 | | Vol. 15.31 – 11 August, 2021 |
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| Scientists demonstrated two engineering elements to improve human brain organoid culture, including a human brain extracellular matrix to provide brain-specific cues and a microfluidic device with periodic flow to improve the survival and reduce the variability of organoids.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In vitro studies demonstrated that IFP35 and NMI were released by multiple cells. IFP35 and NMI subsequently triggered nuclear factor kappa B–dependent activation of microglia via the TLR4 pathway.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that slowing the activation of K+ current could increase the Na+ influx rate, and the effect of minimizing the overlap between Na+ and K+ currents on spike propagation resilience depended on complex interactions among diameter, myelination, and the Na/K pump density.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators used single-cell transcriptomics to dissect the cell states that emerge during neurogenin 2 (NGN2) overexpression across a time course from pluripotency to neuron functional maturation.
[Stem Cell Reports] |
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| Researchers carried out research to discover a novel alternative drug targeting the oncogenic NFAT signaling pathway for glioblastoma multiforme therapy.
[Acta Pharmacologica Sinica] |
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| The authors showed that interaction with tumor microenvironment elements, mainly activated monocytes through IL-6 secretion, and the extracellular matrix protein fibronectin, induced the Stat3 transcriptional pathway and upregulated ODZ1 which resulted in glioblastoma cell migration.
[Scientific Reports] |
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| Scientists observed that during normal cerebellar development, phosphorylated CREB was selectively expressed in differentiating cerebellar granule neuron progenitor cells.
[Scientific Reports] |
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| Researchers investigated the effects of Orengedokuto on inflammatory molecule induction in BV-2 microglial cells using real-time RT-PCR and ELISA.
[Heliyon] |
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| Scientists identified a microRNA that altered related components of the transport machinery to affect brain-derived neurotrophic factor retrograde signaling deficits in Alzheimer’s disease.
[nan] |
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| Scientists discuss possible disruptions to axon growth inhibitor signaling by lipid raft-localized receptors, as well as other yet unclear neuronal survival signaling process enhanced by cholesterol lowering or depletion.
[Neural Regeneration Research] |
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| BioVie Inc. announced that the company has enrolled the first patient into the NM101 Phase III clinical study testing NE3107 for the treatment of Alzheimer’s Disease.
[BioVie, Inc. (GlobeNewswire, Inc.)] |
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| September 22 – 25, 2021
Virtual |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| MSH Medical School Hamburg – Hamburg, Germany |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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