Neural Cell News Volume 15.22 | Jun 9 2021

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    Neural Cell News by STEMCELL Technologies
    Vol. 15.22 – 9 June, 2021
    TOP STORY

    Epigenomic Landscape and 3D Genome Structure in Pediatric High-Grade Glioma

    To investigate whether H3K27M was associated with distinct chromatin structure that altered transcription regulation, investigators generated the first high-resolution genome structure maps of pediatric high-grade gliomas cell lines and tumor tissue.
    [Science Advances]

    Full Article

    Survey results on the insights and hurdles of CRISPR genome editing.
    PUBLICATIONSRanked by the impact factor of the journal

    Synergistic Immunotherapy of Glioblastoma by Dual Targeting of IL-6 and CD40

    Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.
    [Nature Communications]

    Full Article

    Nucleocytoplasmic Transport of the RNA-Binding Protein CELF2 Regulates Neural Stem Cell Fates

    In self-renewing neural stem/progenitor cells, CELF2 resided in the cytoplasm, where it repressed mRNAs encoding cell fate regulators and neurodevelopmental disorder-related factors.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Replicative Senescence Dictates the Emergence of Disease-Associated Microglia and Contributes to Aβ Pathology

    Researchers aimed to understand the long-term impact of the early and prolonged microglial proliferation observed in Alzheimer’s disease, hypothesizing that extensive and repeated cycling would engender a distinct transcriptional and phenotypic trajectory.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Small Molecule 1a Reduces FMRpolyG-Mediated Toxicity in In Vitro and In Vivo Models for FMR1 Premutation

    Scientists presented for the first time primary hippocampal neurons derived from the ubiquitous inducible mouse model used as a screening tool for targeted interventions.
    [Human Molecular Genetics]

    Abstract

    Convergent NMDA Receptor—Pannexin1 Signaling Pathways Regulate the Interaction of CaMKII with Connexin-36

    To explain the molecular mechanism of how Cx36 modified plasticity at gap junctions, researchers investigated the roles of ionotropic N-methyl-D-aspartate receptors and pannexin1 channels in regulating Cx36 binding to Ca2+/calmodulin-dependent protein kinase II (CaMKII).
    [Communications Biology]

    Full Article

    H2S Protects Hippocampal Neurons against Hypoxia-Reoxygenation Injury by Promoting RhoA Phosphorylation at Ser188

    Reserachers investigated the target and mechanism of H2S in inhibition of RhoA/ROCK. GST-RhoAwild and GST-RhoAS188A proteins were constructed and expressed, and were used for phosphorylation assay in vitro.
    [Cell Death Discovery]

    Full Article

    Differentiation of Human Adult-Derived Stem Cells towards a Neural Lineage Involves a Dedifferentiation Event Prior to Differentiation to Neural Phenotypes

    Scientists demonstrated that hPDLSCs, hBMSCs and hDPSCs could directly differentiate into neuron-like cells without passing through a mitotic stage and that they shrunk dramatically and changed their morphology to that of neuron-like cells through active neurite extension.
    [Scientific Reports]

    Full Article

    Isorhapontigenin Ameliorates Cerebral Ischemia/Reperfusion Injury via Modulating Kinase Cε/Nrf2/HO-1 Signaling Pathway

    Focal cerebral ischemia-reperfusion injury model and primary cortical neurons were established an oxygen-glucose deprivation injury model. Neuronal cell viability was determined by MTT assay. Western blot analysis was determined for protein expression.
    [Brain and Behavior]

    Full Article

    Request your free copy of the 'Building Three-Dimensional Human Brain Organoids' Wallchart
    REVIEWS

    Molecular Mechanisms of Cell Death in Neurological Diseases

    The authors discuss the interplay between distinct cell death signaling cascades and disease pathogenesis and describe pharmacological agents targeting key players in the cell death signaling pathways that have progressed through to clinical trials.
    [Cell Death & Differentiation]

    Full Article

    INDUSTRY AND POLICY NEWS

    Bayer to Advance Two First-of-Its-Kind Investigational Cell and Gene Therapies for Parkinson’s Disease

    Bayer AG announced that BlueRock Therapeutics successfully administered the first dose of its investigational pluripotent stem cell-derived dopaminergic neurons, named DA01, to a Parkinson’s disease patient in their open-label Phase I clinical safety and tolerability study.
    [Bayer AG (BusinessWire, Inc.)]

    Press Release

    IGC Completes Cohort II of Its Phase I THC-Based Clinical Trial on Alzheimer’s Patients

    India Globalization Capital, Inc. (IGC) announced that it has completed Cohort II of its Phase I clinical trial on IGC’s tetrahydrocannabinol-based investigational new drug, IGC-AD1, intended to alleviate the symptoms of individuals suffering from Alzheimer’s disease.
    [India Globalization Capital, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Epithelial Stem Cells and Niches

    June 5 – 10, 2022
    Ventura, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Biopsychology

    Technische Universität Dresden – Dresden, Germany

    Postdoctoral Scholar – Neuroscience and Metabolism

    Oregon Health and Science University – Portland, Oregon, United States

    Postdoctoral Fellow – Neuroscience

    Burke Medical Research Institute – White Plains, New York, United States

    Postdoctoral Position – Environmental Chemicals in Neurodegenerative Disease Using Human Stem Cell Models

    Western University of Health Sciences – Lebanon, Oregon, United States

    Group Leader – Cellular Neuroscience

    Ulm University – Ulm, Germany

    > See All Jobs

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