Neural Cell News Volume 15.36 | Sep 15 2021

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    2021-09-15 | NCN 15.36


    Neural Cell News by STEMCELL Technologies
    Vol. 15.36 – 15 September, 2021
    TOP STORY

    RhoA Drives Actin Compaction to Restrict Axon Regeneration and Astrocyte Reactivity after CNS Injury

    An inhibitory extracellular milieu and neuron-intrinsic processes prevented axons from regenerating in the adult central nervous system. Scientists showed how the two aspects were interwoven.
    [Neuron]

    Full ArticleGraphical Abstract

    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    Microglia Modulation with 1070-nm Light Attenuates Aβ Burden and Cognitive Impairment in Alzheimer’s Disease Mouse Model

    Researchers demonstrated that cognitive and memory impairment in an Alzheimer’s disease (AD) mouse model could be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden, the hallmark of AD. The glial cells, including microglia and astrocytes, played important roles in Aβ clearance.
    [Light-Science & Applications]

    Full Article

    Selective Targeting of the TLR2/MyD88/NF-κB Pathway Reduces α-Synuclein Spreading In Vitro and In Vivo

    Scientists showed that preformed α-syn fibrils increased the association between TLR2 and MyD88, resulting in microglial activation.
    [Nature Communications]

    Full Article

    Cilium Induction Triggers Differentiation of Glioma Stem Cells

    The authors showed that patient-derived glioma stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    AIM/CD5L Attenuates DAMPs in the Injured Brain and Thereby Ameliorates Ischemic Stroke

    Investigators reported that AIM protein reduced sterile inflammation by attenuating damage-associated molecular patterns and that AIM administration ameliorated the deleterious effects of ischemic stroke.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Protein Disulphide Isomerase (PDI) Is Protective against Amyotrophic Lateral Sclerosis (ALS)-Related Mutant Fused in Sarcoma (FUS) in In Vitro Models

    Scientists demonstrated that PDI was protective against mutant FUS. In neuronal cell line and primary cultures, PDI restored defects in nuclear import, prevented the formation of mutant FUS inclusions, inhibited Golgi fragmentation, ER stress, ER-Golgi transport defects, and apoptosis.
    [Scientific Reports]

    Full Article

    A Microfluidic Approach to Rescue ALS Motor Neuron Degeneration Using Rapamycin

    Researchers presented a transgenic, TDP-43-A315T, mouse model expressing an amyotrophic lateral sclerosis phenotype and demonstrate the presence of ubiquitinated cytoplasmic TDP-43 aggregates with > 80% cell death by 28 days post differentiation in vitro.
    [Scientific Reports]

    Full Article

    Fenofibrate Inhibits Hypoxia-Inducible Factor-1 Alpha and Carbonic Anhydrase Expression through Activation of AMP-Activated Protein Kinase/HO-1/Sirt1 Pathway in Glioblastoma Cells

    The authors studied the regulatory effects of the PPARα agonist fibrate on the regulation of HIF-1α expression and its downstream target protein in glioblastoma.
    [Environmental Toxicology]

    Abstract

    circFLNA Promotes Glioblastoma Proliferation and Invasion by Negatively Regulating miR-199-3p Expression

    Researchers identified differentially expressed circular RNAs in glioblastoma. Reverse transcription ‑quantitative PCR was used to analyze the expression levels of circFLNA.
    [Molecular Medicine Reports]

    Abstract

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    REVIEWS

    Schwann Cell-Derived Exosomes: Janus-Faced Mediators of Regeneration and Disease

    The authors explore in-depth the exosome-mediated molecular mechanisms involved in the regulation of Schwann cells and their microenvironment.
    [Glia]

    Full Article

    INDUSTRY AND POLICY NEWS

    Researchers Awarded $31 Million for Clinical Trials to Treat Stroke, Heart Failure, Brain Cancer

    The California Institute for Regenerative Medicine has awarded $31 million to three Stanford researchers to launch trials of treatments for common diseases. Four other Stanford researchers also received a total of $4.55 million.
    [Stanford Medicine]

    Press Release

    Aptorum Group Limited Has Received IND Clearance from the US FDA to Initiate Clinical Trials for Repurposed Small Molecule Drug SACT-1 for the Treatment of Neuroblastoma

    Aptorum Group Limited announced that the group has received clearance from the US FDA regarding the IND application to initiate clinical trials of SACT-1, an orally administered repurposed small molecule drug for the treatment of neuroblastoma.
    [Aptorum Group Limited]

    Press Release

    FEATURED EVENT

    14th Annual Meeting of Chinese Neuroscience Society

    September 16 – 19, 2021
    Chongqing, China

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Neuroepithelial Circuits

    Philipps University of Marburg – Marburg, Germany

    Postdoctoral Fellow – Neuroscience

    Emory University – Atlanta, Georgia, United States

    Assistant Professor – Behavioral and Cognitive Neuroscience

    University of Maryland, College Park – College Park, Maryland, United States

    Associate Director – Data Science, Neurology

    Eisai Inc. – Woodcliff Lake, New Jersey, United States

    Postdoctoral Research Associate – In Vitro Electrophysiology

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    > See All Jobs

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