 | | Vol. 16.02 – 19 January, 2022 |
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| Investigators used brain organoids to show that although sex chromosomal complement had no observable effect on neurogenesis, sex steroids — namely androgens — led to increased proliferation of cortical progenitors and an increased neurogenic pool.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived glioblastoma (GBM) stem cells (GSCs), differentiated GBM cells, and neural stem cells to identify master regulators of GSC stemness.
[Cancer Discovery] |
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| The authors revealed that reactive transformation could occur cell autonomously in human ALS astrocytes and with a striking degree of early molecular and functional heterogeneity when comparing different disease-causing mutations.
[Brain] |
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| Scientists showed that the neuronal retromer could regulate Alzheimer’s disease (AD)-associated pathologies in two of AD’s principal cell types, which strengthened the link, and clarified the mechanism, between endosomal trafficking and late-onset sporadic AD.
[Cell Reports] |
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| Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.
[NPJ Regenerative Medicine] |
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| The authors revealed crucial roles and a novel mechanism of poly ε-B subunit (POLE2) involved in glioblastoma (GBM) through aurora kinase A (AURKA)-mediated stability of forkhead transcription factor (FOXM1) and may provide the theoretical basis of molecular therapy for GBM.
[Cell Death & Disease] |
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| Scientists found that NEK2 knockdown attenuated cell proliferation, migration, invasion, and tumorigenesis of glioblastoma (GBM) while NEK2 overexpression promoted the GBM progression.
[Cell Death & Disease] |
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| Researchers investigated Parkinson’s disease (PD)’s mechanism using dopaminergic neurons differentiated from human induced pluripotent stem cells (iPSCs) carrying the ILE368ASN mutation within the PINK1 gene, which was strongly associated with PD.
[Communications Biology] |
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| CircRNA cyclin B1 (circCCNB1) knockdown reduced cyclin D1 (CCND1) expression in glioma cells and CCND1 overexpression bated the effect of circCCNB1 knockdown on glioma cell growth.
[Metabolic Brain Disease] |
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| Investigators showed that CCL18 did not change the expression of the inflammatory factors, interleukin (IL)-1β, IL-6, tumor necrosis factor alpha, or inducible nitric oxide synthase, but significantly induced expression of the macrophage markers, MRC-1 and ARG-1 M2, in a human microglial clone 3 cell line.
[Journal of Interferon and Cytokine Research] |
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| The authors provide a futher understanding of the therapeutic role of neural stem cells for ischemic stroke, and evaluate their prospects for future application in clinical patients of ischemic stroke.
[Translational Stroke Research] |
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| Scientists discuss multiple pathophysiological aspects of white matter injury along with glial dynamics, and the pharmacotherapies including recent insights into the application of mesenchymal stem cells as a therapeutic modality in treating white matter injury.
[Molecular Neurobiology] |
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| Orbus Therapeutics, Inc. announced that patient enrollment of its Phase III STELLAR clinical study of eflornithine in patients with recurrent anaplastic astrocytoma is complete. The STELLAR study completed full enrollment with a total of 343 patients.
[Orbus Therapeutics, Inc.] |
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| AI Therapeutics, Inc., a clinical-stage biopharmaceutical company developing novel therapeutics for rare diseases, announced the initiation of a Phase II study for a promising new approach to treat ALS.
[AI Therapeutics, Inc.] |
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| | Free University of Berlin – Berlin, Germany |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The Hong Kong University of Science and Technology – Guangzhou, China |
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| | Recursion – Salt Lake City, Utah, United States |
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