 | | Vol. 15.30 – 4 August, 2021 |
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| Investigators tested whether following immunization with a “cocktail” of 4 NMDAR1 peptides, induction of a spatially and temporally defined sterile encephalitis by diphtheria toxin-mediated ablation of pyramidal neurons would modify/aggravate the ensuing phenotype.
[Molecular Psychiatry] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Brain-derived neurotrophic factor (BDNF) is essential for adult synaptic plasticity and its pathway is associated with major depression and posttraumatic stress disorder. Researchers found that stress-enhanced matrix metalloproteinase 9 (MMP9) secretion increased the cleavage of proBDNF to its mature form mBDNF.
[Nature Communications] |
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| In neurons, Amyloid-β peptide (Aβ) accumulates in endo-lysosomal vesicles at low pH. Scientists showed that the rate of AβO assembly was accelerated 8,000-fold upon pH reduction from extracellular to endo-lysosomal pH, at the expense of amyloid fibril formation.
[Nature Communications] |
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| Researchers studied the effects of the balance between inhibitory and excitatory spontaneous neurotransmission on brain-derived neurotrophic factor (BDNF) regulation and synaptic plasticity.
[Cell Reports] |
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| Researchers showed that human cortical neurons, derived from human pluripotent stem cells in 2D cultures or in cortical organoids, developed the typical hallmarks of senescent cells when maintained in vitro for prolonged periods of time, and that moderated upregulation or repression of endogenous Klotho expression in cortical organoids inhibited and accelerateed senescence, respectively.
[npj Aging and Mechanisms of Disease] |
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| The authors showed that α-synuclein preformed fibrils induced pathogenic activation of human midbrain astrocytes, marked by inflammatory transcriptional responses, downregulation of phagocytic function, and conferral of neurotoxic activity.
[Cell Death & Disease] |
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| Investigators provided clear evidence for the role of casein kinase 2 in the control of activity-driven BACE1 expression in cultured primary neurons, organotypic brain slices, and murine Alzheimer’s disease models.
[Cell Death & Disease] |
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| Researchers characterized N-[(1R,2R)-2-{3–5-oxo-5H,6H,7H-pyrrolopyridin-6-yl}cyclohexyl]-2,2,3,3,3-pentafluoropropanamide (T-518), a novel, potent, highly selective histone deacetylase 6 inhibitor with clinically favorable pharmacodynamics.
[Scientific Reports] |
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| The authors investigated the maturation stages and electrophysiological properties of HTR2A-positive neurons induced from hiPSCs and constructed an HTR2A promoter-specific reporter lentivirus to label the neurons.
[Scientific Reports] |
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| Scientists discuss the immunostimulatory and immunosuppressive roles of interleukin-10 (IL-10) in the glioblastoma tumor microenvironment while considering IL-10-targeted treatment strategies.
[British Journal of Cancer] |
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| Calidi Biotherapeutics, Inc., announced that it has executed a license agreement with Northwestern University for the exclusive commercialization rights to the IND and data generated from Northwestern’s Phase I clinical trial treating brain tumor patients with an engineered oncolytic adenovirus delivered by neural stem cells.
[Calidi Biotherapeutics, Inc.] |
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| NeuroPace, Inc., announced the broad launch of its nSight Platform, an online portal that helps physicians provide more personalized, data-driven epilepsy care by enabling them to remotely review patient progress, discover actionable insights, and track their clinic’s overall patient outcomes.
[NeuroPace, Inc.] |
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| September 5 – 8, 2021
Exeter, England, United Kingdom |
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| MSH Medical School Hamburg – Hamburg, Germany |
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| | German Cancer Research Center – Heidelberg, Germany |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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