 | | Vol. 15.21 – 2 June, 2021 |
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| By performing unbiased transcriptional profiling of DMV cholinergic neurons, the authors discovered seven molecularly distinct subtypes of motor neurons.
[Neuron] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the molecular effects of lithium (Li), valproate, and lamotrigine treatment in induced pluripotent stem cell (iPSC)-derived neural precursor cells generated from three healthy controls, three affective disorder Li responsive patients and three Li non-treated patients after six hours and one week of exposure.
[Molecular Psychiatry] |
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| Investigators evaluated elongating multi-lineage organized over a 40 day period, applying immunofluorescence of multi-lineage and functional biomarkers, including day 16 single-cell RNA-Seq, and evaluation of ectodermal and non-ectodermal neural crest cells.
[Nature Communications] |
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| Scientists showed that deletion of prohibitin 1 in Schwann cells minimally perturbed development, but later triggered a severe demyelinating peripheral neuropathy.
[Nature Communications] |
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| Researchers described a multicenter effort to test the generality of the pivotal observation, using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors compared gene expression of growth factors in normal human nerves to malignant peripheral nerve sheath tumors (MPNST) and normal human Schwann cells to MPNST cell lines.
[Oncogene] |
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| The upregulated gonadotropin-releasing hormone (GnRH) expression in GT1-7 GnRH neuronal cells induced by the 5-HT receptor 1A (HTR1A) antagonist WAY-100635 maleate was observed in vitro.
[Molecular Therapy-Nucleic Acids] |
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| Scientists used isogenic human induced pluripotent stem cells (iPSCs) with and without PARK2 knockout to investigate the effect of parkin loss of function by comparative metabolomics supplemented with ultrastructural and functional analyses.
[Stem Cell Reports] |
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| Investigators found that elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells.
[Cancer Gene Therapy] |
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| The authors aimed to understand how extracellular cellular communication network factor 1 altered the glioblastomas intracellular state to confer oncolytic virus resistance.
[Scientific Reports] |
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| Researchers investigated whether a generation of adenovirus vectors that possessed a suicide gene allowed for detection of undifferentiated human pluripotent stem cells (iPSCs) in preparations of human iPSC-derived neural progenitor cells.
[Scientific Reports] |
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| The authors summarize the various roles of astrocytes in recruiting immune cells to lesion sites, engendering the inflammatory loop, and inflicting tissue damage.
[International Journal of Molecular Sciences] |
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| Investigators summarize the anti-tumor effects of miR-124. They then discuss the functions of miR-124 with that of its original role in neurons.
[International Journal of Molecular Sciences] |
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| Brain Cancer Canada turned awareness into action by emphatically supporting groundbreaking research into brain cancer treatment. The charity has made $100,000 available to Dr. Sheila Singh and her research group at McMaster University to target recurrent glioblastomas with generous support from sponsors.
[Brain Cancer Canada] |
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| June 21 – 22, 2021
Virtual |
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| | Burke Medical Research Institute – White Plains, New York, United States |
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| | Western University of Health Sciences – Lebanon, Oregon, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Ulm University – Ulm, Germany |
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| | Icahn School of Medicine – Mount Sinai, New York, United States |
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