| Vol. 15.24 – 23 June, 2021 |
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| Scientists discovered COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the influence of genotypes at TMEM106B and hexanucleotide repeat expansions in C9orf72 on global TDP-43 pathology and regional distribution of TDP-43 pathology in 899 postmortem cases from a spectrum of neurodegenerative diseases. [Acta Neuropathologica] |
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| Investigators utilized human induced pluripotent stem cells to generate reproducible organoids that recapitulated dorsal forebrain development including early corticogenesis. [Molecular Psychiatry] |
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| The authors discovered that prohibitin specifically regulated mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance. [Nature Communications] |
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| Scientists identified and validated the presence of hematopoietic stem and progenitor cells within glioblastoma tissues. [Nature Communications] |
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| Researchers showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro. [Journal of Clinical Investigation] |
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| To investigate the cis-elements controlling NOVA2-regulation of circRNA biogenesis, investigators generated a backsplicing reporter based on the Efnb2 gene. [Nucleic Acids Research] |
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| The authors explored the apparent link between LAP2β and nuclear membrane (NM) ruptures in nuclear lamin–deficient neurons and fibroblasts, and they tested whether manipulating LAP2β expression levels would alter NM rupture frequency. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists demonstrated that ATF6β was highly expressed in the hippocampus of the brain, and specifically regulated the expression of calreticulin, a molecular chaperone in the endoplasmic reticulum with a high Ca2+-binding capacity. [Scientific Reports] |
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| Researchers developed and applied such assays to measure the levels of leucine-rich repeat kinase 2 as well as the phosphorylation of LRRK2 itself or one of its substrates, Rab10. [Scientific Reports] |
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| The authors discuss some of the key technologies, including circuit modulation with optogenetics, in vivo imaging with miniaturized single-photon microscopy and fiber photometry, and how the application of these technologies has garnered novel insights into the neurobiology of addiction. [Molecular Psychiatry] |
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| The European Commission has approved Aubagio® for the treatment of pediatric patients 10 to 17 years of age with relapsing-remitting multiple sclerosis. [GlobeNewsWire, Inc.] |
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| Alzheon, Inc., announced that it has achieved enrollment target of 80 patients for its Phase II biomarker study of ALZ-801 in Early Alzheimer’s disease patients, who carry either one or two copies of the ε4 allele of apolipoprotein E gene. [Alzheon, Inc.] |
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| July 27 – 29, 2021 Virtual |
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| Baylor College of Medicine – Houston, Texas, United States |
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| The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| Technische Universität Dresden – Dresden, Germany |
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| Oregon Health and Science University – Portland, Oregon, United States |
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| Ulm University – Ulm, Germany |
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