 | | Vol. 15.46 – 24 November, 2021 |
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| Using transplantation of wild-type (WT) neurons, researchers showed that amyloid beta (Aβ) entered WT grafts, and that this was accompanied by microglia infiltration.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Although the classic symptoms of Huntington’s disease manifest in adulthood, neural progenitor cell behavior is already abnormal by 13 weeks’ gestation. To determine how these developmental defects evolve, investigators turned to cell and mouse models.
[Neuron] |
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| To investigate neurogenic potential and cellular diversity, scientists profiled single-nucleus transcriptomes in five hippocampal-entorhinal subregions in humans, macaques, and pigs.
[Neuron] |
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| The authors observed increased expression of HACE1 in gliomas related to control subjects, and found a strong correlation of high HACE1 expression with poor prognosis in patients with WHO grade III and IV as well as low-grade glioma patients receiving radiotherapy.
[Signal Transduction and Targeted Therapy] |
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| Investigators reported the development of a complete labeling and imaging pipeline using genetic code expansion and non-canonical amino acids in neurons that allowed them to fluorescently label masked epitopes in target transmembrane proteins in live neurons, both in dissociated culture and organotypic brain slices.
[Nature Communications] |
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| In cell transplantation therapy for spinal cord injury, grafted human induced pluripotent stem cell (hiPSC)-derived neural stem cell/progenitor cells differentiated into neurons. Scientists found that chemogenetic stimulation of hiPSC-derived neural cells enhanced cell activity and neuron-to-neuron interactions in vitro.
[Cell Reports] |
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| The authors provided proof of principle that allele-specific lowering of polyQ-expanded ataxin-3 by selective antisense oligonucleotides was feasible and long lasting with sparing of wildtype ataxin-3 expression in a human cell culture model that was genetically identical to spinocerebellar ataxia type 3 (SCA3) patients.
[Molecular Therapy-Nucleic Acids] |
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| Investigators reported that irradiation with a single-frequency Terahertz laser on mice cortical neuron cultures increased excitatory synaptic transmission and neuronal firing activities.
[iScience] |
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| Researchers analyzed neuroblastoma cell lines and morphologic subclones representing the adrenergic (ADRN) and mesenchymal (MES) differentiation states and uncovered sharp differences in their telomere protein and telomerase activity levels.
[Communications Biology] |
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| Scientists analyzed the physiological role of Wdr45 and pathophysiological significance of the gene abnormality during mouse brain development. Morphological and biochemical analyses revealed that Wdr45 was expressed in a developmental stage-dependent manner in mouse brain.
[Scientific Reports] |
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| Investigators demonstrated that phosphatidylcholine-enriched media enhanced neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. They also provided evidence that this phospholipid ameliorated the damage of neurons and modulated neuronal plasticity.
[Scientific Reports] |
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| The authors propose a probabilistic model of Alzheimer disease (AD) in which three variants of AD, autosomal dominant AD, APOE ε4-related sporadic AD and APOE ε4-unrelated sporadic AD, feature decreasing penetrance and decreasing weight of the amyloid pathophysiological cascade.
[Nature Reviews Neuroscience] |
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| Scientists review the methods of dynamic morphometrics, consisting of detailed quantification of structural changes of neurons over time, sampling and analyses, focusing on their applications to studies of activity-driven dendritogenesis in vertebrate systems.
[Trends in Neurosciences] |
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| Investigators discuss the utility of alternate bio-fluids, tumor-guided sequencing, epigenomic and fragmentomic methods that may be leveraged to provide the biological means to unlock a wide range of clinical applications for liquid biopsy in glioma.
[British Journal of Cancer] |
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| Brain Scientific, Inc. announced its partnership with LOK Corporation to develop and manage Brain Scientific’s US and global distribution network. This partnership will scale and accelerate Brain Scientific’s neurological devices.
[Brain Scientific, Inc.] |
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| Artizan Biosciences, Inc. and Biohaven Therapeutics Ltd. announced the companies are initiating a therapeutic discovery and development program in Parkinson’s disease (PD), to exploit recent scientific advances in the understanding of pathogenic roles played by the gut microbiome in PD.
[Artizan Biosciences, Inc.] |
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| December 8 – 9, 2021
Virtual |
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| | Recursion – Salt Lake City, Utah, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | SickKids Research Institute – Toronto, Ontario, Canada |
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| | The University of Hong Kong – Hong Kong, China |
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| | Baylor College of Medicine – Houston, Texas, United States |
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