Neural Cell News Volume 15.35 | Sep 8 2021

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    2021-09-08 | NCN 15.35


    Neural Cell News by STEMCELL Technologies
    Vol. 15.35 – 8 September, 2021
    TOP STORY

    A Lymphocyte–Microglia–Astrocyte Axis in Chronic Active Multiple Sclerosis

    Scientists defined ‘microglia inflamed in multiple sclerosis (MS)’ and ‘astrocytes inflamed in MS’, glial phenotypes that demonstrated neurodegenerative programming.
    [Nature]

    Abstract

    Join the New Horizons in Alzheimer's Disease hybrid conference!
    PUBLICATIONSRanked by the impact factor of the journal

    Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder

    Investigators utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of autism spectrum disorder with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical development.
    [Nature Communications]

    Full Article

    Microglia-Neuron Interaction at Nodes of Ranvier Depends on Neuronal Activity through Potassium Release and Contributes to Remyelination

    Scientists identified nodes of Ranvier as a direct site of interaction between microglia and axons, in both mouse and human tissues.
    [Nature Communications]

    Full Article

    Aurora Kinase a Inhibition Reverses the Warburg Effect and Elicits Unique Metabolic Vulnerabilities in Glioblastoma

    Researchers showed that genetic and pharmacological aurora kinase A inhibition elicited metabolic reprogramming mediated by inhibition of MYC targets and concomitant activation of Peroxisome Proliferator Activated Receptor Alpha signaling.
    [Nature Communications]

    Full Article

    Increased Expression of Fragmented tRNA Promoted Neuronal Necrosis

    Through a genome-wide small RNA sequencing, researchers identified several tRNA-derived fragments and piwi-interacting RNA species were enriched in glutamate-induced neuronal necrosis in rat primary neuron cultures, and this enrichment was dependent on the H3K4 trimethylation increase.
    [Cell Death & Disease]

    Full Article

    Microdevice for Directional Axodendritic Connectivity between Micro 3D Neuronal Cultures

    A polydimethylsiloxane-based device that achieves directional connectivity between micro 3D cultures was demonstrated. The device consisted of through-holes for micro three-dimensional clusters of cortical cells connected by microtrenches for axon and dendrite guidance.
    [Microsystems & Nanoengineering]

    Abstract

    ALS-Related FUS Mutations Alter Axon Growth in Motoneurons and Affect HUD/ELAVL4 and FMRP Activity

    Using both human induced pluripotent stem cells and mouse models, researchers found that FUS-ALS causative mutations affected the activity of two relevant RNA-binding protein with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP.
    [Communications Biology]

    Abstract

    N-Acetylcysteine Prevents Amyloid-β Secretion in Neurons Derived from Human Pluripotent Stem Cells with Trisomy 21

    Researchers established an in vitro cellular model using neurons differentiated from Down syndrome patient-derived induced pluripotent stem cells (iPSCs) and isogenic euploid iPSCs.
    [Scientific Reports]

    Full Article

    Differences in Synaptic Vesicle Pool Behavior between Male and Female Hippocampal Cultured Neurons

    Investigators studied functional parameters of synaptic vesicle recycling in hippocampal cultures from male and female rats, which were a standard model system for many laboratories.
    [Scientific Reports]

    Full Article

    ApoE4 Attenuates Autophagy via FoxO3a Repression in the Brain

    Scientists investigated the effect of Apolipoprotein E (ApoE4) on autophagy in the human brains of ApoE4 carriers.
    [Scientific Reports]

    Full Article

    Explore neural organoid technologies with this free wallchart from STEMCELL and Nature Neuroscience
    REVIEWS

    Microglia Regulation of Synaptic Plasticity and Learning and Memory

    The authors provide an overview of microglia regulation of synaptic plasticity and learning and memory, and discuss the possibility of microglia manipulation as a therapeutic to ameliorate cognitive deficits associated with aging, neurocognitive disorder, and mental disorders.
    [Neural Regeneration Research]

    Full Article

    INDUSTRY AND POLICY NEWS

    GNT Pharma Announces Approval of IND Application for the Phase III RODIN Trial of Nelonemdaz for Acute Ischemic Stroke Patients

    GNT Pharma Inc. reported that the Korea Ministry of Food and Drug Safety has approved the Investigational New Drug Application for a phase III study of nelonemdaz for acute ischemic stroke patients.
    [GNT Pharma Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

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    October 25 – 26, 2021
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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Neuroscience

    Emory University – Atlanta, Georgia, United States

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    University of Maryland, College Park – College Park, Maryland, United States

    Associate Director – Data Science, Neurology

    Eisai Inc. – Woodcliff Lake, New Jersey, United States

    Postdoctoral Research Associate – In Vitro Electrophysiology

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Research Fellow – Neurology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

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