 | | Vol. 16.00 – 5 January, 2022 |
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| Scientists showed that Celsr2 was highly expressed in both mouse and human spinal motoneurons. Celsr2 knockout promoted axon regeneration and fasciculation in mouse cultured spinal explants.
[Brain] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that a novel Olig2-binding protein, DEAD-box helicase 20 (Ddx20), was indispensable for the survival of neural progenitor cells and oligodendrocyte progenitor cells.
[Cell Death & Differentiation] |
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| The authors engineered the highly migratory and brain tumor tropic human neural stem cells LM-NSC008 (LM008) to continuously secrete high amounts of functional, stable, full-length antibodies against human epidermal growth factor receptor 2 (HER2) without compromising the stemness of LM008 cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| A functional screen of over 1200 miRNA mimics was conducted in neuroblastoma cell lines to discover miRNAs which sensitized cells to low doses of doxorubicin and vincristine chemotherapy used in the treatment of the disease.
[Molecular Therapy] |
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| Scientists found that decreased function of fat mass and obesity-associated protein (FTO) expression in clinical specimens correlated with higher glioma grades and poorer clinical outcomes. Functionally, FTO inhibited growth and invasion in glioblatoma cells in vitro and in vivo.
[Molecular Therapy-Nucleic Acids] |
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| Using stable cell lines expressing alpha-synuclein, the authors examined the correlation between endogenous alpha-synuclein levels and the seeding propensity by exogenous alpha-synuclein preformed fibrils.
[Molecular Neurobiology] |
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| Investigators collected evidence in both cell models and mouse models and showed the effect of miR-132-3p in enhancing the activation of microglial cells and the loss of microglia cells, which was achieved by mediating GLRX.
[eNeuro] |
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| Scientists isolated extracellular vesicles from medulloblastoma and diffused infiltrative pontine glioma patient-derived cell lines and explored the small ncRNA transcriptome.
[Journal of Neuro-Oncology] |
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| Researchers showed that epidermal growth factor (EGF) negatively regulated presynaptic maturation and synapse formation. In cortical neurons, EGF maintained axon elongation and reduced the sizes of growth cones in culture.
[Neurochemical Research] |
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| Investigators observed high KIF5C expression in neurons during the early developmental stage in mice and the human brain. Kif5c deficiency resulted in disturbed cortical neuronal migration, dendritic, and spine growth.
[Pediatric Research] |
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| The authors highlight the latest findings in genomics, neuroimaging and neurobiology that are informing approaches to drug discovery and repurposing and also explore trial data for pimavanserin, a novel agent that shows promise for the treatment of psychosis in people with dementia.
[Nature Reviews Neurology] |
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| Scientists describe emerging tools and technologies being used to probe large-scale brain activity and new approaches to characterize behavior in the context of such measurements.
[Nature Neuroscience] |
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| Investigators describe how oxidative stress and endolysosomal dysfunction, both of which occur in idiopathic Parkinson’s disease, can activate non-mutated leucine-rich repeat kinase-2 (LRRK2) to a similar degree as pathogenic mutations.
[Trends in Neurosciences] |
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| Longeveron, Inc. announced the initiation of its Phase IIa clinical trial evaluating Lomecel-B as a treatment for Alzheimer’s disease (AD), designed to measure brain anatomy using MRI, and include detailed assessments of the inflammatory and vascular systems thought to contribute to the worsening of AD.
[Longeveron, Inc.] |
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| Zynerba Pharmaceuticals, Inc. provided program updates for Fragile X syndrome (FXS), autism spectrum disorder (ASD), 22q11.2 deletion syndrome (22q) and developmental and epileptic encephalopathies (DEE).
[Zynerba Pharmaceuticals, Inc.] |
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| January 21 -23, 2022
Austin, Texas, United States |
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| | Jülich Research Centre – Genua, Germany |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The Hong Kong University of Science and Technology – Guangzhou, China |
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| | Recursion – Salt Lake City, Utah, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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