| Vol. 15.47 – 1 December, 2021 |
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| Shed PrP negatively correlated with prion conversion and was markedly redistributed in murine brain in the presence of prion deposits or amyloid plaques, indicating a sequestrating activity. [Science Advances] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed TDP-43 accumulation in intra-muscular nerves from amyotrophic lateral sclerosis (ALS) patients and in axons of human iPSC-derived motor neurons of ALS patients, as well as in motor neurons and neuromuscular junctions of a TDP-43 mislocalization mouse model. [Nature Communications] |
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| Researchers proved that anlotinib facilitated tumor vessel normalization at least partially through CD4+ T cells, reprogrammed the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME, significantly inhibited tumor growth and effectively prevented systemic immunosuppression. [Clinical Cancer Research] |
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| Scientists performed chromatic immunoprecipitation sequencing ChIP-seq on cerebellum from spinocerebellar ataxia type 7 mice and observed increased H3K9-promoter acetylation in DNA repair genes, resulting in increased expression. [Cell Reports] |
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| Investigators reported a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells. [eLife] |
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| RNA sequencing, qRT-PCR, and Western blot analysis were used to identify the aberrant expression and signaling of miR-148a-3p within cells, mice, and patients with Alzheimer’s disease (AD). Researchers implicated the miR-148a-3p/p35/PTEN pathway as an essential contributor to tau hyperphosphorylation. [Molecular Therapy-Nucleic Acids] |
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| To detect potential effects of different glucose levels on gene expression, the authors analyzed the transcriptome of dermal fibroblasts from idiopathic Parkinson’s disease (PD) patients, LRRK2-associated PD patients, and healthy controls, cultured at two different glucose concentrations. [npj Parkinson’s Disease] |
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| Investigators defined several features of circ-Hdgfrp3 and described interesting alterations occurring in motor neurons carrying amyotrophic lateral sclerosis-associated FUS mutations. [iScience] |
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| Through a combination of chemical proteomics, gel-based separation of modified and unmodified proteins and an activity assay, scientists determined that the modified, lysosomal soluble form of exonuclease PLD3 increased dramatically during neuronal maturation and that AMPylation correlated with its catalytic activity. [iScience] |
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| The authors investigated cellular injury-induced processes in the presence of amyloid β (Aβ) pathology and exposed a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes to Aβ42 protofibrils prior to a mechanically induced scratch injury. [Scientific Reports] |
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| Researchers demonstrated that phosphatidylcholine-enriched media enhanced neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. They also provided evidence that this phospholipid ameliorated the damage of neurons and modulated neuronal plasticity. [Scientific Reports] |
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| The authors evaluate and interpret growing evidence that inhibitory interneurons (INs) play an important role in the neural basis of autism, focusing on recent findings showing reduced density and activity of the parvalbumin class of INs. [Nature Neuroscience] |
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| Chemogenetics is poised to support novel interventions against neuropsychiatric diseases and disorders. To evaluate its translational potential, scientists perform a scoping review of applications of chemogenetics that led to the reversal of molecular and behavioral deficits in studies relevant to neuropsychiatric diseases. [Molecular Therapy] |
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| Investigators summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of spinal cord injury. [NPJ Regenerative Medicine] |
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| Lixte Biotechnology Holdings, Inc. announced that the National Cancer Institute has resumed enrolling patients into their pharmacologic study of the ability of Lixte’s lead compound, LB-100, to enter the brain and penetrate recurrent, malignant brain tumors, in patients where surgical removal of their cancer is indicated. [Lixte Biotechnology Holdings, Inc.] |
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| Aileen Anderson, director of the University of California Irvine’s Sue & Bill Gross Stem Cell Research Center and professor of physical medicine & rehabilitation, has been awarded a 30-month, $5.5 million grant from the California Institute for Regenerative Medicine (CIRM). [UCI News] |
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| January 9 – 12, 2022 Portland, Oregon, United States |
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| Karolinska Institute – Danderyd, Sweden |
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| Recursion – Salt Lake City, Utah, United States |
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| Rutgers University – New Brunswick, New Jersey, United States |
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| SickKids Research Institute – Toronto, Ontario, Canada |
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| The University of Hong Kong – Hong Kong, China |
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