| Vol. 16.04 – 2 February, 2022 |
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| Scientists used organoid models of the human cerebral cortex to identify cell-type-specific developmental abnormalities that resulted from haploinsufficiency in three autism spectrum disorder risk genes — SUV420H1, ARID1B and CHD8 — in multiple cell lines from different donors. [Nature] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated a human model for tuberous sclerosis complex (TSC) by growing cerebral organoids from patients who carried mutations in TSC2. [Science] |
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| Scientists found that immune genes exhibited a primed chromatin state in single mouse and human oligodendroglia in a non-disease context, compatible with transitions to immune-competent states in multiple sclerosis. [Neuron] |
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| Aberrant upregulation of the glycolytic enzyme PFKFB3 in neurons may have contributed to CLN7 pathogenesis and targeting PFKFB3 could alleviate this and other lysosomal storage diseases. [Nature Communications] |
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| Using inducible deletion of Sox5 or Sox6 in the adult mouse brain, the authors showed that both genes were required for radial glia-like morphology activation and the generation of new neurons. [Cell Reports] |
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| Researchers identified a natural product patchouli alcohol as a selective estrogen receptor β agonist which improved the cognitive defects in female APP/PS1 mice, and explored the underlying mechanisms. [Acta Pharmacologica Sinica] |
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| Analysis of glioblastoma patient cohorts revealed a significantly higher expression of glycosyltransferase 8 domain containing 1 (GLT8D1) compared to normal brain tissue and could be associated with impaired patient survival. [iScience] |
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| Using human pluripotent stem cell (hPSC)-derived brain organoids (BOs), investigators demonstrated that β-site APP-cleaving enzyme 2 (BACE2) was mainly expressed in the ventricular zone and cortical plate of BOs, and its expression level was gradually increased along with the BO maturation. [Cell Death Discovery] |
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| Using in silico and in vitro techniques, scientists demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma. [Scientific Reports] |
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| Investigators suggested that transcriptomic profiling could provide a novel information source for studying the neuropathogenesis of enterovirus-A71 infection leading to the development of an effective therapeutic measure for central nervous system complications. [Scientific Reports] |
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| The authors portray the clinically relevant trends in glyconeurobiology and suggest glyco-related paths that could be targeted therapeutically to decrease neuroinflammation. [Trends in Molecular Medicine] |
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| In vitro studies have shown that pluripotent cells associated with neural scaffolds elaborated by tissue engineering can increase functional recovery, revascularization, remyelination, neurotrophin expression and reduce muscle atrophy. [Cellular and Molecular Neurobiology] |
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| MAO-B inhibitors are a significant therapeutic option for Parkinson’s disease, an option which is too often not appreciated properly. [Journal of Neural Transmission] |
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| Reviva Pharmaceuticals Holdings, Inc. announced that the first patients have been dosed in a pivotal Phase III study and long-term safety trial to assess Reviva’s new chemical entity brilaroxazine for the treatment of subjects with an acute exacerbation of schizophrenia. [Reviva Pharmaceuticals Holdings, Inc.] |
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| The ISS will include an experiment by five students from the Luxembourg Center of System Biomedicine at Belval, who have been growing so-called “organoids”, mini brains that will be able to grow in micro gravity and thus help advance research in the fight against Parkinson’s disease. [RTL Luxembourg] |
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| March 9 – 11, 2022 Melbourne, Victoria, Australia |
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| NC State University – Raleigh, North Carolina, United States |
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| Merck Sharp and Dohme Limited – London, United Kingdom |
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| Hector Institute for Translational Brain Research – Mannheim, Germany |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Free University of Berlin – Berlin, Germany |
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