 | | Vol. 16.05 – 9 February, 2022 |
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| Using knockout mouse models, researchers confirmed that selenoprotein P and its receptor low-density lipoprotein receptor-related protein 8 were required for the exercise-induced increase in adult hippocampal neurogenesis.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that ten–eleven translocation (TET) 2 loss associated with glioblastoma (GBM) stem cells and correlated with poor survival of GBM patients.
[Signal Transduction and Targeted Therapy] |
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| EPHA2 might contribute to platelet-derived growth subunit A (PDGFA) signaling transduction in combination with platelet-derived growth receptor α (PDGFRA) and mediate the resistance of glioblastoma cells to PDGFRA inhibitor.
[Signal Transduction and Targeted Therapy] |
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| The authors interrogated the role of Adenosine-to-Inosine RNA editing mediated by adenosine deaminase acting on RNA (ADAR) in glioblastoma stem cells (GSCs) and found that both ADAR1 and global RNA editomes were elevated in GSCs compared to normal neural stem cells.
[Journal of Clinical Investigation] |
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| To model human malformations of cortical development associated with nitrogen permease regulator-like 3 (NPRL3) variants, researchers created a focal Nprl3 KO in fetal mouse cortex by in utero electroporation and found altered cortical lamination and white matter heterotopic neurons
[Brain] |
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| Scientists revealed a previously undefined cell type-specific role of 2-arachidonoylglycerol metabolism and signaling pathways in traumatic brain injury-induced neuropathology.
[Brain] |
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| Investigators showed that LAMP2A expression was enriched in patient-derived glioblastoma stem cells (GSC), and its depletion diminished GSC-mediated tumorigenic activities.
[Cancer Research] |
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| Researchers investigated inflammatory signaling pathways in neuroblastoma, a classically “cold” pediatric cancer. By testing the functional response of a panel of 20 diverse neuroblastoma cell lines to three different inflammatory stimuli, they found that all cell lines have intact interferon signaling.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Rodent models of Lowe syndrome (LS) have been generated but failed to recapitulate features of the human disease. Investigators described the generation of human stem cell lines from LS patients.
[Biology Open] |
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| The authors outline advances in iPSC modeling and therapeutic development for cardinal neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease.
[Cell Stem Cell] |
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| Scientists review how the different autophagic pathways may protect against neurodegeneration, giving examples of both polygenic and monogenic diseases.
[Neuron] |
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| Investigators summarize recent advances in the field and discuss them in the context of both historical and emerging hypotheses for Parkinson’s disease development, with a particular focus on the application of rodent models as systems allowing for mechanistic hypothesis testing.
[Trends in Microbiology] |
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| Alzheon, Inc. reported a clinically relevant and statistically significant plasma biomarker reduction and memory improvement in Alzheimer’s patients following 6 months of treatment with oral tablet ALZ-801 in its Phase II biomarker trial.
[Alzheon, Inc.] |
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| uniQure N.V. announced the dosing of the first two patients in its European open-label Phase Ib/II clinical trial of AMT-130, a potential one-time gene-therapy approach for the treatment of Huntington’s disease.
[uniQure N.V.] |
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| March 9 – 12, 2022
Munich, Germany |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | NC State University – Raleigh, North Carolina, United States |
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| | Merck Sharp and Dohme Limited – London, United Kingdom |
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| | Hector Institute for Translational Brain Research – Mannheim, Germany |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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