Neural Cell News Volume 15.32 | Aug 18 2021

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    2021-08-18 | NCN 15.32


    Neural Cell News by STEMCELL Technologies
    Vol. 15.32 – 18 August, 2021
    TOP STORY

    Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain

    Targeted sequencing of genes implicated in brain tumors in 418 samples derived from 110 individuals of varying ages, without tumor diagnoses, detected oncogenic somatic single-nucleotide variants in 5.4% of the brains, including IDH1 R132H.
    [Cancer Discovery]

    Abstract

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Brain Organoids Assemble Functionally Integrated Bilateral Optic Vesicles

    Using induced pluripotent stem cell-derived human brain organoids, researchers simplified the complexities and demonstrated formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    The Acute Phase Protein Lactoferrin Is a Key Feature of Alzheimer’s Disease and Predictor of Aβ Burden through Induction of APP Amyloidogenic Processing

    In vitro studies showed that an interaction between amyloid precursor protein (APP) and the iron-bound form of lactoferrin secreted from activated microglia diverted neuronal APP endocytosis from the canonical clathrin-dependent pathway to one requiring ADP ribosylation factor 6 trafficking.
    [Molecular Psychiatry]

    Full Article

    Astrocyte-Derived Neurons Provide Excitatory Input to the Adult Striatal Circuitry

    Researchers showed that most striatal astrocyte-derived neurons were confined to the anterior medial striatum, did not express established striatal neuronal markers, and exhibited dendritic spines, which were atypical for striatal interneurons.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    The Angiopoietin-Tie2 Pathway Regulates Purkinje Cell Dendritic Morphogenesis in a Cell-Autonomous Manner

    Researchers showed that in the developing cerebellum Tie2 expression was not restricted to blood vessels, but it is also present in Purkinjee cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Astrocyte-Derived TNF and Glutamate Critically Modulate Microglia Activation by Methamphetamine

    Scientists investigated the mechanisms underlying the aberrant activation of microglia elicited by methamphetamine (meth) in the adult mouse brain. They found that binge meth exposure caused microgliosis and disrupted risk assessment behavior both of which required astrocyte-to-microglia crosstalk.
    [Neuropsychopharmacology]

    Abstract

    Neuronal Chemokine-Like-Factor 1 (CKLF1) Up-Regulation Promotes M1 Polarization of Microglia in Rat Brain after Stroke

    Researchers showed that CKLF1 was significantly up-regulated in cultured rat cortical neurons subjected to oxygen-glucose deprivation/reoxygenation injury, but not in cultured rat microglia, astrocytes and oligodendrocytes.
    [Acta Pharmacologica Sinica]

    Full Article

    Intratumor Heterogeneity in MicroRNAs Expression Regulates Glioblastoma Metabolism

    Scientists revealed significant alterations in miRNA expression across three glioblastoma tumor regions: the core, rim, and invasive margin.
    [Scientific Reports]

    Full Article

    Targeting PUS7 Suppresses tRNA Pseudouridylation and Glioblastoma Tumorigenesis

    Investigators identified chemical inhibitors for PUS7 and showed that these compounds prevented pseudouridine synthase 7 (PUS7)-mediated pseudouridine modification, suppressed tumorigenesis and extended the life span of tumor-bearing mice.
    [Nature Cancer]

    Abstract

    Integrating Flexible Electronics for Pulsed Electric Field Delivery in a Vascularized 3D Glioblastoma Model

    Scientists showed with fluorescence widefield and multiphoton microscopy that pulsed electric fields induced vasoconstriction of blood vessels and evoked calcium signals in vascularized glioblastoma spheroids stably expressing a genetically encoded fluorescence reporter.
    [npj Flexible Electronics]

    Full Article


    Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.
    REVIEWS

    Foraging with the Frontal Cortex: A Cross-Species Evaluation of Reward-Guided Behavior

    The authors argue that translating findings from rodents to non-human primates requires an appreciation of both the niche in which each animal forages as well as the similarities in frontal cortex anatomy and function.
    [Neuropsychopharmacology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Feinstein Institutes Receives $1.3M NIH Bioelectronic Medicine Grant to Study Neuro-Immune Signaling

    The Feinstein Institutes for Medical Research, has been awarded a multi-year $1.3 million grant from the National Institutes of Health to study how immune signals are transmitted to the brain through the vagus nerve.

    [The Feinstein Institutes for Medical Research]

    Press Release

    FEATURED EVENT

    Genome Engineering and Synthetic Biology

    September 22 – 24, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – In Vitro Electrophysiology

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Research Fellow – Neurology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Researcher – Neuroimmunology of Brain Repair

    MSH Medical School Hamburg – Hamburg, Germany

    Postdoctoral Researcher – Electrophysiology of Neural Circuits with Gene Therapy

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Researcher – Tumorigenesis in Melanoma and Glioblastoma

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    > See All Jobs

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