Neural Cell News Volume 15.44 | Nov 10 2021

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    2021-11-10 | NCN 15.44


    Neural Cell News by STEMCELL Technologies
    Vol. 15.44 – 10 November, 2021
    TOP STORY

    PD-1 Independent of PD-L1 Ligation Promotes Glioblastoma Growth through the NFκB Pathway

    Scientists explored a critical role for programmed cell death 1 (PD-1) in brain tumor–initiating cells and uncovered a nonimmune resistance mechanism of patients with glioblastoma to PD-1– or programmed cell death ligand 1 (PD-L1)–blocking therapies.
    [Science Advances]

    Full Article
    Webinar: Organoids as Models for Human Disease
    PUBLICATIONSRanked by the impact factor of the journal

    The Chemotherapeutic CX-5461 Primarily Targets TOP2B and Exhibits Selective Activity in High-Risk Neuroblastoma

    The authors used a comprehensive panel of in vitro and in vivo assays to demonstrate that CX-5461 had been mischaracterized and that its primary target at pharmacologically relevant concentrations was topoisomerase II beta (TOP2B).
    [Nature Communications]

    Full Article

    Competitive Binding of E3 Ligases TRIM26 and WWP2 Controls SOX2 in Glioblastoma

    Investigators identified E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for glioblastoma stem cells identity and maintenance.
    [Nature Communications]

    Full Article

    CD73-Positive Extracellular Vesicles Promote Glioblastoma Immunosuppression by Inhibiting T Cell Clonal Expansion

    The authors detected a higher concentration of CD73+ tumor-derived extracellular vesicles enriched in exosomes in central and peripheral body fluids of glioblastoma patients than in those of patients with other brain tumors.
    [Cell Death & Disease]

    Full Article

    Genetic Inhibition of RIPK3 Ameliorates Functional Outcome in Controlled Cortical Impact Independent of Necroptosis

    Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.
    [Cell Death & Disease]

    Full Article

    Loss of p53 Suppresses Replication Stress-Induced DNA Damage in ATRX-Deficient Neuroblastoma

    Investigators suggested that alpha thalassemia mental retardation X-linked (ATRX) maintained genome integrity and p53 deficiency attenuated replication stress-induced DNA damage in neuroblastoma cells featuring inactivated ATRX by regulating DNA repair mechanisms.
    [Oncogenesis]

    Full Article

    proBDNF Expression Induces Apoptosis and Inhibits Synaptic Regeneration by Regulating the RhoA-JNK Pathway in an In Vitro Post-Stroke Depression Model

    A post-stroke depression (PSD)-like model was established by treating neuronal cells with oxygen-glucose deprivation and corticosterone. Scientists found that protein pro-brain-derived neurotrophic factor (BDNF) levels were higher in the cortex and hippocampus in the PSD group than in the controls.
    [Translational Psychiatry]

    Full Article

    Gene-Corrected p.A30P SNCA Patient-Derived Isogenic Neurons Rescue Neuronal Branching and Function

    Using two clonal gene-corrected isogenic cell lines, investigators identified image-based phenotypes showing impaired neuritic processes. The pathological neurons displayed impaired neuronal activity, reduced mitochondrial respiration, and transcriptional alterations in lipid metabolism.
    [Scientific Reports]

    Full Article

    A Functional Variant of SHARPIN Confers Increased Risk of Late-Onset Alzheimer’s Disease

    SHARPIN showed aberrant cellular localization and reduced the activation of NF-κB, a central mediator of inflammatory and immune responses. Further investigation of the physiologic role of SHARPIN may reveal the mechanism of onset of late-onset Alzheimer’s disease.
    [Journal of Human Genetics]

    Full Article
    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Dissecting the Complexities of Alzheimer Disease with In Vitro Models of the Human Brain

    The authors discuss ongoing efforts to leverage genomic data from patients using cellular reprogramming technologies to recapitulate complex brain systems and build in vitro discovery platforms.
    [Nature Reviews Neurology]

    Abstract

    Caught in Vicious Circles: A Perspective on Dynamic Feed-Forward Loops Driving Oxidative Stress in Schizophrenia

    Scientists review the existing experimental and translational research pinpointing the complex dynamics of oxidative stress mechanisms and their modulation in relation to schizophrenia pathophysiology.
    [Molecular Psychiatry]

    Full Article

    Biomaterials Patterning Regulates Neural Stem Cells Fate and Behavior: The Interface of Biology and Material Science

    Investigators discuss how the physical and biochemical properties of biomaterials, such as their stiffness and elasticity, could influence the behavior of neural stem cells.
    [Journal of Biomedical Materials Research Part A]

    Abstract
    INDUSTRY AND POLICY NEWS

    PureTech Founded Entity Karuna Therapeutics and Zai Lab Announce Strategic Collaboration for Development, Manufacturing, and Commercialization of KarXT in Greater China

    PureTech Health plc and its founded entity, Karuna Therapeutics, Inc. and Zai Lab Limited announced their entry into an exclusive license agreement for the development, manufacturing, and commercialization of KarXT in Greater China, including mainland China, Hong Kong, Macau, and Taiwan.
    [PureTech Health plc]

    Press Release

    Yumanity Therapeutics Announces Positive Top-Line Results of Phase Ib Clinical Trial for YTX-7739 in Patients with Parkinson’s Disease; Company Plans to Advance Program to Phase II

    Yumanity Therapeutics reported that its lead product candidate, YTX-7739, in development for the treatment of Parkinson’s disease, achieved its primary endpoints in a randomized, placebo-controlled Phase Ib clinical trial in patients with mild-to-moderate Parkinson’s disease.
    [Yumanity Therapeutics]

    Press Release
    FEATURED EVENT

    Cell Bio Virtual 2021

    December 1 – 10, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Molecular Mechanisms of ALS

    SickKids Research Institute – Toronto, Ontario, Canada

    Postdoctoral Fellow – Educational Neuroscience

    The University of Hong Kong – Hong Kong, China

    Postdoctoral Fellow – Neural Circuit Formation

    Baylor College of Medicine – Houston, Texas, United States

    Tenure Track Faculty Position – Neuroscience of Movement Disorders

    University of Calgary – Calgary, Alberta, Canada

    Postdoctoral Position – Developmental Neuroscience

    Flanders Institute for Biotechnology – Leuven, Belgium

    > See All Jobs

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