research

Assistant or Associate Professor – Neuro Immunoengineering

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