 | | Vol. 16.01 – 12 January, 2022 |
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| Scientists identified Dpy-30 histone methyltransferase complex regulatory subunit (DPY30), a regulator of histone H3 lysine 4 trimethylation, as a driver of glioblastoma growth in vivo but not in vitro.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| F3-antibody-sorted glioblastoma cells exhibited stem cell gene expression, enhanced self-renewal in culture, drove tumor initiation and serial transplantation, and reconstituted tumor heterogeneity.
[Developmental Cell] |
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| Scientists established a role of de novo lipogenesis for mouse and human brain development and identified a link between progenitor-cell polarity and lipid metabolism.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that TMEM158 expression in human glioma cells in the tumor core was significantly higher than that in noncancerous cells at the tumor edge using bioinformatics analysis.
[Cancer Gene Therapy] |
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| The authors demonstrated that SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)Thr249 phosphorylation played an essential role in maintaining glioma stem cell (GSC) stemness and tumorigenicity.
[Communications Biology] |
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| Investigators identified a TWIST1-mediated transcriptional program associated with dismal outcome in neuroblastoma and involved in the control of pathways mainly linked to the signaling, migration, adhesion, the organization of the extracellular matrix, and the tumor cells versus tumor stroma crosstalk.
[Communications Biology] |
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| Scientists demonstrated the effects of amyloid precursor protein-derived C-terminal fragments (APP-CTFs)-related pathology using induced neural stem cells (iNSCs) from Alzheimer’s disease patient-derived fibroblasts.
[Cell Death Discovery] |
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| The authors’ results showed that the expression of SERTA domain-containing protein 1 (Sertad1) was upregulated in a mouse middle cerebral artery occlusion and reperfusion model and in HT22 cells after oxygen-glucose deprivation/reoxygenation.
[Molecules and Cells] |
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| Investigators showed that the glial fibrillary acidic protein δ (GFAPδ) and GFAPα isoforms differentially regulated the tumor dynamics of glioma cells. Depletion of either isoform increased the migratory capacity of glioma cells.
[Scientific Reports] |
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| Researchers found a relationship between the proteins coded by the most relevant genes associated with ALS and intracellular Ca2+ accumulation.
[Scientific Reports] |
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| Scientists propose that CGG repeat expansion diseases may represent manifestations of a single underlying neuromyodegenerative syndrome in which different organs are affected to different extents depending on the gene location of the repeat expansion.
[Nature Reviews Neurology] |
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| The authors describe approaches, especially neuromodulation procedures, and emerging challenges to address Parkinson’s disease gait issues beyond subthalamic nucleus and the globus pallidus internus stimulation.
[npj Parkinson’s Disease] |
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| Vaxxinity, Inc. announced that the first patient with Parkinson’s disease has been dosed with UB-312 in Part B of a double-blinded, placebo-controlled Phase I clinical trial, following completion of Part A of the Phase I trial in healthy volunteers.
[Vaxxinity, Inc.] |
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| PharmaTher Holdings Ltd. announced that the US FDA has accepted an investigator-initiated IND application to proceed with a Phase II clinical trial evaluating ketamine in the treatment of ALS.
[PharmaTher Holdings Ltd.] |
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| February 10 – 12, 2022
Lorne, Victoria, Australia |
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| | Queen Mary University of London – London, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The Hong Kong University of Science and Technology – Guangzhou, China |
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| | Recursion – Salt Lake City, Utah, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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