Neural Cell News Volume 15.23 | Jun 16 2021

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    2021-06-16 | NCN 15.23


    Neural Cell News by STEMCELL Technologies
    Vol. 15.23 – 16 June, 2021
    TOP STORY

    Omega-3 Polyunsaturated Fatty Acids Protect against Inflammation through Production of LOX and CYP450 Lipid Mediators: Relevance for Major Depression and for Human Hippocampal Neurogenesis

    Investigators used the human hippocampal progenitor cell line HPC0A07/03C, and pre-treated cells with either eicosapentaenoic acid and docosahexaenoic acid, followed by interleukin 1 beta (IL1β), IL6 and interferon-alpha.
    [Molecular Psychiatry]

    Full ArticlePress Release


    Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation
    PUBLICATIONSRanked by the impact factor of the journal

    P32-Specific CAR T Cells with Dual Antitumor and Antiangiogenic Therapeutic Potential in Gliomas

    Scientists generated p32 chimeric antigen receptors (CAR) T cells and found them to recognize and specifically eliminate p32 expressing glioma cells and tumor derived endothelial cells in vitro and to control tumor growth in orthotopic syngeneic and xenograft mouse models.
    [Nature Communications]

    Full Article

    Mapping Chromatin Accessibility and Active Regulatory Elements Reveals Pathological Mechanisms in Human Gliomas

    Researchers performed whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples to unravel epigenetic dysfunctions driving gliomagenesis.
    [Nature Communications]

    Full Article

    Radiation-Induced YAP Activation Confers Glioma Radioresistance via Promoting FGF2 Transcription and DNA Damage Repair

    Researchers found that high yes-associated protein (YAP) expression was associated with poor prognosis in malignant glioma patients undergoing radiotherapy.
    [Oncogene]

    Full Article

    G-Protein-Coupled Receptor GPR17 Inhibits Glioma Development by Increasing Polycomb Repressive Complex 1-Mediated ROS Production

    Overexpressing GPR17 inhibited glioma cell proliferation and induced apoptosis by raising ROS levels. GPR17-overexpressing glioma cells were less tumorigenic in the brain than in control cells.
    [Cell Death & Disease]

    Full Article

    ISL1 Promoted Tumorigenesis and EMT via Aurora Kinase A-Induced Activation of PI3K/AKT Signaling Pathway in Neuroblastoma

    Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 was preferentially upregulated in NB tissues compared with normal tissues.
    [Cell Death & Disease]

    Full Article

    The Enzyme L-Isoaspartyl (D-Aspartyl) Methyltransferase Promotes Migration and Invasion in Human U-87 MG and U-251 MG Glioblastoma Cell Lines

    Scientists investigated protein L-isoaspartyl (D-aspartyl) methyltransferase role in U-87 MG cell viability, adhesion, migration, invasion, and colony formation and in the reorganization of the actin and tubulin cytoskeleton.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Genome-Wide CRISPR Screen Identifies Protein Pathways Modulating Tau Protein Levels in Neurons

    Researchers reported a genome-wide CRISPR screen to identify modulators of endogenous tau protein for the first time. Primary screens performed in SH-SY5Y cells, identified positive and negative regulators of tau protein levels.
    [Communications Biology]

    Full Article

    Neuroprotective Effect of Selumetinib on Acrolein-Induced Neurotoxicity

    The neuroprotective effect of selumetinib on acrolein-induced neurotoxicity was investigated in vitro using primary cultured cortical neurons.
    [Scientific Reports]

    Full Article

    Protective Role of ABCA1 in Ischemic Preconditioning Is Mediated by Downregulation of miR-33-5p and miR-135-5p

    Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.
    [Scientific Reports]

    Full Article


    Her 'mini-brains' creation was unexpected. Her protocol was groundbreaking. Watch Madeline Lancaster's webinar.
    REVIEWS

    Amyloid-β: A Potential Link between Epilepsy and Cognitive Decline

    The authors review evidence that amyloid-β (Aβ) forms part of a shared pathway between epilepsy and cognitive decline, particularly in the context of Alzheimer’s disease.
    [Nature Reviews Neurology]

    Abstract

    Neuroadaptations and TGF-β Signaling: Emerging Role in Models of Neuropsychiatric Disorders

    Investigators focus on what is currently known about the TGF-β signaling in the central nervous system in mediating cellular and behavioral plasticity related to neuropsychiatric manifestations.
    [Molecular Psychiatry]

    Abstract

    Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity

    Scientists provide a comprehensive review of the most relevant findings of molecular and pathophysiological mechanisms by which hypothalamic astrocytes might be involved in the pathogenesis of obesity.
    [International Journal of Molecular Sciences]

    Full Article

    INDUSTRY AND POLICY NEWS

    Mark Hughes Foundation Makes $7.5 Million Commitment to Accelerating Brain Cancer Research

    Mark Hughes Foundation has announced a $7.5 million five-year philanthropic commitment to the University of Newcastle.
    [University of Newcastle]

    Press Release

    FEATURED EVENT

    European Meeting on Glial Cells and Diseases

    July 5 – 9, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship Position – Post-Stroke Recovery

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    Research Associate – Biopsychology

    Technische Universität Dresden – Dresden, Germany

    PhD Student – Wnt Signaling

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Scholar – Neuroscience and Metabolism

    Oregon Health and Science University – Portland, Oregon, United States

    Group Leader – Cellular Neuroscience

    Ulm University – Ulm, Germany

    > See All Jobs

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