| Vol. 15.35 – 8 September, 2021 |
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| Scientists defined ‘microglia inflamed in multiple sclerosis (MS)’ and ‘astrocytes inflamed in MS’, glial phenotypes that demonstrated neurodegenerative programming. [Nature] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of autism spectrum disorder with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical development. [Nature Communications] |
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| Scientists identified nodes of Ranvier as a direct site of interaction between microglia and axons, in both mouse and human tissues. [Nature Communications] |
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| Researchers showed that genetic and pharmacological aurora kinase A inhibition elicited metabolic reprogramming mediated by inhibition of MYC targets and concomitant activation of Peroxisome Proliferator Activated Receptor Alpha signaling. [Nature Communications] |
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| Through a genome-wide small RNA sequencing, researchers identified several tRNA-derived fragments and piwi-interacting RNA species were enriched in glutamate-induced neuronal necrosis in rat primary neuron cultures, and this enrichment was dependent on the H3K4 trimethylation increase. [Cell Death & Disease] |
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| A polydimethylsiloxane-based device that achieves directional connectivity between micro 3D cultures was demonstrated. The device consisted of through-holes for micro three-dimensional clusters of cortical cells connected by microtrenches for axon and dendrite guidance. [Microsystems & Nanoengineering] |
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| Using both human induced pluripotent stem cells and mouse models, researchers found that FUS-ALS causative mutations affected the activity of two relevant RNA-binding protein with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP. [Communications Biology] |
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| Researchers established an in vitro cellular model using neurons differentiated from Down syndrome patient-derived induced pluripotent stem cells (iPSCs) and isogenic euploid iPSCs. [Scientific Reports] |
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| Investigators studied functional parameters of synaptic vesicle recycling in hippocampal cultures from male and female rats, which were a standard model system for many laboratories. [Scientific Reports] |
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| Scientists investigated the effect of Apolipoprotein E (ApoE4) on autophagy in the human brains of ApoE4 carriers. [Scientific Reports] |
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| The authors provide an overview of microglia regulation of synaptic plasticity and learning and memory, and discuss the possibility of microglia manipulation as a therapeutic to ameliorate cognitive deficits associated with aging, neurocognitive disorder, and mental disorders. [Neural Regeneration Research] |
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| GNT Pharma Inc. reported that the Korea Ministry of Food and Drug Safety has approved the Investigational New Drug Application for a phase III study of nelonemdaz for acute ischemic stroke patients. [GNT Pharma Inc. (BusinessWire, Inc.)] |
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| October 25 – 26, 2021 Virtual |
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| Emory University – Atlanta, Georgia, United States |
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| University of Maryland, College Park – College Park, Maryland, United States |
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| Eisai Inc. – Woodcliff Lake, New Jersey, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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