Neural Cell News Volume 15.19 | May 19 2021

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    Neural Cell News by STEMCELL Technologies
    Vol. 15.19 – 19 May, 2021
    TOP STORY

    Nociceptive Sensory Neurons Promote CD8 T Cell Responses to HSV-1 Infection

    Researchers showed that Nav1.8+ sensory neurons, which were involved in pain perception, control the magnitude of CD8 T cell priming and expansion in HSV-1-infected mice.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    MeCP2 Controls Neural Stem Cell Fate Specification through miR-199a-Mediated Inhibition of BMP-Smad Signaling

    Investigators showed that the MeCP2/miR-199a axis regulated neural stem/precursor cell differentiation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Nuclear Isoform of FGF13 Regulates Post-Natal Neurogenesis in the Hippocampus through an Epigenomic Mechanism

    Scientists found that FGF13A, the nuclear isoform of FGF13, was involved in the maintenance of neural stem cells and the suppression of neuronal differentiation during post-natal hippocampal development.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Leptin Increases GABAergic Synaptogenesis through the Rho Guanine Exchange Factor β-PIX in Developing Hippocampal Neurons

    Using molecular and electrophysiological techniques, researchers found that leptin increased the surface localization of GABAA receptors and the number of functional GABAergic synapses in hippocampal cultures from male and female rat pups.
    [Science Signaling]

    Full Article

    Novel Fragile X Syndrome 2D and 3D Brain Models Based on Human Isogenic FMRP-KO iPSCs

    Scientists generated 2D and 3D in vitro human FXS model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines.
    [Cell Death & Disease]

    Full Article

    β-Arrestin 2 Stimulates Degradation of HIF-1α and Modulates Tumor Progression of Glioblastoma

    Investigators demonstrated that β-arrestin 2 (Arrb2) interacted with HIF-1α and stimulated ubiquitin-mediated 26S proteasomal degradation of HIF-1α by recruiting PHD2 and pVHL.
    [Cell Death & Disease]

    Full Article

    CD109-GP130 Interaction Drives Glioblastoma Stem Cell Plasticity and Chemoresistance through STAT3 Activity

    Researchers reported CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of glioma stem cells and as a mediator of chemoresistance.
    [JCI Insight]

    Full Article

    Neuron and Astrocyte Aggregation and Sorting in Three-Dimensional Neuronal Constructs

    Linear, adhered rat and human 3D neuronal-astrocyte cultures were developed to enable the study of aggregation and sorting of these cells. An in silico model of the contraction, clustering, and cell sorting in the 3D cultures was also developed.
    [Communications Biology]

    Full Article

    RNAi and Chemogenetic Reporter Co-Regulation in Primate Striatal Interneurons

    Researchers modulated cholinergic signaling of striatal interneurons by shRNAmir and paired it with hM4Di_CFP, a chemogenetic receptor that could function as an in vivo and in situ reporter.
    [Gene Therapy]

    Full Article

    Hyperbaric Oxygen Promotes Not Only Glioblastoma Proliferation but Also Chemosensitization by Inhibiting HIF1α/HIF2α-Sox2

    Scientists performed a series of studies and determined that the expression of HIF1α, HIF2α and Sox2 was decreased after hyperbaric oxygen (HBO) and that HBO promoted glioblastoma cell proliferation through cell cycle progression, albeit with a decrease in stemness, thus contributing to chemosensitization via the inhibition of HIF1α/HIF2α-Sox2.
    [Cell Death Discovery]

    Full Article

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    REVIEWS

    Cortical Disinhibitory Circuits: Cell Types, Connectivity and Function

    The authors highlight multiple layers of disinhibition across cortical circuits that regulate behavior and serve to maintain an excitation/inhibition balance.
    [Trends in Neurosciences]

    Abstract

    INDUSTRY AND POLICY NEWS

    Tellus Therapeutics Secures Seed Financing to Develop the First Treatment for Newborns with White Matter Brain Injury

    Tellus Therapeutics, Inc., announced a seed investment from Xontogeny, LLC to advance their lead program through IND-enabling work.
    [Tellus Therapeutics, Inc. (Business Wire, Inc.)]

    Press Release

    The Clinic by Cleveland Clinic Launches New Multidisciplinary Virtual Second Opinion Program for Brain and Prostate Cancer

    The Clinic by Cleveland Clinicâ„¢, announced that its virtual second opinion solution, available to health plans, employers and consumers, will include multidisciplinary case analysis
    [The Clinic by Cleveland Clinicâ„¢ (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    Cell-Mediated Therapies for Infectious Disease Summit

    Jul 20 – 22, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Neuroscience

    Icahn School of Medicine – Mount Sinai, New York, United States

    Postdoctoral Fellow – Neurosciences

    Lerner Research Institute – Cleveland, Ohio, United States

    Faculty Position – Developmental Neurobiology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Oligonucleotide Biologist – Liver, Central Nervous System, and Eye

    Deep Genomics, Inc. – Toronto, Ontario, Canada

    Assistant or Associate Professor – Neuro Immunoengineering

    University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

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