| Vol. 15.37 – 22 September, 2021 |
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| Researchers found that microglia exposed to α-synuclein established a cellular network through the formation of F-actin-dependent intercellular connections, which transferred α-syn from overloaded microglia to neighboring naive microglia where the α-syn cargo got rapidly and effectively degraded. [Cell] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified SON as a master regulator that activated PTBP1-mediated oncogenic splicing while suppressing RBFOX2-mediated non-oncogenic neuronal splicing in glioblastoma multiforme. [Nature Communications] |
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| Using multi-omics data, investigators demonstrated the existence of two retinoblastoma subtypes. They expressed markers of less differentiated cone together with neuronal/ganglion cell markers with marked inter- and intra-tumor heterogeneity. [Nature Communications] |
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| Researchers showed that the transcription factor BCL11A was expressed in a subset of midbrain dopaminergic (mDA) neurons in the developing and adult murine brain and in a subpopulation of pluripotent-stem-cell-derived human mDA neurons. [Cell Reports] |
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| Scientists determined that Pep63, a small peptide, had a neuroprotective effect on synaptic plasticity and memory. They developed novel and multifunctional liposomes targeting both Aβ oligomers and fibrils based on a liposome delivery system. [Cell Death Discovery] |
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| The authors investigated the role of microglial chromodomain-helicase DNA-binding protein 8 and tuberous sclerosis complex 2 in cytokine expression, phagocytosis activity, and neuro/gliogenesis from neural stem cells in vitro. [Scientific Reports] |
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| In search of novel putative therapeutic RNA targets researchers investigated the role of the oncogenic long noncoding RNA LINC00152 in A172 glioblastoma cells. [Scientific Reports] |
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| As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness. [International Journal of Oncology] |
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| Scientists investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2) upon their overexpression on primary human adult cortical astrocytes. [International Journal of Developmental Biology] |
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| Researchers discuss how developmental pruning programs may go awry in neurodevelopmental disorders of the human CNS, focusing on autism spectrum disorder and schizophrenia. [Nature Reviews Neuroscience] |
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| The authors discuss the status of β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE) inhibitors and suggest ways in which the results of the discontinued trials can inform the development of future clinical trials of BACE inhibitors and related secretase modulators as preventative therapies. [Nature Reviews Neurology] |
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| PathMaker Neurosystems, Inc. announced that it was awarded a Phase I STTR grant from NIH’s National Institute of Neurological Disorders and Stroke. The $371,000 award will enable the completion of key pre-clinical studies evaluating the effect of treatment with PathMaker’s technology for motor neuron hyperexcitability suppression in transgenic ALS mice. [PathMaker Neurosystems, Inc.] |
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| October 14, 2021 Wädenswil, Switzerland |
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| University of Southern California – Los Angeles, California, United States |
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| Emory University – Atlanta, Georgia, United States |
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| University of Maryland, College Park – College Park, Maryland, United States |
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| Eisai Inc. – Woodcliff Lake, New Jersey, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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