| Vol. 15.48 – 8 December, 2021 |
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| After bilateral brain injections, nanotubes showed preferential retention by tumors compared to normal brain and were taken up by glioblastoma cells through scavenger receptor binding and macropinocytosis. [Science Advances] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Neuroblastoma cells can adopt a lineage committed adrenergic (ADRN) or an immature mesenchymal (MES) state. Investigators found that while ADRN cells resembled normal embryonal neuroblasts, MES cells resembled immature precursor cells which also lacked ALK expression. [Cancer Research] |
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| From a genome-wide functional screen, scientists identified pyruvate kinase M2 as a gamma-secretase activator that was highly expressed in the brains of both patients and murine models with Alzheimer’s disease. [Cell Reports] |
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| Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, the authors revealed the regulatory roles of optineurin (OPTN) on neuroinflammation in the pathogenesis of AD. [Journal of Neuroinflammation] |
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| Researchers investigated Smurf1 expression in various glioblastoma (GB) cell lines and patient tissues and found Smurf1 loss elevated PTEN levels that interrupted the epidermal growth factor receptor pathway activity. [iScience] |
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| Scientists investigated the cytoprotective activity of green rooibos in neuronal cells, including probing antioxidant and enzyme inhibitory properties that could explain observed effects in these cells and also investigated the anxiolytic potential of green rooibos using zebrafish larval models. [Food & Function] |
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| The co-culture of endothelial cells with cAMP response element-binding protein-regulated transcription coactivator-1 (CRTC1)-deficient neurons aggravated the cell vulnerability to hypoxia, also supporting the idea that miRNA-132/212 cluster was regulated by CRTC1 and acted as a crucial role in the mitigation of ischemic damage. [Cell Death Discovery] |
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| LncRNAs play critical roles in the tumorigenesis of glioblastoma (GBM) through regulation of various cancer-related genes and signaling pathways. Researchers focused on the essential role of EMT and identified 78 upregulated EMT-related genes in GBM through differential expression analysis. [Scientific Reports] |
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| Scientists generated UM-002, a novel brain penetrant bromodomain and extraterminal domain (BET) inhibitor that reduced glioblastoma cell proliferation in vitro and in a human cerebral brain organoid model. [Scientific Reports] |
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| The authors highlight reproducible findings and emerging trends in recent schizophrenia-related induced pluripotent stem cell (iPSC) studies and illuminate the relevance of the results in the context of human brain development. [Trends in Neurosciences] |
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| Scientists review current evidence for a vulnerability-stress model in which a relative reduction of dopaminergic projections to the ventral striatum and concomitant sensitization of postsynaptic neurons represent a predisposing (hypodopaminergic) vulnerability. [npj Parkinson’s Disease] |
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| Investigators review recent progress in research on the microbial regulation of central nervous system diseases with a focus on major gut microbial metabolites, such as short-chain fatty acids, tryptophan metabolites, and secondary bile acids. [Experimental & Molecular Medicine] |
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| KetamineOne Capital Limited announced that it is entering into a collaborative partnership with Cognetivity Neurosciences Ltd. to study and develop assessments for depression and post-traumatic stress disorder (PTSD). [KetamineOne Capital Limited] |
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| NOXXON Pharma N.V. announced that the first patient was enrolled in an expansion arm of the GLORIA clinical trial of NOX-A12 in MGMT unmethylated brain cancer. [NOXXON Pharma N.V.] |
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| January 12 – 14, 2022 Shanghai, China |
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| Jülich Research Centre- Jülich, Germany |
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| Karolinska Institute – Danderyd, Sweden |
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| Recursion – Salt Lake City, Utah, United States |
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| Rutgers University – New Brunswick, New Jersey, United States |
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| SickKids Research Institute – Toronto, Ontario, Canada |
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