 | | Vol. 16.06 – 16 February, 2022 |
| |
|
|
| Scientists demonstrated that in human neural stem cells, lysosomes were asymmetrically inherited during mitosis.
[Science Advances] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators showed that human enterovirus A71 (HEVA71)-infected astrocytes released CXCL1 which supported viral replication in neurons by activating the CXCR2 receptor-associated ERK1/2 signaling pathway.
[Nature Communications] |
|
|
|
| Researchers showed that stimulation of neurons caused condensation of large chromatin domains. This phenomenon could be observed in vitro in cultured rat hippocampal neurons as well as in vivo in the amygdala and hippocampal neurons.
[Cell Reports] |
|
|
|
| Scientists disclosed an important role for YME1L in coordinating the switch between metabolic states of neural stem and progenitor cells (NSPCs) and suggested that NSPC fate was regulated by compartmentalized changes in protein network dynamics.
[Cell Reports] |
|
|
|
| The authors identified that silencing LINC01296 repressed neuroblastoma cell proliferation and migration, and promoted apoptosis. LINC01296 knockdown inhibited tumor growth in vivo.
[Molecular Therapy Oncolytics] |
|
|
|
| Investigators applied high content imaging on induced pluripotent stem cell-derived neurons from patients with familial Parkinson’s disease bearing the G209A α-synuclein mutation and launched a screening campaign on a small kinase inhibitor library.
[npj Parkinson’s Disease] |
|
|
|
| The authors provided the first evidence for the existence of GalNAc-type O-glycans on TrkA and altered O-glycan structures by core 1 β1,3-galactosyltransferase (C1GALT1) could regulate TrkA signaling in neuroblastoma cells.
[Oncogenesis] |
|
|
|
| Scientists showed that utilizing dual-single guide RNAs (sgRNAs) and a homology-directed repair template with the CRISPR/Cas9 gene-editing system could be a promising avenue for the treatment of glioblastoma multiforme.
[Scientific Reports] |
|
|
|
| Researchers developed an artificial intelligence capable of predicting the seizure liability of drugs and identifying drugs using deep learning based on raster plots of neural network activity.
[Scientific Reports] |
|
|
|
| Investigators found that AGA(C8R)-HNG17 conferred protection against necrosis in neuronal cell lines PC-12 and NSC-34, where necrosis was induced in a glucose-free medium by either chemohypoxia or by a shift from apoptosis to necrosis.
[Biophysical Journal] |
|
|
|
|
| The authors highlight general mechanisms of astrocyte regulation and their potential as therapeutic targets, including drugs that alter astrocyte metabolism, and therapies that target transporters and receptors on astrocytes.
[Nature Reviews Drug Discovery] |
|
|
|
| Scientists review the major epigenetic alterations underlying malignant gliomas, their likely mechanisms of action, and potential strategies for their therapeutic targeting.
[Laboratory Investigation] |
|
|
|
|
| Aquinnah Pharmaceuticals announced that it has signed an agreement with Roche to advance the development of brain penetrant oral small molecules to treat ALS and other neurodegenerative diseases.
[Aquinnah Pharmaceuticals] |
|
|
|
|
| March 15 – 20, 2022
Barcelona, Spain & Online |
|
|
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | Harvard Medical School – Boston, Massachusetts, United States |
|
|
|
| | NC State University – Raleigh, North Carolina, United States |
|
|
|
| | Merck Sharp and Dohme Limited – London, United Kingdom |
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
