Neural Cell News Volume 15.27 | Jul 14 2021

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    2021-07-14 | NCN 15.27


    Neural Cell News by STEMCELL Technologies
    Vol. 15.27 – 14 July, 2021
    TOP STORY

    Astrocytic Interleukin-3 Programs Microglia and Limits Alzheimer’s Disease

    Astrocytes produced IL-3, which elicited transcriptional, morphological, and functional programming of microglia to endow them with an acute immune response program, enhanced motility, and the capacity to cluster and clear aggregates of Aβ and tau.
    [Nature]

    Abstract

    Free Wallchart: Dynamic Modeling in Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    A Human Three-Dimensional Neural-Perivascular ‘Assembloid’ Promotes Astrocytic Development and Enables Modeling of SARS-CoV-2 Neuropathology

    Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 infection points. Scientists showed that pericyte-like cells, when integrated into a cortical organoid, were capable of infection with authentic SARS-CoV-2.
    [Nature Medicine]

    Full Article

    Generation of Caudal-Type Serotonin Neurons and Hindbrain-Fate Organoids from hPSCs

    Researchers proposed a novel strategy to generate hindbrain serotonin (5-HT) neurons from human pluripotent stem cells (PSCs), which involved the formation of ventral-type neural progenitor cells and stimulation of the hindbrain 5-HT neural development.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Pericytes Augment Glioblastoma Cell Resistance to Temozolomide through CCL5-CCR5 Paracrine Signaling

    Investigators uncovered that pericytes potentiated DNA damage repair in glioblastoma cells residing in the perivascular niche, which induced temozolomide chemoresistance.
    [Cell Research]

    Full Article

    Homozygous MTAP Deletion in Primary Human Glioblastoma Is Not Associated with Elevation of Methylthioadenosine

    Using comprehensive metabolomic profiling, scientists showed that methylthioadenosine (MTA) secreted by methylthioadenosine phosphorylaseMTAP-deleted cells in vitro resulted in high levels of extracellular MTA.
    [Nature Communications]

    Full Article

    Prokineticin-2 Prevents Neuronal Cell Deaths in a Model of Traumatic Brain Injury

    Researchers explored the regulatory role of prokineticin-2 in neuronal ferroptosis in vitro and in vivo.
    [Nature Communications]

    Full Article

    Extracellular Domain Shedding of the ALK Receptor Mediates Neuroblastoma Cell Migration

    Investigators mapped the cleavage site to Asn654-Leu655 and demonstrated that cleavage inhibition of wild-type anaplastic lymphoma kinase significantly impeded neuroblastoma cell migration with subsequent prolongation of survival in mouse models.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Levo-Tetrahydropalmatine Inhibits α4β2 Nicotinic Receptor Response to Nicotine in Cultured SH-EP1 Cells

    The targets and mechanisms of l-Tetrahydropalmatine ( l-THP)-caused anti-nicotine effects were largely unknown. Scientists addressed this question by elucidating the effects of l-THP on human neuronal nicotinic acetylcholine receptors using patch-clamp recordings.
    [Acta Pharmacologica Sinica]

    Abstract

    Activating Transcription Factor 4 Mediates Adaptation of Human Glioblastoma Cells to Hypoxia and Temozolomide

    Researchers hypothesized that activating transcription factor 4 was essential for the adaptation of human glioblastoma cells to the conditions of the tumor microenvironment and contributed to therapy resistance against chemotherapy.
    [Scientific Reports]

    Full Article

    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    REVIEWS

    Astrocyte-Neuron Signaling in the Mesolimbic Dopamine System: The Hidden Stars of Dopamine Signaling

    The authors examine evidence revealing that astrocytes respond to dopamine and modulate information processing in the primary brain regions implicated in the mesolimbic dopamine system.
    [Neuropharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    FDA Grants Orphan Drug Designation for Pridopidine for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

    Prilenia Therapeutics B.V., announced that the US FDA has granted Orphan Drug Designation for pridopidine for the treatment of ALS.
    [Prilenia Therapeutics B.V.]

    Press Release

    FEATURED EVENT

    11th World Congress on Alternatives and Animal Use in the Life Sciences

    August 23 – September 2, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Tumorigenesis in Melanoma and Glioblastoma

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    PhD/Postdoctoral Position – Astrocytes in Cortical Plasticity

    Flanders Institute for Biotechnology – Leuven, Belgium

    Faculty Position – Computational Neuroscience

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    Research Associate – Electrophysiology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowship Position – Post-Stroke Recovery

    The University of Texas Health Science Center at Houston – Houston, Texas, United States

    > See All Jobs

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