| Vol. 15.27 – 14 July, 2021 |
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| Astrocytes produced IL-3, which elicited transcriptional, morphological, and functional programming of microglia to endow them with an acute immune response program, enhanced motility, and the capacity to cluster and clear aggregates of Aβ and tau. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 infection points. Scientists showed that pericyte-like cells, when integrated into a cortical organoid, were capable of infection with authentic SARS-CoV-2. [Nature Medicine] |
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| Researchers proposed a novel strategy to generate hindbrain serotonin (5-HT) neurons from human pluripotent stem cells (PSCs), which involved the formation of ventral-type neural progenitor cells and stimulation of the hindbrain 5-HT neural development. [Stem Cell Reports] |
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| Investigators uncovered that pericytes potentiated DNA damage repair in glioblastoma cells residing in the perivascular niche, which induced temozolomide chemoresistance. [Cell Research] |
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| Using comprehensive metabolomic profiling, scientists showed that methylthioadenosine (MTA) secreted by methylthioadenosine phosphorylaseMTAP-deleted cells in vitro resulted in high levels of extracellular MTA. [Nature Communications] |
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| Researchers explored the regulatory role of prokineticin-2 in neuronal ferroptosis in vitro and in vivo. [Nature Communications] |
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| Investigators mapped the cleavage site to Asn654-Leu655 and demonstrated that cleavage inhibition of wild-type anaplastic lymphoma kinase significantly impeded neuroblastoma cell migration with subsequent prolongation of survival in mouse models. [Cell Reports] |
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| The targets and mechanisms of l-Tetrahydropalmatine ( l-THP)-caused anti-nicotine effects were largely unknown. Scientists addressed this question by elucidating the effects of l-THP on human neuronal nicotinic acetylcholine receptors using patch-clamp recordings. [Acta Pharmacologica Sinica] |
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| Researchers hypothesized that activating transcription factor 4 was essential for the adaptation of human glioblastoma cells to the conditions of the tumor microenvironment and contributed to therapy resistance against chemotherapy. [Scientific Reports] |
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| The authors examine evidence revealing that astrocytes respond to dopamine and modulate information processing in the primary brain regions implicated in the mesolimbic dopamine system. [Neuropharmacology] |
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| Prilenia Therapeutics B.V., announced that the US FDA has granted Orphan Drug Designation for pridopidine for the treatment of ALS. [Prilenia Therapeutics B.V.] |
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| August 23 – September 2, 2021 Virtual |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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| Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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