| Vol. 15.39 – 6 October, 2021 |
| |
|
|
| Scientists integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 adult IDH mutant or IDH wild-type gliomas to delineate sources of intratumoral heterogeneity. [Nature Genetics] |
|
|
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators demonstrated heritability of malignant cell states, with key differences in hierarchal and plastic cell state architectures in IDH-mutant glioma versus IDH-wild-type glioblastoma, respectively. [Nature Genetics] |
|
|
|
| Researchers developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offered a unique opportunity to study the early steps of viral infection and screening antivirals. [Nature Communications] |
|
|
|
| Scientists combined glial chemogenetics with genetically encoded calcium indicators expressed in enteric neurons and glia to study network-level activity in the intact myenteric plexus of the proximal colon. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway. [Cell Death & Disease] |
|
|
|
| Researchers investigated whether hypoxic postconditioning (HPC) could promote neurogenesis after ischemic stroke, and investigated the role of neuronal stem cell metabolism in HPC-induced neuroprotection. [Experimental Neurology] |
|
|
|
| Scientists demonstrated that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor into active prodomain and mature brain-derived neurotrophic factor for synaptic re-use. [Communications Biology] |
|
|
|
| Renshaw cells (RCs) are one of the most studied spinal interneurons; however, their roles in motor control remain enigmatic in part due to the lack of experimental models to interfere with RC function, specifically in adults. Investigators leveraged the distinct temporal regulation of Calbindin expression in RCs to create genetic models for timed RC manipulation. [Scientific Reports] |
|
|
|
| Scientists identified specific modulators of alpha synuclein gene (SNCA) transcription, generated CRISPR/Cas9 modified SNCA-GFP-luciferase genomic fusion- and control cell lines and screened a library of 1649 bioactive compounds, including the FDA approved drugs. [Scientific Reports] |
|
|
|
|
|
| Investigators discuss the limitations of current blioblastoma treatment options and the rationale behind the need for personalized care. [Neuro-Oncology] |
|
|
|
|
| Sunshine Biopharma, Inc. announced that it has filed a patent application for a potential new treatment for neurodegenerative disorders. Sunshine Biopharma’s patent application contains experimental results showing that certain mRNA molecules provide protective effects against oxidative stress in differentiated neuronal cells, a process that mimics neuronal degeneration. [Sunshine Biopharma Inc.] |
|
|
|
|
| October 4 – 7, 2021 Virtual |
|
|
|
|
|
| Center for Molecular and Behavioral Neuroscience – Newark, New Jersey, United States |
|
|
|
| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
|
|
|
| University of Helsinki – Helsinki, Finland |
|
|
|
| University of Southern California – Los Angeles, California, United States |
|
|
|
| Emory University – Atlanta, Georgia, United States |
|
|
|
|