Neural Cell News Volume 15.39 | Oct 6 2021

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    2021-10-06 | NCN 15.39


    Neural Cell News by STEMCELL Technologies
    Vol. 15.39 – 6 October, 2021
    TOP STORY

    Single-Cell Multimodal Glioma Analyses Identify Epigenetic Regulators of Cellular Plasticity and Environmental Stress Response

    Scientists integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 adult IDH mutant or IDH wild-type gliomas to delineate sources of intratumoral heterogeneity.
    [Nature Genetics]

    Abstract

    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Epigenetic Encoding, Heritability and Plasticity of Glioma Transcriptional Cell States

    Investigators demonstrated heritability of malignant cell states, with key differences in hierarchal and plastic cell state architectures in IDH-mutant glioma versus IDH-wild-type glioblastoma, respectively.
    [Nature Genetics]

    Abstract

    Hamster Organotypic Modeling of SARS-CoV-2 Lung and Brainstem Infection

    Researchers developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offered a unique opportunity to study the early steps of viral infection and screening antivirals.
    [Nature Communications]

    Full Article

    Circuit-Specific Enteric Glia Regulate Intestinal Motor Neurocircuits

    Scientists combined glial chemogenetics with genetically encoded calcium indicators expressed in enteric neurons and glia to study network-level activity in the intact myenteric plexus of the proximal colon.
    [Proceedings of the National Academy of Sciences of the United States of America]

    AbstractPress Release

    Astrocytic YAP Prevents the Demyelination through Promoting Expression of Cholesterol Synthesis Genes in Experimental Autoimmune Encephalomyelitis

    Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway.
    [Cell Death & Disease]

    Full Article

    Hypoxic Postconditioning Promotes Neurogenesis by Modulating the Metabolism of Neural Stem Cells after Cerebral Ischemia

    Researchers investigated whether hypoxic postconditioning (HPC) could promote neurogenesis after ischemic stroke, and investigated the role of neuronal stem cell metabolism in HPC-induced neuroprotection.
    [Experimental Neurology]

    Abstract

    Astrocytic Microdomains from Mouse Cortex Gain Molecular Control over Long-Term Information Storage and Memory Retention

    Scientists demonstrated that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor into active prodomain and mature brain-derived neurotrophic factor for synaptic re-use.
    [Communications Biology]

    Full Article

    Genetic Targeting of Adult Renshaw Cells Using a Calbindin 1 Destabilized Cre Allele for Intersection with Parvalbumin or Engrailed1

    Renshaw cells (RCs) are one of the most studied spinal interneurons; however, their roles in motor control remain enigmatic in part due to the lack of experimental models to interfere with RC function, specifically in adults. Investigators leveraged the distinct temporal regulation of Calbindin expression in RCs to create genetic models for timed RC manipulation.
    [Scientific Reports]

    Full Article

    Activators of Alpha Synuclein Expression Identified by Reporter Cell Line-Based High Throughput Drug Screen

    Scientists identified specific modulators of alpha synuclein gene (SNCA) transcription, generated CRISPR/Cas9 modified SNCA-GFP-luciferase genomic fusion- and control cell lines and screened a library of 1649 bioactive compounds, including the FDA approved drugs.
    [Scientific Reports]

    Full Article


    Learn about Parkinson's Disease therapy with hESCs by watching Dr. Malin Parmar's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Extracellular Vesicles: The Key for Precision Medicine in Glioblastoma

    Investigators discuss the limitations of current blioblastoma treatment options and the rationale behind the need for personalized care.
    [Neuro-Oncology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Sunshine Biopharma Files a Patent Application Covering mRNA Molecules for Treatment of Neurodegenerative Diseases

    Sunshine Biopharma, Inc. announced that it has filed a patent application for a potential new treatment for neurodegenerative disorders. Sunshine Biopharma’s patent application contains experimental results showing that certain mRNA molecules provide protective effects against oxidative stress in differentiated neuronal cells, a process that mimics neuronal degeneration.
    [Sunshine Biopharma Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Axon Structure and Function

    October 4 – 7, 2021
    Virtual

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    JOB OPPORTUNITIES

    Assistant Professor – Molecular and Behavioral Neuroscience

    Center for Molecular and Behavioral Neuroscience – Newark, New Jersey, United States

    Postdoctoral Fellowship – Genetics of Alzheimer’s and Parkinson’s

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Researcher – Brain Stem Cell Researcher

    University of Helsinki – Helsinki, Finland

    Assistant Professor – Neuroscience

    University of Southern California – Los Angeles, California, United States

    Postdoctoral Fellow – Neuroscience

    Emory University – Atlanta, Georgia, United States

    > See All Jobs

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