Neural Cell News Volume 15.20 | May 26 2021

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    Neural Cell News by STEMCELL Technologies
    Vol. 15.20 – 26 May, 2021
    TOP STORY

    Cell-Type-Specific
    Effects of Genetic Variation on Chromatin Accessibility during Human Neuronal Differentiation

    Researchers identified significant genetic effects on 988/1,839 neuron/progenitor regulatory elements, with highly cell-type and temporally specific effects.
    [Nature Neuroscience]

    Abstract

    Watch this webinar to learn about the role of microglia in mechanisms of immune activation to Alzheimer's pathology.
    PUBLICATIONSRanked by the impact factor of the journal

    Adult
    Neural Stem Cells Have Latent Inflammatory Potential That Is Kept Suppressed by Tcf4 to Facilitate Adult Neurogenesis

    The authors demonstrated that the adult hippocampal neural progenitors harbored an inflammatory potential that is proactively suppressed by transcription factor 4 (Tcf4).
    [Science Advances]

    Full Article

    Non-Productive
    Angiogenesis Disassembles Aß Plaque-Associated Blood Vessels

    Researchers showed that Aß plaque-associated non-productive angiogenesis locally disassembled blood vessels, leaving behind vascular scars, and that microglial phagocytosis contributed to the local loss of endothelial cells.
    [Nature Communications]

    Full Article

    MiR-124
    Synergism with ELAVL3 Enhances Target Gene Expression to Promote Neuronal Maturity

    Scientists identified targets of miR-9/9*-124 as reprogramming cells activated the neuronal program and revealed the role of miR-124 that directly promoted the expression of its target genes associated with neuronal development and function.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Metalloproteinase
    1 Downregulation in Neurofibromatosis 1: Therapeutic Potential of Antimalarial Hydroxychloroquine and Chloroquine

    Researchers analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous neurofibroma and found excessive expression of collagen and reduced expression of MMP1.
    [Cell Death & Disease]

    Full Article

    Ndufs4
    Ablation Decreases Synaptophysin Expression in Hippocampus

    Investigators silenced Ndufs4 in Neuro-2a cells and they observed shorter neurite lengths with decreased expression of synaptophysin.
    [Scientific Reports]

    Full Article

    A
    Potential Role for Somatostatin Signaling in Regulating Retinal Neurogenesis

    By analyzing retinal explants treated with selective ligands that target these receptors, researchers found that Sstr2-dependent somatostatin signaling induces a modest, dose-dependent inhibition of photoreceptor generation, while correspondingly increasing the relative fraction of primary progenitor cells.
    [Scientific Reports]

    Full Article

    Isolation
    of Genetically Manipulated Neural Progenitors and Immature Neurons from Embryonic Mouse Neocortex by FACS

    Researchers described a protocol for investigation of the effects of genetic manipulation on neural development through direct isolation of neural progenitors and neurons from the mouse embryonic neocortex by fluorescence-activated cell sorting.
    [Star Protocol]

    Full Article

    Tryptophan
    Metabolism Drives Dynamic Immunosuppressive Myeloid States in IDH-Mutant Gliomas

    Scientists defined myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrated their strict control by the tumor genotype: in isocitrate dehydrogenase (IDH)-mutant tumors, differentiation of infiltrating myeloid cells was blocked, resulting in an immature phenotype.
    [Nature Cancer]

    Full Article

    Scientific resources to support your organoids research. Learn More!
    REVIEWS

    Present
    State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons

    The authors discuss the potential of prostaglandins as candidates for the development of new therapeutic drugs for motor neuron diseases.
    [Cellular and Molecular Neurobiology]

    Abstract

    Blood-Brain
    Barrier Dysfunction as a Potential Therapeutic Target for Neurodegenerative Disorders

    Scientists review a potential role of the major cellular components of the blood-brain barrier (BBB), with a focus on the contribution of BBB disruption, in neurodegenerative disease progression.
    [Archives of Pharmacal Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    VistaGen Therapeutics Initiates PALISADE Phase III Trial of PH94B in Social Anxiety Disorder

    VistaGen Therapeutics Inc. announced the initiation of its PALISADE Phase III clinical program with the PALISADE-1 Phase III trial, a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of PH94B for the acute treatment of anxiety in adults with Social Anxiety Disorder.
    [VistaGen Therapeutics Inc. (Globenews Wire, Inc.)]

    Press Release

    BrainsWay Announces First of Its Kind Positive Coverage Policy by Centene for the Treatment of OCD Utilizing Deep TMS™

    BrainsWay Ltd. announced that Centene Corporation has published a positive coverage policy for Deep Transcranial Magnetic Stimulation treatment of obsessive-compulsive disorder using the BrainsWay Deep TMS™ system.
    [BrainsWay Ltd. (Globenews Wire, Inc.)]

    Press Release

    FEATURED EVENT

    NeuroImmune
    Interactions in Health and Disease

    7 – 9 June, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Group Leader – Cellular Neuroscience

    Ulm University – Ulm, Germany

    Postdoctoral Fellow – Neuroscience

    Icahn School of Medicine – Mount Sinai, New York, United States

    Postdoctoral Fellow – Neurosciences

    Lerner Research Institute – Cleveland, Ohio, United States

    Faculty Position-Developmental Neurobiology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States


    Oligonucleotide Biologist – Liver, Central Nervous System, and Eye

    Deep Genomics, Inc. – Toronto, Ontario, Canada

    >
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