| Vol. 15.23 – 16 June, 2021 |
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| Investigators used the human hippocampal progenitor cell line HPC0A07/03C, and pre-treated cells with either eicosapentaenoic acid and docosahexaenoic acid, followed by interleukin 1 beta (IL1β), IL6 and interferon-alpha. [Molecular Psychiatry] |
| | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists generated p32 chimeric antigen receptors (CAR) T cells and found them to recognize and specifically eliminate p32 expressing glioma cells and tumor derived endothelial cells in vitro and to control tumor growth in orthotopic syngeneic and xenograft mouse models. [Nature Communications] |
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| Researchers performed whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples to unravel epigenetic dysfunctions driving gliomagenesis. [Nature Communications] |
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| Researchers found that high yes-associated protein (YAP) expression was associated with poor prognosis in malignant glioma patients undergoing radiotherapy. [Oncogene] |
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| Overexpressing GPR17 inhibited glioma cell proliferation and induced apoptosis by raising ROS levels. GPR17-overexpressing glioma cells were less tumorigenic in the brain than in control cells. [Cell Death & Disease] |
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| Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 was preferentially upregulated in NB tissues compared with normal tissues. [Cell Death & Disease] |
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| Scientists investigated protein L-isoaspartyl (D-aspartyl) methyltransferase role in U-87 MG cell viability, adhesion, migration, invasion, and colony formation and in the reorganization of the actin and tubulin cytoskeleton. [Biomedicine & Pharmacotherapy] |
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| Researchers reported a genome-wide CRISPR screen to identify modulators of endogenous tau protein for the first time. Primary screens performed in SH-SY5Y cells, identified positive and negative regulators of tau protein levels. [Communications Biology] |
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| The neuroprotective effect of selumetinib on acrolein-induced neurotoxicity was investigated in vitro using primary cultured cortical neurons. [Scientific Reports] |
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| Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation. [Scientific Reports] |
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| The authors review evidence that amyloid-β (Aβ) forms part of a shared pathway between epilepsy and cognitive decline, particularly in the context of Alzheimer’s disease. [Nature Reviews Neurology] |
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| Investigators focus on what is currently known about the TGF-β signaling in the central nervous system in mediating cellular and behavioral plasticity related to neuropsychiatric manifestations. [Molecular Psychiatry] |
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| Scientists provide a comprehensive review of the most relevant findings of molecular and pathophysiological mechanisms by which hypothalamic astrocytes might be involved in the pathogenesis of obesity. [International Journal of Molecular Sciences] |
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| Mark Hughes Foundation has announced a $7.5 million five-year philanthropic commitment to the University of Newcastle. [University of Newcastle] |
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| The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| Technische Universität Dresden – Dresden, Germany |
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| German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| Oregon Health and Science University – Portland, Oregon, United States |
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| Ulm University – Ulm, Germany |
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