 | | Vol. 15.43 – 3 November, 2021 |
| |
|
|
| Researchers conducted transmission electron microscopy experiments of an intracranial glioblastoma model and showed that ligand-modified nanoparticles traversed the blood–brain barrier, endocytosed into the lysosomes of glioblastoma cells, and underwent endo-lysosomal escape upon photochemical ionization.
[Advanced Materials] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors identified kenpaullone (KP), which enhanced Kcc2/KCC2 expression and functioned in cultured rodent and human neurons by inhibiting GSK3ß.
[Nature Communications] |
|
|
|
| Single-cell RNA-sequencing and proteomics revealed that LGALS3BP-mediated mechanisms involved the extracellular matrix in neural progenitor cells’ anchoring and migration within the human brain.
[Nature Communications] |
|
|
|
| Investigators used a human induced pluripotent stem cell (iPSC)-derived astrocyte model and investigated the temporal patterns of astroglia differentiation during developmental stages critical for schizophrenia using RNA sequencing.
[Translational Psychiatry] |
|
|
|
| The authors tested the chronic effects of low and high doses of lithium on human hippocampal progenitor cells and used immunocytochemistry to investigate the effects of lithium on cell parameters implicated in neurogenesis.
[Translational Psychiatry] |
|
|
|
| Scientists reported that atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide accelerated the dopaminergic differentiation of human induced pluripotent stem cells (hiPSCs)-derived neural population, useful for both neuroprotection and neurorepair in Parkinson’s disease.
[Cell Death Discovery] |
|
|
|
| Investigators created a 3D model of vascularized spheroid cells using an injection-molded microfluidic chip. Gene expression analysis and immunostaining revealed that the vascular network greatly enhanced spheroid differentiation and reduced apoptosis.
[Biotechnology and Bioengineering] |
|
|
|
| The authors generated cerebral organoids derived from human induced pluripotent stem cells (hiPSCs) possessing the KCNJ11 mutation p.Val59Met (V59M) and from non-pathogenic/normal hiPSCs.
[Scientific Reports] |
|
|
|
| Researchers investigated the possible role of very long chain fatty acid (VLCFA)-lipids in frontotemporal dementia (FTD), which was a leading cause of younger-onset dementia, and identified three VLCFA-lipid species that were significantly increased in FTD brain compared to controls.
[Scientific Reports] |
|
|
|
|
| The authors present a combined neural network for environmental stress responses, providing insights into the central circuit mechanism for the integrative regulation of systemic organs.
[Nature Reviews Neuroscience] |
|
|
|
| Scientists discuss potential mechanisms of myelination at different life stages, explore whether myelin plasticity provides the regenerative potential of the central nervous system white matter, and question whether changes in myelin may underlie neurological disorders.
[Nature Neuroscience] |
|
|
|
|
| COMPASS Pathways, Inc. announced it will be conducting a Phase II clinical trial to assess the safety and tolerability of COMP360 psilocybin therapy in post-traumatic stress disorder.
[COMPASS Pathways, Inc.] |
|
|
|
| uniQure, Inc. announced the positive recommendation by the independent Data Safety Monitoring Board following a review of safety data from the four patient procedures in the higher-dose cohort of the Phase I/II clinical trial of AMT-130 for the treatment of Huntington’s disease.
[uniQure, Inc.] |
|
|
|
|
|
November 10 – 11, 2021
Seoul, Korea & Online |
| |
|
|
|
| | The University of Hong Kong – Hong Kong, China |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | University of Calgary – Calgary, Alberta, Canada |
|
|
|
| | Flanders Institute for Biotechnology – Leuven, Belgium |
|
|
|
| | Center for Molecular and Behavioral Neuroscience – Newark, New Jersey, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
