Neural Cell News Volume 15.26 | Jul 07 2021

    By
    Justin.choi
    -
    0
    66






    2021-07-07 | NCN 15.26


    Neural Cell News by STEMCELL Technologies
    Vol. 15.26 – 7 July, 2021
    TOP STORY

    GABA-Receptive Microglia Selectively Sculpt Developing Inhibitory Circuits

    Investigators showed that GABA-receptive microglia selectively interacted with inhibitory cortical synapses during a critical window of mouse postnatal development.
    [Cell]

    Abstract| Graphical Abstract

    Webinar: The Promise of Organoid Medicine
    PUBLICATIONSRanked by the impact factor of the journal

    Long Noncoding RNA BS-DRL1 Modulates the DNA Damage Response and Genome Stability by Interacting with HMGB1 in Neurons

    Researchers reported and characterized a long noncoding RNA, termed Brain Specific DNA-damage Related lncRNA1 (BS-DRL1), in the central nervous system.
    [Nature Communications]

    Full Article

    α-TubK40me3 Is Required for Neuronal Polarization and Migration by Promoting Microtubule Formation

    Scientists reported that tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) was required for neuronal polarization and migration by promoting microtubule formation.
    [Nature Communications]

    Full Article

    VLM Catecholaminergic Neurons Control Tumor Growth by Regulating CD8+ T Cells

    Researchers reported that ventrolateral medulla (VLM) catecholaminergic neurons in the mouse brain were activated in tumor-bearing mice and the activity of these neurons significantly altered tumor growth in multiple syngeneic and spontaneous mouse tumor models.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Cell-Intrinsic Glial Pathology Is Conserved across Human and Murine Models of Huntington’s Disease

    The authors investigated mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in glial pathobiology across species and models.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Patient-Derived iPSC-Cerebral Organoid Modeling of the 17q11.2 Microdeletion Syndrome Establishes CRLF3 as a Critical Regulator of Neurogenesis

    Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in (neurofibromatosis type 1) NF1-total gene deletion hCOs.
    [Cell Reports]

    Full ArticleGraphical Abstract

    SKP-SCs Transplantation Alleviates 6-OHDA-Induced Dopaminergic Neuronal Injury by Modulating Autophagy

    Scientists investigated the effects of skin precursor cell-derived Schwann cells (SKP-SCs) directly cocultured with 6-OHDA-injured dopaminergic neurons in vitro and of SKP-SCs transplanted into the brains of 6-OHDA-induced Parkinson’s disease mice in vivo.
    [Cell Death & Disease]

    Full Article

    Protective Effects of Carbonic Anhydrase Inhibition in Brain Ischaemia In Vitro and In Vivo Models

    A new generation of carbonic anhydrase inhibitors and acetazolamide were investigated in two models of brain ischaemia: in rat hippocampal acute slices exposed to severe oxygen, glucose deprivation and in an in vivo model of focal cerebral ischaemia induced by permanent occlusion of the middle cerebral artery in the rat.
    [Journal of Enzyme inhibition and Medicinal Chemistry]

    Full Article

    Cytotoxic Effects and Tolerability of Gemcitabine and Axitinib in a Xenograft Model for C-Myc Amplified Medulloblastoma

    Using a c-myc amplified human medulloblastoma cell line, researchers performed an in-vitro-drug screen with single and combinatorial drugs that were either already clinically approved or agents in the advanced stage of clinical development.
    [Scientific Reports]

    Full Article

    Webinar: Organoids as Models for Human Disease
    REVIEWS

    Translational Evidence for Lithium-Induced Brain Plasticity and Neuroprotection in the Treatment of Neuropsychiatric Disorders

    The authors focus on neural adaptations that may underlie psychostimulant-induced psychotic development and to dissect, through the sensitization process, which features are shared in bipolar disorder and other psychiatric disorders, including schizophrenia.
    [Translational Psychiatry]

    Full Article

    INDUSTRY AND POLICY NEWS

    Neurolief Announces Exclusive Licensing Agreement with NeuroFront for Development and Commercialization of Relivion® in Greater China and South Korea

    Neurolief, Inc. and NeuroFront, Inc. jointly announced an exclusive licensing agreement for NeuroFront to develop and commercialize Relivion®, non-invasive medical devices for the treatment of migraine and depression, in Greater China and South Korea.
    [Neurolief, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    GammaDelta T Therapies Summit

    July 27 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    PhD/Postdoctoral Position – Astrocytes in Cortical Plasticity

    Flanders Institute for Biotechnology – Leuven, Belgium

    Faculty Position – Computational Neuroscience

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    Research Associate – Electrophysiology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowship Position – Post-Stroke Recovery

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    Research Associate – Biopsychology

    Technische Universität Dresden – Dresden, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Neural Cell News Twitter

    Brought to you by