| Vol. 15.19 – 19 May, 2021 |
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| Researchers showed that Nav1.8+ sensory neurons, which were involved in pain perception, control the magnitude of CD8 T cell priming and expansion in HSV-1-infected mice. [Nature Communications] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the MeCP2/miR-199a axis regulated neural stem/precursor cell differentiation. [Cell Reports] |
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| Scientists found that FGF13A, the nuclear isoform of FGF13, was involved in the maintenance of neural stem cells and the suppression of neuronal differentiation during post-natal hippocampal development. [Cell Reports] |
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| Using molecular and electrophysiological techniques, researchers found that leptin increased the surface localization of GABAA receptors and the number of functional GABAergic synapses in hippocampal cultures from male and female rat pups. [Science Signaling] |
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| Scientists generated 2D and 3D in vitro human FXS model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines. [Cell Death & Disease] |
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| Investigators demonstrated that β-arrestin 2 (Arrb2) interacted with HIF-1α and stimulated ubiquitin-mediated 26S proteasomal degradation of HIF-1α by recruiting PHD2 and pVHL. [Cell Death & Disease] |
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| Researchers reported CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of glioma stem cells and as a mediator of chemoresistance. [JCI Insight] |
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| Linear, adhered rat and human 3D neuronal-astrocyte cultures were developed to enable the study of aggregation and sorting of these cells. An in silico model of the contraction, clustering, and cell sorting in the 3D cultures was also developed. [Communications Biology] |
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| Researchers modulated cholinergic signaling of striatal interneurons by shRNAmir and paired it with hM4Di_CFP, a chemogenetic receptor that could function as an in vivo and in situ reporter. [Gene Therapy] |
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| Scientists performed a series of studies and determined that the expression of HIF1α, HIF2α and Sox2 was decreased after hyperbaric oxygen (HBO) and that HBO promoted glioblastoma cell proliferation through cell cycle progression, albeit with a decrease in stemness, thus contributing to chemosensitization via the inhibition of HIF1α/HIF2α-Sox2. [Cell Death Discovery] |
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| The authors highlight multiple layers of disinhibition across cortical circuits that regulate behavior and serve to maintain an excitation/inhibition balance. [Trends in Neurosciences] |
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| Tellus Therapeutics, Inc., announced a seed investment from Xontogeny, LLC to advance their lead program through IND-enabling work. [Tellus Therapeutics, Inc. (Business Wire, Inc.)] |
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| The Clinic by Cleveland Clinicâ„¢, announced that its virtual second opinion solution, available to health plans, employers and consumers, will include multidisciplinary case analysis [The Clinic by Cleveland Clinicâ„¢ (Business Wire, Inc.)] |
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| Jul 20 – 22, 2021 Virtual |
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| Icahn School of Medicine – Mount Sinai, New York, United States |
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| Lerner Research Institute – Cleveland, Ohio, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Deep Genomics, Inc. – Toronto, Ontario, Canada |
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| University of British Columbia – Vancouver, British Columbia, Canada |
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