 | | Vol. 15.49 – 15 December, 2021 |
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| Scientists found that lysine-specific histone demethylase 1 (LSD1) inhibition hampered the induction of the activating transcription factor 4, the master regulator of the integrated stress response.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors indicated that KDM6B promoted an oncogenic CDK4/6-pRB-E2F pathway in neuroblastoma cells via H3K27me3-dependent enhancer-promoter interactions.
[Nature Communications] |
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| Investigators established a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons.
[Nature Communications] |
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| To investigate recurrently dysregulated genes in glioblastoma, scientists interrogated allele-specific expression, the difference in expression between two alleles of a gene, in glioblastoma stem cells derived from 43 patients.
[Cancer Research] |
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| Using 3xTg and APP/PS1 mouse models of Alzheimer’s disease, and in vitro model of amyloid beta42 toxicity in primary neuronal cultures and SH-SY5Y neuroblastoma cells, the authors uncovered a key role for cathepsin L in the induction of nuclear lamina damage.
[Aging Cell] |
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| Investigators revealed that HMGA1 and myosin heavy chain 9 (MYH9) were upregulated in gliomas and their expression correlated with WHO grade, and HMGA1 promoted the acquisition of malignant phenotypes and chemoresistance of glioma cells.
[Cell Death & Disease] |
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| A Bergmann glia population was analyzed in the adult cerebellum of different species and showed conservation of neural stem cell-associated marker expression including Sox1, Sox2 and Sox9, in chick, primate and mouse cerebellum tissue.
[Experimental Neurology] |
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| Researchers suggested a novel role of post-translational modification, in which de-small ubiquitin-like modifier (SUMO)-ylation enzyme isoforms competitively regulated mitochondrial dynamics via Drp1 SUMOylation levels, in a tightly controlled process of neuronal differentiation and corticogenesis.
[iScience] |
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| Using ELISA-based chemical screening with wild and mutant superoxide dismutase (SOD1) proteins, the authors screened a new small molecule, PRG-A01, which could block the misfolding/aggregation of SOD1 or TDP-43. The drug rescued the cell death induced by mutant SOD1 in human neuroblastoma cell line.
[Communications Biology] |
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| Utilizing a recently generated Fip200-4A allele that specifically impaired FIP200’s canonical-autophagy function, investigators found that non-canonical functions of FIP200 were required for regulation of mouse neural progenitor/stem cell maintenance and neurogenesis in vivo.
[Scientific Reports] |
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| Scientists focus on cerebral dopamine neurotrophic factor (CDNF), an unconventional neurotrophic protein. CDNF delivered to the brain parenchyma protects and restores dopamine neurons in animal models of Parkinson’s disease.
[Molecular Psychiatry] |
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| The authors summarize the latest findings on the fundamental roles of glioma-derived exosome non-coding RNAs (ncRNAs) that have been implicated in glioma behaviors, immunological regulation, diagnosis potential, and treatment resistance, as well as the current limitations and perspectives.
[Cell Death & Disease] |
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| Analysis of a dataset verified the prognostic value of PD-L1 and revealed an association between PD-L1 mRNA expression and the status of isocitrate dehydrogenase. Increased PD-L1 expression predicts unfavorable overall survival in glioblastoma.
[Bioengineered] |
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| AgeX Therapeutics, Inc. announced a research collaboration with the University of California, Irvine to explore the therapeutic potential of exosomes and other extracellular vesicles produced by neural stem cells derived from AgeX pluripotent stem cells.
[AgeX Therapeutics, Inc.] |
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| January 16 – 20, 2022
Banff, Alberta, Canada |
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| | The Hong Kong University of Science and Technology – Guangzhou, China |
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| | Karolinska Institute – Danderyd, Sweden |
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| | Recursion – Salt Lake City, Utah, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | SickKids Research Institute – Toronto, Ontario, Canada |
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