Neural Cell News Volume 16.04 | Feb 2 2022

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    2022-02-02 | NCN 16.04


    Neural Cell News by STEMCELL Technologies
    Vol. 16.04 – 2 February, 2022
    TOP STORY

    Autism Genes Converge on Asynchronous Development of Shared Neuron Classes

    Scientists used organoid models of the human cerebral cortex to identify cell-type-specific developmental abnormalities that resulted from haploinsufficiency in three autism spectrum disorder risk genes — SUV420H1, ARID1B and CHD8 — in multiple cell lines from different donors.
    [Nature]

    AbstractPress Release
    Find antibodies targeting cell markers relevant in neural research
    PUBLICATIONSRanked by the impact factor of the journal

    Amplification of Human Interneuron Progenitors Promotes Brain Tumors and Neurological Defects

    Investigators generated a human model for tuberous sclerosis complex (TSC) by growing cerebral organoids from patients who carried mutations in TSC2.
    [Science]

    AbstractPress ReleaseGraphical Abstract

    Epigenomic Priming of Immune Genes Implicates Oligodendroglia in Multiple Sclerosis Susceptibility

    Scientists found that immune genes exhibited a primed chromatin state in single mouse and human oligodendroglia in a non-disease context, compatible with transitions to immune-competent states in multiple sclerosis.
    [Neuron]

    Full ArticleGraphical Abstract

    Aberrant Upregulation of the Glycolytic Enzyme PFKFB3 in CLN7 Neuronal Ceroid Lipofuscinosis

    Aberrant upregulation of the glycolytic enzyme PFKFB3 in neurons may have contributed to CLN7 pathogenesis and targeting PFKFB3 could alleviate this and other lysosomal storage diseases.
    [Nature Communications]

    Full Article

    SoxD Genes Are Required for Adult Neural Stem Cell Activation

    Using inducible deletion of Sox5 or Sox6 in the adult mouse brain, the authors showed that both genes were required for radial glia-like morphology activation and the generation of new neurons.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Patchouli Alcohol as a Selective Estrogen Receptor β Agonist Ameliorates AD-Like Pathology of APP/PS1 Model Mice

    Researchers identified a natural product patchouli alcohol as a selective estrogen receptor β agonist which improved the cognitive defects in female APP/PS1 mice, and explored the underlying mechanisms.
    [Acta Pharmacologica Sinica]

    Abstract

    Enzymatic Activity of Glycosyltransferase GLT8D1 Promotes Human Glioblastoma Cell Migration

    Analysis of glioblastoma patient cohorts revealed a significantly higher expression of glycosyltransferase 8 domain containing 1 (GLT8D1) compared to normal brain tissue and could be associated with impaired patient survival.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    BACE2 Variant Identified from HSCR Patient Causes AD-Like Phenotypes in hPSC-Derived Brain Organoids

    Using human pluripotent stem cell (hPSC)-derived brain organoids (BOs), investigators demonstrated that β-site APP-cleaving enzyme 2 (BACE2) was mainly expressed in the ventricular zone and cortical plate of BOs, and its expression level was gradually increased along with the BO maturation.
    [Cell Death Discovery]

    Full Article

    CD97 Is Associated with Mitogenic Pathway Activation, Metabolic Reprogramming, and Immune Microenvironment Changes in Glioblastoma

    Using in silico and in vitro techniques, scientists demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma.
    [Scientific Reports]

    Full Article

    Transcriptome of Human Neuroblastoma SH-SY5Y Cells in Response to 2B Protein of Enterovirus-A71

    Investigators suggested that transcriptomic profiling could provide a novel information source for studying the neuropathogenesis of enterovirus-A71 infection leading to the development of an effective therapeutic measure for central nervous system complications.
    [Scientific Reports]

    Full Article
    ON987CXN-feb-728x90-2022
    REVIEWS

    Role and Therapeutic Implications of Protein Glycosylation in Neuroinflammation

    The authors portray the clinically relevant trends in glyconeurobiology and suggest glyco-related paths that could be targeted therapeutically to decrease neuroinflammation.
    [Trends in Molecular Medicine]

    Full Article

    Stem Cells and Tissue Engineering-Based Therapeutic Interventions: Promising Strategies to Improve Peripheral Nerve Regeneration

    In vitro studies have shown that pluripotent cells associated with neural scaffolds elaborated by tissue engineering can increase functional recovery, revascularization, remyelination, neurotrophin expression and reduce muscle atrophy.
    [Cellular and Molecular Neurobiology]

    AbstractGraphical Abstract

    A Critical Appraisal of MAO-B Inhibitors in the Treatment of Parkinson’s Disease

    MAO-B inhibitors are a significant therapeutic option for Parkinson’s disease, an option which is too often not appreciated properly.
    [Journal of Neural Transmission]

    Full Article
    INDUSTRY AND POLICY NEWS

    Reviva Pharmaceuticals Announces First Patients Dosed in Pivotal Phase III Study and Long-Term Safety Trial Evaluating Brilaroxazine for the Treatment of Schizophrenia

    Reviva Pharmaceuticals Holdings, Inc. announced that the first patients have been dosed in a pivotal Phase III study and long-term safety trial to assess Reviva’s new chemical entity brilaroxazine for the treatment of subjects with an acute exacerbation of schizophrenia.
    [Reviva Pharmaceuticals Holdings, Inc.]

    Press Release

    Luxembourg Students to Send “Mini Brains” to the ISS

    The ISS will include an experiment by five students from the Luxembourg Center of System Biomedicine at Belval, who have been growing so-called “organoids”, mini brains that will be able to grow in micro gravity and thus help advance research in the fight against Parkinson’s disease.
    [RTL Luxembourg]

    Press Release
    FEATURED EVENT

    The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

    March 9 – 11, 2022
    Melbourne, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Neural Stem Cells

    NC State University – Raleigh, North Carolina, United States

    Postdoctoral Research Fellow – Neurodegeneration

    Merck Sharp and Dohme Limited – London, United Kingdom

    PhD Position – Neurobiology

    Hector Institute for Translational Brain Research – Mannheim, Germany

    Senior Researcher – Neurobiology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    PhD Position – Neurophysiology

    Free University of Berlin – Berlin, Germany

    > See All Jobs

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