Neural Cell News Volume 15.40 | Oct 13 2021

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    2021-10-13 | NCN 15.40


    Neural Cell News by STEMCELL Technologies
    Vol. 15.40 – 13 October, 2021
    TOP STORY

    DHHC9-Mediated GLUT1 S-Palmitoylation Promotes Glioblastoma Glycolysis and Tumorigenesis

    Scientists found that GLUT1 was palmitoylated at Cys207, and S-palmitoylation was required for maintaining GLUT1 PM localization. They identified DHHC9 as the palmitoyl transferase responsible for this critical posttranslational modification.
    [Nature Communications]

    Full Article

    Find antibodies targeting cell markers relevant in neural research
    PUBLICATIONSRanked by the impact factor of the journal

    TRIP6 Functions in Brain Ciliogenesis

    TRIP6 carries numerous protein interaction domains and its functions require homodimerization. TRIP6 disruption in vitro, via RNAi or inhibition of its homodimerization, confirmed its function in ciliogenesis.
    [Nature Communications]

    Full Article

    ATP-Citrate Lyase Promotes Axonal Transport across Species

    Researchers showed that Acly expression was reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species.
    [Nature Communications]

    Full Article

    Synapse Development Is Regulated by Microglial THIK-1 K+ Channels

    Microglial ramification, motility, and cytokine release are regulated by tonically active THIK-1 K+ channels on the microglial plasma membrane. Researchers examined whether these channels played a role in phagocytosis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma

    Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
    [Cell Death & Disease]

    Full Article

    m6A Reader IGF2BP2-Stabilized CASC9 Accelerates Glioblastoma Aerobic Glycolysis by Enhancing HK2 mRNA Stability

    MeRIP-Seq revealed the m6A profile in the glioblastoma multiforme (GBM). Moreover, the m6A-related long non-coding RNA CASC9 expression was significantly elevated in the GBM tissue and its ectopic high expression was associated with poor survival, acting as an independent prognostic factor for GBM patients.
    [Cell Death Discovery]

    Full Article

    Downregulation of Phosphoglycerate Mutase 5 Improves Microglial Inflammasome Activation after Traumatic Brain Injury

    Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.
    [Cell Death Discovery]

    Full Article

    Viability Fingerprint of Glioblastoma Cell Lines: Roles of Mitotic, Proliferative, and Epigenetic Targets

    Scientists compared the efficacy of focused modulation of a set of signaling pathways in two glioblastoma cell lines, U-251 MG and T98-G, using a panel of thirteen compounds targeting cell cycle progression, proliferation, epigenetic modifications, and DNA repair mechanism.
    [Scientific Reports]

    Full Article

    Disturbance of Phylogenetic Layer-Specific Adaptation of Human Brain Gene Expression in Alzheimer’s Disease

    Investigators identified Alzheimer’s disease (AD)-associated layer-specific differences involving protein-coding and non-coding sequences, most of those present in the subcortical white matter, thus indicating a critical role for long axons and oligodendrocytes in AD pathomechanism.
    [Scientific Reports]

    Full Article

    Organoids: Experts Talk Standardization at Nature Research Round Table
    REVIEWS

    Development of Prefrontal Cortex

    An understanding of the development and evolution of the prefrontal cortex provide insight into the pathogenesis and treatment of congenital neuropsychiatric diseases as well as idiopathic developmental disorders that cause intellectual disabilities.
    [Neuropsychopharmacology]

    Full Article

    Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead?

    The authors discuss the role of pluripotent stem cell-derived neural precursor cells in rat models of MPTP-induced Parkinson’s disease following intranasal injections.
    [ACS Chemical Neuroscience]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Otsuka and Lundbeck Announce FDA Acceptance of Supplemental New Drug Application; Receive Priority Review for Treatment of Schizophrenia in Adolescents

    Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S reported that the US FDA has accepted a Supplemental New Drug Application for the treatment of schizophrenia in adolescents with Rexulti® and has granted Otsuka and Lundbeck Priority Review.
    [Otsuka Pharmaceutical Co., Ltd. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Annual London Stem Cell Network Symposium

    October 19, 2021
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Developmental Neuroscience

    Flanders Institute for Biotechnology – Leuven, Belgium

    Assistant Professor – Molecular and Behavioral Neuroscience

    Center for Molecular and Behavioral Neuroscience – Newark, New Jersey, United States

    Postdoctoral Fellowship – Genetics of Alzheimer’s and Parkinson’s

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Researcher – Brain Stem Cell Researcher

    University of Helsinki – Helsinki, Finland

    Assistant Professor – Neuroscience

    University of Southern California – Los Angeles, California, United States

    > See All Jobs

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