Neural Cell News Volume 15.24 | Jun 23 2021

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    2021-06-23 | NCN 15.24


    Neural Cell News by STEMCELL Technologies
    Vol. 15.24 – 23 June, 2021
    TOP STORY

    Dysregulation of Brain and Choroid Plexus Cell Types in Severe COVID-19

    Scientists discovered COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease.
    [Nature]

    Abstract

    Virtual Conference Exhibition: Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    TMEM106B Modifies TDP-43 Pathology in Human ALS Brain and Cell-Based Models of TDP-43 Proteinopathy

    Researchers investigated the influence of genotypes at TMEM106B and hexanucleotide repeat expansions in C9orf72 on global TDP-43 pathology and regional distribution of TDP-43 pathology in 899 postmortem cases from a spectrum of neurodegenerative diseases.
    [Acta Neuropathologica]

    Abstract

    Neurodevelopmental Signatures of Narcotic and Neuropsychiatric Risk Factors in 3D Human-Derived Forebrain Organoids

    Investigators utilized human induced pluripotent stem cells to generate reproducible organoids that recapitulated dorsal forebrain development including early corticogenesis.
    [Molecular Psychiatry]

    Full Article

    Suppression of Mitochondrial ROS by Prohibitin Drives Glioblastoma Progression and Therapeutic Resistance

    The authors discovered that prohibitin specifically regulated mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance.
    [Nature Communications]

    Full Article

    Tumor-Associated Hematopoietic Stem and Progenitor Cells Positively Linked to Glioblastoma Progression

    Scientists identified and validated the presence of hematopoietic stem and progenitor cells within glioblastoma tissues.
    [Nature Communications]

    Full Article

    Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

    Researchers showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    NOVA2 Regulates Neural circRNA Biogenesis

    To investigate the cis-elements controlling NOVA2-regulation of circRNA biogenesis, investigators generated a backsplicing reporter based on the Efnb2 gene.
    [Nucleic Acids Research]

    Full Article

    Increased Expression of LAP2β Eliminates Nuclear Membrane Ruptures in Nuclear Lamin–Deficient Neurons and Fibroblasts

    The authors explored the apparent link between LAP2β and nuclear membrane (NM) ruptures in nuclear lamin–deficient neurons and fibroblasts, and they tested whether manipulating LAP2β expression levels would alter NM rupture frequency.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    The ATF6β-Calreticulin Axis Promotes Neuronal Survival under Endoplasmic Reticulum Stress and Excitotoxicity

    Scientists demonstrated that ATF6β was highly expressed in the hippocampus of the brain, and specifically regulated the expression of calreticulin, a molecular chaperone in the endoplasmic reticulum with a high Ca2+-binding capacity.
    [Scientific Reports]

    Full Article

    Understanding LRRK2 Kinase Activity in Preclinical Models and Human Subjects through Quantitative Analysis of LRRK2 and pT73 Rab10

    Researchers developed and applied such assays to measure the levels of leucine-rich repeat kinase 2 as well as the phosphorylation of LRRK2 itself or one of its substrates, Rab10.
    [Scientific Reports]

    Full Article

    STEMCELL's Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells.
    REVIEWS

    Application of Optogenetics and In Vivo Imaging Approaches for Elucidating the Neurobiology of Addiction

    The authors discuss some of the key technologies, including circuit modulation with optogenetics, in vivo imaging with miniaturized single-photon microscopy and fiber photometry, and how the application of these technologies has garnered novel insights into the neurobiology of addiction.
    [Molecular Psychiatry]

    Full Article

    INDUSTRY AND POLICY NEWS

    European Commission Approves Aubagio® (Teriflunomide) as the First Oral MS Therapy for First-Line Treatment of Children and Adolescents Living with Relapsing-Remitting Multiple Sclerosis

    The European Commission has approved Aubagio® for the treatment of pediatric patients 10 to 17 years of age with relapsing-remitting multiple sclerosis.
    [GlobeNewsWire, Inc.]

    Press Release

    Alzheon Completes Patient Enrollment in Phase II Biomarker Trial of ALZ-801 Oral Tablet in APOE4 Carriers with Alzheimer’s Disease

    Alzheon, Inc., announced that it has achieved enrollment target of 80 patients for its Phase II biomarker study of ALZ-801 in Early Alzheimer’s disease patients, who carry either one or two copies of the ε4 allele of apolipoprotein E gene.
    [Alzheon, Inc.]

    Press Release

    FEATURED EVENT

    GammaDelta T Therapies Summit

    July 27 – 29, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Associate – Electrophysiology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowship Position – Post-Stroke Recovery

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    Research Associate – Biopsychology

    Technische Universität Dresden – Dresden, Germany

    Postdoctoral Scholar – Neuroscience and Metabolism

    Oregon Health and Science University – Portland, Oregon, United States

    Group Leader – Cellular Neuroscience

    Ulm University – Ulm, Germany

    > See All Jobs

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